Bupivacaine liposomal injectable suspension does not provide improved pain control in dogs undergoing abdominal surgery.

OBJECTIVE: To evaluate the difference in postoperative pain scores of dogs undergoing abdominal surgery receiving surgical incision infiltration of saline or bupivacaine liposomal injectable suspension (BLIS). ANIMALS: 40 dogs undergoing exploratory laparotomy. METHODS: Dogs were prospectively enrolled and randomized to receive either BLIS or saline surgical incision infiltration. All dogs received 5.3 mg of BLIS/kg or an equal volume of saline infiltrated in the muscle/fascia, subcutaneous tissue, and intradermal layer during closure. All dogs received a standardized postoperative pain management protocol. Pain assessment was performed at select time points postoperatively by blinded observers with an electronic algometer, short version of the Glasgow Composite Measure Pain Scale (GCMPS), and indirect measures of pain, including systolic blood pressure, heart rate, and serum cortisol levels. RESULTS: At day 0, blood pressure was higher in the saline group (149.6 vs 125.8 mm Hg; P = .006). At day 3, GCMPS was lower in the BLIS group (BLIS = 1, saline = 2, P = .027), though both average GCMPS scores were low and only 10 dogs were available for day 3 assessments (6 BLIS and 4 saline). No other differences in algometer readings, GCMPS scores, other measured parameters, or need for rescue analgesia were present between BLIS and saline groups at any time point. There was no difference in postoperative incisional infection rate or complications. CLINICAL RELEVANCE: Use of BLIS for exploratory laparotomy did not provide improved pain control over postoperative opioid administration alone. Patients that received BLIS had no increase in short-term complications.

Risk factors for gastrointestinal upset and evaluation of outcome following surgical resection of canine pancreatic ß-cell tumors.

The objective of this study was to determine risk factors for vomiting and inappetence and evaluate long-term outcome after surgical treatment of pancreatic ß-cell tumors in dogs. Records of 33 dogs that underwent surgery for such tumors were retrospectively evaluated. Inappetence and vomiting occurred in 27.3% and 24.2% of dogs, respectively. Risk factors for postoperative vomiting were longer duration of clinical signs before surgery, higher preoperative total protein concentration, and lack of liver metastasis. No significant risk factors for inappetence or survival were identified. Median survival time was 723 days. Dogs with a longer duration of clinical signs before surgery may have had greater pancreatic involvement or more pronounced systemic perturbations. Higher preoperative total protein concentration may reflect preoperative dehydration or inflammation. Significance of lack of liver metastasis is unknown. The long survival time indicates a good overall prognosis with surgical treatment, justifying surgical intervention in patients with advanced disease.

Facteurs de risque pour les dérangements gastro-intestinaux et évaluation des résultats à la suite de la résection chirurgicale de tumeurs des cellules ß pancréatiques canines. L'objectif de la présente étude était de déterminer les facteurs de risque pour les vomissements et l'inappétence, et d'évaluer les résultats à long terme à la suite du traitement chirurgical de tumeurs des cellules ß pancréatiques chez des chiens. Les dossiers de 33 chiens qui subirent une chirurgie pour de telles tumeurs furent évalués rétrospectivement. L'inappétence et des vomissements se produisirent chez 27,3 % et 24,2 % des chiens, respectivement. Les facteurs de risque pour des vomissements post-opératoires étaient une durée plus longue des signes cliniques avant la chirurgie, une concentration pré-opératoire des protéines totales plus élevée, et l'absence de métastase hépatique. Aucun facteur de risque significatif pour l'inappétence ou la survie ne fut identifié. La médiane du temps de survie était de 723 jours. Les chiens avec une durée plus longue de signes cliniques avant la chirurgie pourraient avoir eu une plus grande atteinte pancréatique ou des perturbations systémiques plus prononcées. Des concentrations pré-opératoires de protéines totales plus élevées pourraient refléter une déshydratation pré-opératoire ou de l'inflammation. La signification de l'absence de métastase hépatique est inconnue. Le temps de survie prolongé indique un bon pronostic général avec le traitement chirurgical, justifiant ainsi l'intervention chirurgicale chez des patients dont la maladie est à un stade avancé.(Traduit par Dr Serge Messier).