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1.
Children (Basel) ; 10(2)2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36832328

RESUMO

Due to poor results, the German talent identification and development of the German soccer association DFB no longer performs a shooting test since a few years. The aim of this study was to create and validate a new soccer shooting test that allows valid conclusions to be drawn from the shooting quality of youth soccer players about their overall soccer skills. The shooting test was performed with a total of 57 male club players (age: 15.24 ± 0.864 years) from four different teams from the first, second, fifth, and the seventh division of the respective age group (under 15-year-olds until under 17-year-olds). Each subject took one shot at maximum shot speed and eight target shots, measuring accuracy and the shot speed. A multivariable linear regression analysis with forward selection revealed significant values for the variables average shot speed nondominant leg (p < 0.001) and total score (p = 0.004; accuracy × speed of every target shot). Based on these two variables, the soccer skills could be derived from the shooting skills of the adolescents in 57.4% of the cases. The study shows the importance of a good technique with the nondominant leg and of the ability to shoot accurately as well as fast simultaneously.

2.
Front Physiol ; 14: 1267804, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38162829

RESUMO

Purpose: For systematic athletic training and targeted talent development, it is essential to know the physical fitness and motor competencies of top athletes in detail. However, it can be difficult to identify differences in performance requirements and thus to provide adequate support, especially for sports that at first glance appear to have similar demands-such as track and field throwing disciplines. Therefore, the aim of the study was to examine the physical fitness and motor competence of top athletes from different throwing disciplines and to check whether the athletes' performance parameters match the specific requirements of the respective sport. Methods: The study involved 289 male youth athletes (aged 14-18 years) across four distinct throwing disciplines: shot put (n = 101), hammer throw (n = 16), discus throw (n = 63), and javelin throw (n = 109). The performance evaluation comprised three anthropometric measurements and twelve motor performance prerequisites applicable to the throwing disciplines. Discriminant analysis and neural networks (Multilayer Perceptron) were implemented to determine the possibility of distinguishing among athletes from the four sports. Results: The study's findings indicate that in male throwing athletes, disparities in general physical fitness and motor proficiency assessments discern the majority of talented young athletes based on their specific sport (discriminant analysis: 68.2%; multilayer perceptron analysis: 72.2%). This remains applicable irrespective of the classification method employed. Discus throwers possessed a height advantage, while shot putters and hammer throwers exhibited superior arm strength. Javelin throwers displayed better explosive strength and sprinting speed. Except for the hammer throwers, all events demonstrated a high level of explosive power in the medicine ball forward or backward throw test, which was especially crucial for shot put and discus athletes. Conclusion: The significance of physical fitness and motor competence tests in identifying and transferring talented athletes in track and field throwing disciplines has been affirmed. Using linear and non-linear classification methods, most athletes could be assigned to their correct sport. However, this also shows that slightly different training and talent identification is required for each of these sports. Furthermore, non-linear analysis methods can provide useful support for the development processes in junior competitive sports.

3.
Artigo em Inglês | MEDLINE | ID: mdl-36141896

RESUMO

Purpose: This study investigated the most recent estimates of underweight, overweight, and obesity prevalence in Pakistani school-aged children and adolescents. Methods: A cross-sectional study was conducted using a convenience random clustered sampling approach with 3,551 Pakistani school children aged 9 to 17 years from 52 schools throughout seven districts in central Punjab province. The CDC US 2000 was used to define underweight (BMI < 5th percentile), overweight (85th ≤ BMI < 95th percentile), and obesity (95th percentile ≤ BMI) for different school grade cohorts (primary, middle, secondary, and higher secondary schools). As a trend test, the Chi-square test was used. A Spearman correlation analysis (r) was used to determine the correlations between demographic variables and weight status. A regression analysis was conducted to explore the predictive power of demographic factors in relation to body weight. Results: In Pakistani school-aged children and adolescents, the prevalence of underweight, normal weight, overweight, and obesity was 21.9%, 66.9%, 5.8%, and 5.4%, respectively. Significant correlations with body weight status were shown for individual demographic parameters (age, gender, school type, and school grade). Children in urban areas were more likely to be underweight, overweight, or obese than those in rural areas. Boys were found to have a lower BMI than girls. Accordingly, more boys than girls were underweight (odds ratio (OR) = 1.57, 95% CI: 1.33-1.85) and more girls had a higher risk of obesity than boys (OR = 1.39, 95% CI: 1.03-1.86). Lower grades showed more underweight (OR = 1.66, 95% CI: 1.39-1.99) whereas higher grades showed a higher risk of obesity (OR = 1.91, 95% CI: 1.41-2.57). Conclusions: In Pakistani school-aged children and adolescents, underweight, overweight, and obesity were prevalent. Compared with studies from 2011, the risk of overweight and obesity in Pakistan has decreased. However, this may also be due to the fact that students in Pakistan have a lower BMI compared to other countries. This issue has also been seen in the present study and is confirmed here by the high number of cases of underweight students. Future research studies should look into additional weight status correlates and factors. To evaluate the association between weight status and behavioral and other health variables, future research should use longitudinal or interventional designs.


Assuntos
Sobrepeso , Magreza , Adolescente , Índice de Massa Corporal , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Paquistão/epidemiologia , Prevalência , Magreza/epidemiologia
4.
Artigo em Inglês | MEDLINE | ID: mdl-35955059

RESUMO

Background: For high performance in sport climbing, various factors must be taken into account, however, social interactions during climbing sessions have not yet been considered. Methods: For this study, four assumptions were made: (1) elite climbers share similar patterns of behaviour; (2) these behaviour patterns influence the climbing performance in a positive way; (3) the behaviour patterns had to be formed over time, and the process of changing behaviour was catalysed by formative experiences; and, (4) the social behaviour of elite climbers shows a tendency to be on their own rather than in the centre of social events, while their behavioural roots date back to their school life. Six male higher-elite-level climbers participated in semi-structured in-depth interviews. Results: In school, all participants perceived themselves as not being at the centre of social interactions. Moreover, all participants described a development from egoistic behaviour towards more supportive behaviour. Two participants were able to outline specific, formative experiences (crucibles), that drastically shaped their behaviour. Conclusion: All participants performed best in the absence of social tensions and when the atmosphere between the climbing partners was positive. Positive atmosphere was achieved by finding the optimal personal balance between supportive and egoistic behaviour.


Assuntos
Montanhismo , Esportes , Humanos , Masculino , Comportamento Social
5.
J Sport Exerc Psychol ; 44(4): 251-262, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35453117

RESUMO

Using latent profile analysis and self-determination theory, the present study aimed to examine younger children's motivation profiles in sports and physical activities and the relations of those profiles to various predictors and achievement outcomes. A total of 1,116 German children from Grade 2 participated in this study. Latent-profile-analysis solutions based on five behavioral-regulation types covered in self-determination theory (i.e., intrinsic, identified, introjected, external, amotivation) were tested. Results favored a three-profile solution, showing three theoretically meaningful and distinct motivation profiles labeled "amotivated," "non-self-determined," and "self-determined." Older children and children with a lower physical self-concept were more likely to be members of the amotivated profile relative to the other profiles than younger children and children with a higher physical self-concept. Furthermore, children of the self-determined profile demonstrated the best physical performance in various motor-skills tests.


Assuntos
Motivação , Esportes , Logro , Adolescente , Criança , Humanos , Autonomia Pessoal , Autoimagem
6.
Children (Basel) ; 8(11)2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34828759

RESUMO

Being physically fit in younger years prevents several diseases in the presence as well as in the life course. Therefore, monitoring physical fitness and motor competence through motor testing is essential for determining developmental status and identifying health-related risks. The main objectives of this systematic review were (1) to identify currently available health-related criterion-referenced standards and cut-off points for physical fitness and motor competence test items, (2) to frame the methodological background on setting health-related criterion-referenced standards and (3) to give implications for a health-related evaluation system for physical fitness and motor competence tests. The electronic data base search (PubMed, Web of Science and SURF) yielded 2062 records in total and identified six empirical studies reporting cut-off points of motor test items for children (7-10 years), as well as 30 methodological papers discussing determination approaches to health-related criterion-referenced standards. Data collection, selection and analyses followed the PRISMA guidelines. Health-related motor test standards need to be gender- and age-specific but should refer to an absolute cut-off point rather than to relative performance in the reference group. Due to the lack of data on health-related criterion referenced standards, receiver-operating-characteristic (ROC) curves provide a tool for the determination of cut-off points and criterion referenced standards for physical fitness and motor competence tests. A standardized approach forms the fundamental base for a globally applicable evaluation of health-related fitness tests.

7.
Front Sports Act Living ; 3: 625645, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34151260

RESUMO

Several talent identification programs in elementary school have implemented motor diagnostics to introduce children to groups of sports, like game sports, or even to particular sports like soccer. However, as in most other sports, in youth soccer, the predictive value of such early testing is still unclear. This prospective study evaluated the midterm prognostic validity of generic motor performance tests. The sample consisted of male second-grade children, which had received a recommendation to participate in soccer. The talent screening campaign was a basic check comprising two anthropometric parameters, five physical fitness, and three motor competence diagnostics of the German Motor Test 6-18. The test data were collected from the participating elementary school classes of the years 2010 to 2014. The soccer competition performance of those children having completed the age of at least 15 years (n = 502) up to the end of the season 2019/2020 (2020, September 30) was recorded. This group of U17 players was then assigned individually to five different competition levels. The prognostic validity of the physical and physiological tests was determined using ANOVAs, odds ratios, and a regression path analysis. All diagnostic methods exhibited medium-to-high prognostic validity over the 8 year time span from the talent screening to the later soccer competitions in the adolescent age groups. For later success in soccer on the province level, the 6-min run (OR = 4.28), dynamic balance (OR = 4.04), and 20-m sprint (OR = 2.46), as well as the participation in the training center of the German Soccer Federation (OR = 5.67) and the diversity of club sport activities (OR = 3.56), were of particular importance.

8.
Children (Basel) ; 8(5)2021 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-34068840

RESUMO

(1) Background: Children with greater physical activity (PA) may show a higher physical fitness (PF) and motor competence (MC) compared to peers with less PA. The purpose of this study was to examine the relationship between moderate-to-vigorous physical activity (MVPA), PF, and MC in 8- to 9-year old children in Germany and China. MVPA was differentiated into five PA settings: family sport, club training, school sport, leisure sport, and outside play. (2) Methods: This longitudinal study comprised N = 577 children (n = 311 girls, n = 266 boys) who were studied over a one-year period. Each child's PF and MC was determined using sports motor tests. The children's PAs were measured using a questionnaire. (3) Results: The children's PA was positively associated with PF and MC. The MVPA-settings: family sport, leisure sport, outside play, school, and club sport, explained between 18 and 23 percent of the variance in selected PF and MC characteristics in a multivariate linear regression analysis. (4) Conclusions: An increase in the children's MVPA might be an appropriate aim in the school sport in Germany as well as in the club sport system in China. Furthermore, family sport should be enhanced in Germany and outside play activities in China, respectively.

9.
Front Psychol ; 12: 669936, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33995228

RESUMO

The present study aimed to examine the relations between physical self-concept, intrinsic and extrinsic motivation as well as physical performance of 1,082 children aged 7-8 years. The central objective of this study was to contrast a mediation model assuming physical self-concept as a mediator of the relations between both types of motivation and physical performance to a mediation model assuming both types of motivation as mediators of the relations between physical self-concept and physical performance. Physical self-concept and both types of motivation were measured by using self-reported questionnaires, while physical performance was measured with 10 motor skill tests. All tests were carried out during regular school hours (8-12 A.M.) by qualified test personnel. Beyond correlation analyses, structural equation modeling (SEM) was performed to find evidence for the predictive relations between the variables under study. Results showed that physical self-concept was significantly positively related to both types of motivation and physical performance (all p < 0.001). In contrast, results of SEM revealed that only physical self-concept (p < 0.001) and intrinsic motivation (p < 0.05) were significantly positively linked to physical performance. Furthermore, physical self-concept proved to significantly mediate the relations of both types of motivation to physical performance (p < 0.001), while only intrinsic motivation, but not extrinsic motivation, proved to significantly mediate the relation between physical self-concept and physical performance (p < 0.05). These results suggest that school-based or extracurricular interventions targeted at improving younger children's physical performance only by means of an increased level of physical activity or by external factors without supporting children's physical self-concept and intrinsic motivation may have less or no effects on their physical performance.

10.
J Sports Sci ; 39(4): 368-379, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32972318

RESUMO

A talent identification index system for male and female cross-country skiers in four age groups (11-12 years old, 13-14 years old, 15-16 years old, and 17-18 years old) was established. The system comprises five body shape indexes ( i =5): Leg-to-Body Ratio (LBR), body fat percentage, maturity status, spreaded brachia index, and upper extremity length. The physiological function indexes ( i =2) are VO2max and haemoglobin mass (Hb). The psychological indexes ( i =5) cover reaction time, perception speed, a quality-of-will scale, an attention test, and operational thinking. The physical fitness indexes ( i =11) comprise upper limb explosiveness, vertical jump, 3000-metre run, orthostatic forward flexion, closed-eyes single-leg stand, standing long jump, 20-metre sprint, pull-ups (males), flexed arm hang (females), hexagon jump, and a Functional Movement Screen (FMS) test. The athletic performance indexes ( i =3) comprise on-snow time trials for 1.2 km, 5 km, and 10 km. The talent identification evaluation model was created using automated evaluation software. The talent identification index system and evaluation standard table for cross-country skiers passed the P60 shortlist and P90 elite boundaries established using the percentile method. Thus, the results of this test profile verify that the evaluative model is objectively effective.


Assuntos
Aptidão , Esqui/fisiologia , Esqui/psicologia , Adiposidade/fisiologia , Adolescente , Desempenho Atlético/fisiologia , Atenção/fisiologia , Estatura/fisiologia , Criança , China , Análise de Dados , Técnica Delphi , Estudos de Avaliação como Assunto , Teste de Esforço/métodos , Feminino , Hemoglobina A/análise , Humanos , Masculino , Modelos Teóricos , Percepção de Movimento/fisiologia , Consumo de Oxigênio/fisiologia , Aptidão Física/fisiologia , Desempenho Físico Funcional , Equilíbrio Postural/fisiologia , Tempo de Reação , Corrida/fisiologia , Fatores Sexuais , Somatotipos/fisiologia , Pensamento , Fatores de Tempo , Extremidade Superior/anatomia & histologia , Volição/fisiologia
11.
PLoS One ; 15(10): e0239155, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33044967

RESUMO

Training in elite sport aims at the optimization of the athletic performance, and to control the athletes`progress in physiological, anthropometrical and motor performance prerequisites. However, in most sports, the value of longitudinal testing is unclear. This study evaluates the longitudinal development and the influence of intense training over 2-years on specific physiological performance prerequisites, as well as certain body dimensions and motor abilities in elite youth athletes. Recruited between 11-13 years of age at Shanghai Elite Sport school, the sample of student-athletes (N = 21) was categorized as the swimming group (10 athletes), and the racket sports group (11 players: 7 table tennis and 4 badminton players). The performance monitoring took place over two years between September 2016 and September 2018 and included 5 test waves. In all the test waves, the athletes were assessed by means of three physiological measurements (vital capacity, hemoglobin concentration, heart rate at rest), three anthropometric parameters (body height, body weight, chest girth), and two motor tests (back strength, complex reaction speed). Seven out of eight diagnostic methods exhibit medium to high validity to discriminate between the different levels of performance development in the two sports groups. The investigated development of the performance characteristics is attributed partly to the inherited athletic disposition as well as to the different sport-specific training regimens of the two sports groups.


Assuntos
Atletas , Desempenho Atlético/fisiologia , Esportes com Raquete/fisiologia , Natação/fisiologia , Adolescente , Antropometria , Criança , China , Seguimentos , Frequência Cardíaca , Hemoglobinas/metabolismo , Humanos , Estudos Longitudinais , Masculino , Destreza Motora , Força Muscular , Tempo de Reação , Capacidade Vital
12.
Front Physiol ; 10: 405, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31105576

RESUMO

Several talent selection programs in elite sport schools are based on motor diagnostics for the purpose of recommending or transferring promising talents to general groups of sports; game sports, combat sports or endurance sports, and to more concrete sports such as gymnastics, skiing, or tennis. However, the predictive value of such testing is unclear. This study evaluated the concurrent validity of physiological performance prerequisites, body dimensions, as well as specific motor performances. The sample consisted of N = 97 youth athletes from all ninth grade classes of a Shanghai Elite Sport school belonging to six different sports including basketball (n = 7), fencing (n = 23), judo (n = 20), swimming (n = 10), table tennis (n = 15), and volleyball (n = 22). The performance diagnosis took place between September 2016 and March 2017, and comprised five physiological measurements of the heart rate at rest, vital capacity, systolic and diastolic blood pressure, and hemoglobin concentration in the blood, eighteen anthropometric parameters, and two motor tests on back strength and complex reaction speed. The aim of the study was to investigate whether U15 age group athletes participating in six different sports already at this age show a sport specific anthropometric, motor performance, and physiological profile which is in line with the specific requirements of each of the sports. A discriminant analysis and a Neural Network (Multilayer Perceptron) were used to test whether it is possible to discriminate between athletes of the six sports and to assign each individual of the Under-15 athletes to his own sport on the basis of a unique profile of the morphological, motor, and physiological prerequisites. All diagnostic methods exhibited medium to high validity to discriminate between the six different sports. The relevance of the eighteen body dimensions, five physiological measures, and two motor tests for talent identification was confirmed.

13.
Front Physiol ; 9: 251, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29618981

RESUMO

Elite endurance athletes are characterized by markedly increased hemoglobin mass (Hbmass). It has been hypothesized that this adaptation may occur as a response to training at a very young age. Therefore, the aim of this study was to monitor changes in Hbmass in children aged 8-14 years following systematic endurance training. In the first study, Hbmass, VO2max, and lean body mass (LBM) were measured in 17 endurance-trained children (13 boys and 4 girls; aged 9.7 ± 1.3 years; training history 1.5±1.8 years; training volume 3.5 ± 1.6 h) twice a year for up to 3.5 years. The same parameters were measured once in a control group of 18 age-matched untrained children. Hbmass and blood volume (BV) were measured using the optimized CO-rebreathing technique, VO2max by an incremental test on a treadmill, and LBM by skin-fold measurements. In the second pilot study, the same parameters were measured in 9 young soccer athletes (aged 7.8 ± 0.2 years), and results were assessed in relation to soccer performance 2.5 years later. The increase in mean Hbmass during the period of study was 50% which was closely related to changes in LBM (r = 0.959). A significant impact of endurance training on Hbmass was observed in athletes exercising more than 4 h/week [+25.4 g compared to the group with low training volume (<2 h/week)]. The greatest effects were related to LBM (11.4 g·kg-1 LBM) and overlapped with the effects of age. A strong relationship was present between absolute Hbmass and VO2max (r = 0.939), showing that an increase of 1 g hemoglobin increases VO2max by 3.6 ml·min-1. Study 2 showed a positive correlation between Hbmass and soccer performance 2.5 years later at age 10.3 ± 0.3 years (r = 0.627, p = 0.035). In conclusion, children with a weekly training volume of more than 4 h show a 7% higher Hbmass than untrained children. Although this training effect is significant and independent of changes in LBM, the major factor driving the increase in Hbmass is still LBM.

14.
J Sports Sci ; 35(8): 806-811, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27267568

RESUMO

This retrospective study focuses on the comparison of different predictive models based on the results of a talent identification test battery for female gymnasts. We studied to what extent these models have the potential to optimise selection procedures, and at the same time reduce talent development costs in female artistic gymnastics. The dropout rate of 243 female elite gymnasts was investigated, 5 years past talent selection, using linear (discriminant analysis) and non-linear predictive models (Kohonen feature maps and multilayer perceptron). The coaches classified 51.9% of the participants correct. Discriminant analysis improved the correct classification to 71.6% while the non-linear technique of Kohonen feature maps reached 73.7% correctness. Application of the multilayer perceptron even classified 79.8% of the gymnasts correctly. The combination of different predictive models for talent selection can avoid deselection of high-potential female gymnasts. The selection procedure based upon the different statistical analyses results in decrease of 33.3% of cost because the pool of selected athletes can be reduced to 92 instead of 138 gymnasts (as selected by the coaches). Reduction of the costs allows the limited resources to be fully invested in the high-potential athletes.


Assuntos
Aptidão , Análise Discriminante , Ginástica/economia , Redes Neurais de Computação , Custos e Análise de Custo , Feminino , Humanos , Estudos Retrospectivos
15.
Hum Mov Sci ; 31(2): 344-59, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21315468

RESUMO

Training science views itself as an integrated and applied science, developing practical measures founded on scientific method. Therefore, it demands consideration of a wide spectrum of approaches and methods. Especially in the field of competitive sports, research questions are usually located in complex environments, so that mainly field studies are drawn upon to obtain broad external validity. Here, the interrelations between different variables or variable sets are mostly of a nonlinear character. In these cases, methods like neural networks, e.g., the pattern recognizing methods of Self-Organizing Kohonen Feature Maps or similar instruments to identify interactions might be successfully applied to analyze data. Following on from a classification of data analysis methods in training-science research, the aim of the contribution is to give examples of varied sports in which network approaches can be effectually used in training science. First, two examples are given in which neural networks are employed for pattern recognition. While one investigation deals with the detection of sporting talent in swimming, the other is located in game sports research, identifying tactical patterns in team handball. The third and last example shows how an artificial neural network can be used to predict competitive performance in swimming.


Assuntos
Aptidão , Comportamento Competitivo , Redes Neurais de Computação , Reconhecimento Automatizado de Padrão , Educação Física e Treinamento , Ciência , Esportes/educação , Natação/educação , Adolescente , Algoritmos , Desempenho Atlético , Criança , Feminino , Alemanha , Humanos , Modelos Lineares , Estudos Longitudinais , Masculino , Destreza Motora , Dinâmica não Linear , Pesquisa , Estatística como Assunto
16.
Cranio ; 26(1): 33-43, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18290523

RESUMO

The objectives of this retrospective study were to systematically assess the temporomandibular joint (TMJ) using a newly developed standardized evaluation form with 16 parameters based on MRI diagnostics and to verify the reliability of the MRI diagnoses. One hundred fifty-four (154) TMJs of 77 patients with arthrogenic complaints were evaluated using MRI on two planes (parasagittal, paracoronal), in both closed-mouth and open-mouth positions. The sequences used were intermediary FLASH and spin echo sequences using T1 or T2 weighting with fat suppression. Examination of the reliability of the MRI evaluations of three independent observers evaluating 60 randomly selected TMJ from among the overall sample using the new evaluation form yielded an average Pearson contingency coefficient of between 0.64 and 0.70 with regard to the 16 parameters studied. In the evaluation of the 77 left (L) and 77 right (R) joints, the biplanar morphology of the disk was the most frequent with 24.7% (L) and 32.5% (R). In paracoronal projection, medial displacement of the disk was seen in 7.9% (L, R) of the cases and lateral displacement in 6.4% (L) and 3.2% (R). The use of the new evaluation form, in combination with MRI of the TMJ, demonstrated a substantial reliability of the diagnoses. In TMD patients, the biconcave disk shape cannot be considered the sole normal, standard situation. The presence of lateral and medial disk displacement should be given more diagnostic consideration.


Assuntos
Imageamento por Ressonância Magnética/métodos , Articulação Temporomandibular/patologia , Adulto , Métodos Epidemiológicos , Feminino , Humanos , Luxações Articulares/diagnóstico , Masculino , Côndilo Mandibular/patologia , Côndilo Mandibular/fisiopatologia , Articulação Temporomandibular/fisiopatologia , Disco da Articulação Temporomandibular/patologia , Disco da Articulação Temporomandibular/fisiopatologia
17.
Chemistry ; 10(18): 4584-93, 2004 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-15378637

RESUMO

The dibromoalkenes (S)-3 and (R)- and (S)-4 are intermediates in the syntheses of the naturally occurring fungicidal butenolides fugomycin (1) and desoxyfugomycin (2), respectively. The stereoselective bromine-lithium exchange that leads to the carbenoid 12 and the vinyllithium reagent 17 a on the one hand, and palladium-catalyzed coupling reactions of the dibromoalkene 3 and the bromolactone 22 on the other are key steps en route to the butenolides 1 and 2. The chiral building blocks (S)-3, (R)-4, and (S)-4 are readily available from (R)-isopropylideneglyceraldehyde 5, isobutyl (R)-lactate 6 a, and ethyl (S)-lactate 6 b, respectively. The synthetic procedure adopted here permits the absolute configuration of the natural products fugomycin (1) and desoxyfugomycin (2) to be assigned by comparison of their chiroptical properties with those of the synthetic products. The CD spectra of the bromolactone 22, calculated by two different density functional methods (TDDFT, DFT/MRCI), are found to be in good agreement with the measured spectra. On the basis of these calculations, the two CD bands observed could be assigned to n-pi* and pi-pi* transitions, respectively. Fugomycin (1) and the synthetic butenolide 20 displayed high fungicidal activity against botrytis in greenhouse experiments, whereas the saturated lactone 21 was practically inactive.


Assuntos
4-Butirolactona/análogos & derivados , Alcenos , Antifúngicos , Lactonas , 4-Butirolactona/síntese química , 4-Butirolactona/química , 4-Butirolactona/farmacologia , Alcenos/síntese química , Alcenos/química , Alcenos/farmacologia , Antifúngicos/síntese química , Antifúngicos/química , Antifúngicos/farmacologia , Botrytis/efeitos dos fármacos , Dicroísmo Circular , Lactonas/síntese química , Lactonas/química , Lactonas/farmacologia , Estrutura Molecular
18.
Chaos ; 7(2): 221-228, 1997 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12779650

RESUMO

We propose a method to explore invariant measures of dynamical systems. The method is based on numerical tools which directly compute invariant sets using a subdivision technique, and invariant measures by a discretization of the Frobenius-Perron operator. Appropriate visualization tools help to analyze the numerical results and to understand important aspects of the underlying dynamics. This will be illustrated for examples provided by the Lorenz system. (c) 1997 American Institute of Physics.

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