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1.
Tidsskr Nor Laegeforen ; 144(6)2024 May 14.
Artigo em Inglês, Norueguês | MEDLINE | ID: mdl-38747663

RESUMO

Background: Chagas encephalitis is a rare but severe manifestation of reactivation in patients with chronic Chagas disease. Case presentation: A woman in her seventies who was immunosuppressed after a heart transplant due to Chagas disease was admitted with convulsions, headache and visual disturbances. She developed fever, confusion and repeated convulsions. Pleocytosis was found in spinal fluid. Wet-mount microscopy of spinal fluid revealed motile Trypanosoma cruzi trypomastigotes, and multiple trypomastigotes were seen on a Giemsa-stained smear, confirming reactivation of Chagas disease with meningoencephalitis. Despite benznidazole treatment, she deteriorated, exhibiting pharyngeal paralysis, aphasia and increasing somnolence. Brain CT showed pathology consistent with Chagas encephalitis. Nifurtimox was given as an adjunctive treatment. After a week of treatment, the patient began to improve. She completed 60 days of benznidazole and had regained normal cognitive and neurological function on subsequent follow-up. She had no signs of myocarditis reactivation. Interpretation: Chronic Chagas disease is common among Latin American immigrants in Europe. Reactivation with myocarditis after a heart transplant is well known, while encephalitis is a rare manifestation. We report on a case of Chagas encephalitis in an immunosuppressed patient. Microscopy of parasites in spinal fluid revealed the diagnosis. The WHO provided antiparasitic medications, and despite a severe prognosis, the patient made a full recovery.


Assuntos
Convulsões , Humanos , Feminino , Convulsões/etiologia , Convulsões/tratamento farmacológico , Idoso , Febre/etiologia , Doença de Chagas/tratamento farmacológico , Tripanossomicidas/uso terapêutico , Hospedeiro Imunocomprometido
2.
Tidsskr Nor Laegeforen ; 131(1): 20-3, 2011 Jan 07.
Artigo em Norueguês | MEDLINE | ID: mdl-21233882

RESUMO

BACKGROUND: Burn injuries in children may cause permanent harm. This study reports data on incidence, injury mechanisms and products that cause burn injuries (in the period 01.01.07-31.12.07) and compares findings with those from previous studies (in 1989 and 1998). MATERIAL AND METHODS: Semi-structured questionnaires were filled in by patients or next-of-kin and health workers at Bergen Accident and Emergency Department, casualty centres in three municipalities in western Norway (Fana, Åsane and Loddefjord) and at the National Burns Centre, Haukeland University Hospital. Missing data were retrieved retrospectively from medical records. RESULTS: We recorded 142 children with burn injuries; 35% were boys under two years of age. The annual incidence was the same as earlier; 6.6 per 1,000 under five years and 3.1 per 1,000 children under 15 years living in the community of Bergen. Contact injuries and scalds were most common and were caused by contact with ovens, stoves and hot food or liquids. Most children (93%) had less severe burns; 6% (9) were hospitalized (four of them had a non-western background). Almost 95% were given first aid by cooling. INTERPRETATION: Children under two years, especially boys, are most at risk of burn injuries. Ovens were the cause more often now than before. The incidence has been the same the last 20 years and is the same as that in Trondheim ten years ago. The fact that the small city, Harstad, (northern Norway) attained substantially less injuries after the introduction of preventive actions indicates that such actions are needed to reduce the number of burn injuries among children.


Assuntos
Queimaduras/epidemiologia , Acidentes Domésticos/estatística & dados numéricos , Adolescente , Queimaduras/etnologia , Queimaduras/etiologia , Queimaduras/terapia , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Lactente , Masculino , Noruega/epidemiologia , Noruega/etnologia , Estudos Retrospectivos , Fatores de Risco , Inquéritos e Questionários
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