Orbital and intracranial metastasis secondary to thyroid carcinoma.

INTRODUCTION: An exponential increase in thyroid cancer has been reported in Mexico with 12,122 new cases in 2018 it represents the most common endocrinological cancer described by the World Health Organization. Attributing it local and distant metastatic lesions, being unusual the orbital condition. CLINICAL CASE: A 56-year-old woman diagnosed with chronic myeloid leukemia 19 years ago, presented with left eye proptosis and tearing, headaches, worsening left facial neuralgia. CONCLUSIONS: In these cases, the surgical treatment is essential to improve patient's symptoms and quality of life.

INTRODUCCIÓN: En México existe un aumento exponencial del cáncer de tiroides, con 12,122 nuevos casos en 2018, representando el cáncer endocrinológico más frecuente descrito por la Organización Mundial de la Salud. Se le atribuyen lesiones metastásicas locales y a distancia, siendo una presentación inusual la afección orbitaria. CASO CLÍNICO: Mujer de 56 años diagnosticada de leucemia mieloide crónica hace 19 años, que acude por cefalea, proptosis e hiperemia conjuntival con limitación a la abducción, y dolor facial izquierdo. CONCLUSIONES: En estos casos, el tratamiento quirúrgico es indispensable para mejorar la sintomatología y la calidad de vida del paciente.

A new species of Plestiodon (Squamata: Scincidae) from the Balsas Basin, Mexico.

We describe a new species of Plestiodon in the P. brevirostris group from the Balsas Basin in central Mexico. It is distinguished from the other species in the group by the following combination of traits: supraoculars four; interparietal enclosed posteriorly by parietals; primary temporal present; seventh supralabial usually contacting upper secondary temporal; longitudinal dorsal scale rows around midbody 23-26; Toe-IV lamellae 13-15; limbs not overlapping when adpressed against body; dorsolateral light line extending posteriorly to level of posterior end of anterior fourth of body or beyond; light median line absent in all growth stages; primary lateral dark lines separated medially by six dorsal scale rows and upper half of adjacent row on each side at level of midbody; lower secondary dark line faint at level of neck; and light coloration of supralabials extending ventrally to lip border. Analyses based on DNA sequences of three loci support the distinctiveness of the new species, as well as its sister species relationship with P. ochoterenae. The Environmental Vulnerability Score of the new species places it in the high vulnerability category.

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

The structure-activity relationship of the O-benzyl serine side chain was investigated based on the tetrazole-based growth hormone secretagogue BMS-317180 (2). The ortho position of the benzyl moiety was found to be favorable for introduction of substituents. A series of ortho-substituted compounds were synthesized with improved in-vitro and in-vivo activity. Among them, the biphenyl compound 2p shows twofold improvement in potency compared to its parent compound BMS-317180 (2).