Correlation of IDH1 gene expression error in breast tumor biopsy in patients with invasive ductal carcinoma.

One of the most important cancers in terms of worldwide prevalence is breast tumors, which have been less investigated in correlation with the enzyme Isocitrate Dehydrogenase 1 (IDH1) gene. The aim of this study was that expression of this gene could have significant effects on the progression of metastasis and invasive disease in breast cancer patients. We used the molecular method of RT-PCR with SYBR-Green to analyze breast tumor tissue from patients with metastasis and non-metastasis, the latter confirmed by the pathology department of Shohada-e Tajrish Hospital (serving as a control group). Also, patients population and its relationship with the degree of tumor in the IDH1 gene was investigated. The IDH1 gene has shown high expression in patients with metastatic breast cancer rather than in patients with non-metastatic breast cancer. The metastatic samples were compared with non-metastatic samples for IDH1 mRNA expression. In this research work, 72.5% (29 samples) were up-regulated in comparison to 27.5% of samples (11 samples) that did not exhibit high expression (P=0.000).  This study examined the IDH1 gene expression, suggesting that changes in this gene's expression could impact the prognosis of breast cancer. However, further research is needed to draw definitive conclusions.

The evaluation of a composed program of continuing medical education for general practitioners.

INTRODUCTION: The execution of composed educational programs for general practitioners is one of the most common methods of continuing medical education. This research project aims to evaluate one of these programs. METHODS: For this purpose, a pre- and post-test design was developed. The subjects consisted of 45 participants. They were tested in two stages: before and after the program. A questionnaire was also used to gather the participants' views on four variables including teachers' behavior, the degree of achieving the objective of the program, objective of the learner, and satisfaction with the program. RESULTS: Based on the results of this study, the mean scores of the participants' knowledge increased from 10.05 (pre test) to 12.61 (post test), (p<0.0001). In addition, the results showed that the teachers' behavior and satisfaction with the program were rated by participants as the highest and least, respectively. CONCLUSION: The results of this research are indicative of the effectiveness of the composed educational program in continuing medical education. Nevertheless, such programs are recommended to be further evaluated with more rigorous design.