The modulation of the hexosamine biosynthetic pathway impacts the localization of CD36 in macrophages.

CD36 is a type 2 cell surface scavenger receptor expressed in various tissues. In macrophages, CD36 recognizes oxidized low-density lipoprotein (ox-LDL), which promotes the formation of foam cells, the first step toward an atherosclerotic arterial lesion. CD36 possesses a variety of posttranslational modifications, among them N-glycosylation and O-GlcNAc modification. Some of the roles of these modifications on CD36 are known, such as N-linked glycosylation, which provides proper folding and trafficking to the plasma membrane in the human embryonic kidney. This study aimed to determine whether variations in the availability of UDP-GlcNAc could impact Rab-5-mediated endocytic trafficking and, therefore, the cellular localization of CD36. These preliminary results suggest that the availability of the substrate UDP-GlcNAc, modulated in response to treatment with Thiamet G (TMG), OSMI-1 (O-GlcNAcylation enzymes modulators) or Azaserine (HBP modulator), influences the localization of CD36 in J774 macrophages, and the endocytic trafficking as evidenced by the regulatory protein Rab-5, between the plasma membrane and the cytoplasm.

Reported epidemiology of cancer of the lip, oral cavity and oropharynx in Mexico.

En 2008, la Organización Mundial de la Salud reportó que el 13% de las muertes en todo el mundo estuvieron relacionadas con el cáncer. Debido a su magnitud, es un problema prioritario de salud pública del cual se requiere información epidemiológica suficiente para optimizar programas nacionales de salud. El objetivo de esta revisión de la literatura es describir los tipos de cáncer más comunes de labio, cavidad oral y orofaringe reportados en la población mexicana. Se realizó una revisión sistemática siguiendo los lineamientos PRISMA. La información disponible se compiló de las bases de datos electrónicas PubMed, Google Académico y Science Direct, así como de las bases abiertas de datos de salud nacionales. La búsqueda electrónica se realizó con las siguientes palabras clave en inglés "(oral cancer OR oral neoplasm) AND (Mexico) AND (epidemiology OR prevalence)", y sus equivalentes en español.In 2008 the World Health Organization reported that 13% of worldwide deaths were related to cancer. Due to its magnitude, this pathology has become a central public health problem. Therefore epidemiological information at national level is required to optimize health care programs. The aim of this review is to describe the most common types of cancer in lips, oral cavity, and oropharynx reported in Mexican population. A systematic review was carried out following PRISMA guidelines; information was compiled from electronic databases PubMed, Google Scholar and Science Direct, as well as from open Mexican health databases. Electronic search was performed using following Medical Subject Headings, MeSH terms "(oral cancer OR oral neoplasm) AND (Mexico) AND (epidemiology OR prevalence)" and the equivalent keywords in Spanish.