A scripted control system for autonomous hardware-timed experiments.

We present the labscript suite, an open-source experiment control system for automating shot-based experiments and their analysis. Experiments are composed as Python code, which is used to produce low-level hardware instructions. They are queued up and executed on the hardware in real time, synchronized by a pseudoclock. Experiment parameters are manipulated graphically, and analysis routines are run as new data are acquired. With this system, we can easily automate exploration of parameter spaces, including closed-loop optimization.

Superflow in a toroidal Bose-Einstein condensate: an atom circuit with a tunable weak link.

We have created a long-lived (≈40 s) persistent current in a toroidal Bose-Einstein condensate held in an all-optical trap. A repulsive optical barrier across one side of the torus creates a tunable weak link in the condensate circuit, which can affect the current around the loop. Superflow stops abruptly at a barrier strength such that the local flow velocity at the barrier exceeds a critical velocity. The measured critical velocity is consistent with dissipation due to the creation of vortex-antivortex pairs. This system is the first realization of an elementary closed-loop atom circuit.

Observation of a 2D Bose gas: from thermal to quasicondensate to superfluid.

We present experimental results on a Bose gas in a quasi-2D geometry near the Berezinskii, Kosterlitz, and Thouless (BKT) transition temperature. By measuring the density profile after time of flight and the coherence length, we identify different states of the gas. We observe that the gas develops a bimodal distribution without long range order. In this regime, the gas presents a longer coherence length than the thermal cloud; it is quasicondensed but is not superfluid. Experimental evidence indicates that we also observe the superfluid transition (BKT transition). For a sufficiently long time of flight, we observe a trimodal distribution when the gas has developed a superfluid component.

Amphiphilic block copolymer nanotubes and vesicles stabilized by photopolymerization.

We report on a new method to stabilize nanotube and vesicle structures created from amphiphilic diblock copolymers by means of photopolymerization. Cross-linking with UV light exposure minimizes fluid disruption during stabilization. Additionally, the spatial control afforded by focusing or masking the initiating light source enables stabilization of distinct segments of individual nanostructures. This contribution demonstrates (1) that vesicles and nanotubes formed from poly(ethylene oxide)-block-polybutadiene are stabilized by exposure to UV light in the presence of a water-soluble photoinitiator and (2) that new nanotube geometries can be constructed by means of spot-curing, and (3) it reveals an application for photopolymerized nanotubes by showing electrophoresis of DNA through a UV-stabilized nanotube.

Observation of persistent flow of a Bose-Einstein condensate in a toroidal trap.

We have observed the persistent flow of Bose-condensed atoms in a toroidal trap. The flow persists without decay for up to 10 s, limited only by experimental factors such as drift and trap lifetime. The quantized rotation was initiated by transferring one unit variant Planck's over 2pi of the orbital angular momentum from Laguerre-Gaussian photons to each atom. Stable flow was only possible when the trap was multiply connected, and was observed with a Bose-Einstein condensate fraction as small as 20%. We also created flow with two units of angular momentum and observed its splitting into two singly charged vortices when the trap geometry was changed from multiply to simply connected.

Quantized rotation of atoms from photons with orbital angular momentum.

We demonstrate the coherent transfer of the orbital angular momentum of a photon to an atom in quantized units of variant Planck's over 2pi, using a 2-photon stimulated Raman process with Laguerre-Gaussian beams to generate an atomic vortex state in a Bose-Einstein condensate of sodium atoms. We show that the process is coherent by creating superpositions of different vortex states, where the relative phase between the states is determined by the relative phases of the optical fields. Furthermore, we create vortices of charge 2 by transferring to each atom the orbital angular momentum of two photons.

High-order quantum resonances observed in a periodically kicked Bose-Einstein condensate.

We have observed high-order quantum resonances in a realization of the quantum delta-kicked rotor, using Bose-condensed Na atoms subjected to a pulsed standing wave of laser light. These resonances occur for pulse intervals that are rational fractions of the Talbot time, and are characterized by ballistic momentum transfer to the atoms. The condensate's narrow momentum distribution not only permits the observation of the quantum resonances at 3/4 and 1/3 of the Talbot time, but also allows us to study scaling laws for the resonance width in quasimomentum and pulse interval.

Photoassociation of sodium in a Bose-Einstein condensate.

We form ultracold Na2 molecules by single-photon photoassociation of a Bose-Einstein condensate, measuring the photoassociation rate, linewidth, and light shift of the J = 1, v = 135 vibrational level of the A1 Sigma (+)(u) molecular state. The photoassociation rate constant increases linearly with intensity, even where it is predicted that many-body effects might limit the rate. Our observations are in good agreement with a two-body theory having no free parameters.

Creating massive entanglement of Bose-Einstein condensed atoms.

We propose a direct, coherent coupling scheme that can create massively entangled states of Bose-Einstein condensed atoms. Our idea is based on an effective interaction between two atoms from coherent Raman processes through a (two atom) molecular intermediate state. We compare our scheme with other recent proposals for the generation of massive entanglement of Bose condensed atoms.

Dynamical tunnelling of ultracold atoms.

The divergence of quantum and classical descriptions of particle motion is clearly apparent in quantum tunnelling between two regions of classically stable motion. An archetype of such non-classical motion is tunnelling through an energy barrier. In the 1980s, a new process, 'dynamical' tunnelling, was predicted, involving no potential energy barrier; however, a constant of the motion (other than energy) still forbids classically the quantum-allowed motion. This process should occur, for example, in periodically driven, nonlinear hamiltonian systems with one degree of freedom. Such systems may be chaotic, consisting of regions in phase space of stable, regular motion embedded in a sea of chaos. Previous studies predicted dynamical tunnelling between these stable regions. Here we observe dynamical tunnelling of ultracold atoms from a Bose-Einstein condensate in an amplitude-modulated optical standing wave. Atoms coherently tunnel back and forth between their initial state of oscillatory motion (corresponding to an island of regular motion) and the state oscillating 180 degrees out of phase with the initial state.

An optical tweezers-based immunosensor for detection of femtomoles-per-liter concentrations of antigens.

We used optical tweezers--optical trapping with focused laser beams--to pull microspheres coated with antigens off of an antibody-coated surface. Using this technique, we could quantify the force required to separate antigen to antibody bonds. At very low surface density of antigen, we were able to detect the single antigen to antibody binding. The force required to break the antigen-antibody bonds and pull the microsphere off the surface was shown to increase monotonically with increasing surface density of antigens. Using the force determination as a transducer, we were able to detect concentrations of free antigens in solution as small as 10(-15) mol/L in a competitive binding assay.

Imaging the phase of an evolving bose-einstein condensate wave function

We demonstrate a spatially resolved autocorrelation measurement with a Bose-Einstein condensate and measure the evolution of the spatial profile of its quantum mechanical phase. Upon release of the condensate from the magnetic trap, its phase develops a form that we measure to be quadratic in the spatial coordinate. Our experiments also reveal the effects of the repulsive interaction between two overlapping condensate wave packets and we measure the small momentum they impart to each other.

Generating solitons by phase engineering of a bose-einstein condensate

Quantum phase engineering is demonstrated with two techniques that allow the spatial phase distribution of a Bose-Einstein condensate (BEC) to be written and read out. A quantum state was designed and produced by optically imprinting a phase pattern onto a BEC of sodium atoms, and matter-wave interferometry with spatially resolved imaging was used to analyze the resultant phase distribution. An appropriate phase imprint created solitons, the first experimental realization of this nonlinear phenomenon in a BEC. The subsequent evolution of these excitations was investigated both experimentally and theoretically.

A well-collimated quasi-continuous atom laser

Extraction of sodium atoms from a trapped Bose-Einstein condensate (BEC) by a coherent, stimulated Raman process is demonstrated. Optical Raman pulses drive transitions between trapped and untrapped magnetic sublevels, giving the output-coupled BEC fraction a well-defined momentum. The pulsed output coupling can be run at such a rate that the extracted atomic wave packets strongly overlap, forming a highly directional, quasi-continuous matter wave.

Optical tweezers-based immunosensor detects femtomolar concentrations of antigens.

We used optical tweezers (optical trapping technology) to measure the force required to separate antigen-antibody bonds. Under competitive-binding conditions, we used the force determination to detect and measure protein antigen concentrations as small as 1 fmol/L (10(-15) mol/L).

Optically controlled collisions of biological objects to evaluate potent polyvalent inhibitors of virus-cell adhesion.

BACKGROUND: The biochemical and biomechanical determinants of adhesion between two biological objects following a collision are complex, and may vary from one system to another. We wished to develop an assay in which all the relevant factors, including the components of the solution, the relative orientation and the relative collision velocity, are under the user's control. RESULTS: A new assay is described in which two mesoscale particles are caused to collide using two independently controlled optical tweezers (optically controlled collision, OPTCOL). This assay enables precise examination of the probability of adhesion under biologically relevant conditions. The OPTCOL assay was used to evaluate the probability of adhesion of a single erythrocyte to a single virus-coated microsphere, in the absence and presence of a sialic acidbearing inhibitor. Inhibition constants for the most effective inhibitors could not be measured using other types of assays. The best inhibitor prevented attachment 50 % of the time at a sialic acid concentration of 35 pmol l-1; it is the most potent known inhibitor of attachment of influenza virus to erythrocytes. CONCLUSIONS: OPTCOL is a versatile new bioassay for studying dynamic interactions in biochemistry. It offers an approach to investigating interactions between moving biological objects that is both quantitative and interpretable. The simplicity of the OPTCOL technique suggests broad applicability to the study of adhesion of mesoscale (1-100 microm) objects in the areas of cell biology, microbiology, medicinal chemistry, and biophysics.