Is smokeless tobacco use associated with lower health-related quality of life? A cross-sectional survey among women in Bangladesh.

INTRODUCTION: Bangladesh has 22 million adult users of smokeless tobacco (ST). The prevalence among women is higher (24.8%). Health-related quality of life outcome (HRQoL) for ST use is little known. We investigated the association between HRQoL and daily ST use among adult women in Bangladesh. METHODS: Using multi-stage design, a cross-sectional survey was conducted. Adult women (randomly selected) were surveyed from 4 purposively selected divisions (Dhaka, Chittagong, Khulna and Rangpur). Female ST users and non-users were compared using HRQoL scores. Self-perceived Visual Analogue Scale (EQ-VAS) values and HRQoL scores were modelled to examine their association with ST use. RESULTS: A total of 2610 women (1149 users and 1461 non-users) were surveyed. The proportion reported any type of problem in all health dimensions was significantly higher among female ST users than non-users (mobility: 43.3% vs 19.5%, self-care: 29.6% vs 11.9%, usual activities: 48.7% vs 21.8%, pain or discomfort: 69.8% vs 40.6%, and anxiety or depression: 61.3% vs 37.5%). The average HRQoL scores were 0.79 (95% CI: 0.78-0.81) and 0.90 (95% CI: 0.89-0.90) for users and non-users, respectively. Moreover, EQ-VAS average values were significantly higher for non-users [80.7 (95% CI: 79.9-81.6) vs 70.27 (95% CI: 69.2-71.2)]. Controlling the sociodemographics, ST use significantly reduced the HRQoL score by an average of 0.15 points. The EQ-VAS values on average decreased by 0.04 points for ST use. CONCLUSIONS: ST use is significantly associated with the HRQoL of females in Bangladesh. Considering the higher prevalence of ST, especially among women, HRQoL hazards need to be communicated for awareness building.

Potassium augments growth, yield, nutrient content, and drought tolerance in mung bean (Vigna radiata L. Wilczek.).

Uneven rainfall and high temperature cause drought in tropical and subtropical regions which is a major challenge to cultivating summer mung bean. Potassium (K), a major essential nutrient of plants can alleviate water stress (WS) tolerance in plants. A field trial was executed under a rainout shelter with additional K fertilization including recommended K fertilizer (RKF) for relieving the harmful impact of drought in response to water use efficiency (WUE), growth, yield attributes, nutrient content, and yield of mung bean at the Regional Agricultural Research Station, BARI, Ishwardi, Pabna in two successive summer season of 2018 and 2019. Drought-tolerant genotype BMX-08010-2 (G1) and drought-susceptible cultivar BARI Mung-1 (G2) were grown by applying seven K fertilizer levels (KL) using a split-plot design with three replications, where mung bean genotypes were allotted in the main plots, and KL were assigned randomly in the sub-plots. A considerable variation was observed in the measured variables. Depending on the different applied KL and seed yield of mung bean, the water use efficiency (WUE) varied from 4.73 to 8.14 kg ha-1 mm-1. The treatment applying 125% more K with RKF (KL7) under WS gave the maximum WUE (8.14 kg ha-1 mm-1) obtaining a seed yield of 1093.60 kg ha-1. The treatment receiving only RKF under WS (KL2) provided the minimum WUE (4.73 kg ha-1 mm-1) attaining a seed yield of 825.17 kg ha-1. Results showed that various characteristics including nutrients (N, P, K, and S) content in stover and seed, total dry matter (TDM) in different growth stages, leaf area index (LAI), crop growth rate (CGR), root volume (RV), root density (RD), plant height, pod plant-1, pod length, seeds pod-1, seed weight, and seed yield in all pickings increased with increasing K levels, particularly noted with KL7. The highest grain yield (32.52%) was also obtained from KL7 compared to lower K with RKF. Overall, yield varied from 1410.37 kg ha-1 using 281 mm water (KL1; well-watered condition with RKF) to 825.17 kg ha-1 using 175 mm water (KL2). The results exhibited that the application of additional K improves the performance of all traits under WS conditions. Therefore, mung beans cultivating under WS requires additional K to diminish the negative effect of drought, and adequate use of K contributes to accomplishing sustainable productivity.

Effective Visible-Light-Driven Photocatalytic Degradation of Harmful Antibiotics Using Reduced Graphene Oxide-Zinc Sulfide-Copper Sulfide Nanocomposites as a Catalyst.

In recent decades, antibiotics have been found in aquatic environments, raising severe concerns. In this study, a unique reduced graphene oxide-zinc sulfide-copper sulfide (rGO-ZnS-CuS) nanocomposite (NC) prepared by using a straightforward surfactant-free in situ microwave method was used for antibiotic degradation via photocatalysis. The structural and morphological characteristics of the produced catalysts were characterized using various techniques, confirming the successful development of nanocomposite structures of better quality than that of the pure samples. The photocatalytic degradation of antibiotics containing ofloxacin was also investigated. The results suggest that the rGO-ZCS NC outperformed the other composites in terms of photocatalytic activity toward ofloxacin degradation. Superoxide and hydroxyl radicals were the main active species during the degradation process. According to our results, the catalytic activity of rGO-ZCS NC is much better than that of the other composites.

Receptor model-based sources and risks appraisal of potentially toxic elements in the urban soils of Bangladesh.

Rapid urbanization and industrial development have prompted potentially toxic elements (PTEs) in urban soil in Bangladesh, which is a great concern for ecological and public health matters. The present study explored the receptor-based sources, probable human health and ecological risks of PTEs (As, Cd, Pb, Cr, Ni, and Cu) in the urban soil of the Jashore district, Bangladesh. The USEPA modified method 3050B and atomic absorption spectrophotometers were used to digest and evaluate the PTEs concentration in 71 soil samples collected from eleven different land use areas, respectively. The concentration ranges of As, Cd, Pb, Cr, Ni, and Cu in the studied soils were 1.8-18.09, 0.1-3.58, 0.4-113.26, 0.9-72.09, 2.1-68.23, and 3.82-212.57 mg/kg, respectively. The contamination factor (CF), pollution load index (PLI), and enrichment factor (EF) were applied to evaluate the ecological risk posed by PTEs in soils. Soil quality evaluation indices showed that Cd was a great contributor to soil pollution. The PLI values range was 0.48-2.82, indicating base levels to continuous soil degradation. The positive matrix factorization (PMF) model showed that As (50.3 %), Cd (38.8 %), Cu (64.7 %), Pb (81.8 %) and Ni (47.2 %) were derived from industrial sources and mixed anthropogenic sources, while Cr (78.1 %) from natural sources. The highest contamination was found in the metal workshop, followed by the industrial area, and brick filed site. Soil from all land use types revealed moderate to high ecological risk after evaluating probable ecological risks, and the descending order of single metal potential ecological risk was Cd > As > Pb > Cu > Ni > Cr. Ingestion was the primary route of exposure to potentially toxic elements for both adults and children from the study area soil. The overall non-cancer risk to human health is caused by PTEs for children (HI=0.65 ± 0.1) and adults (HI=0.09 ± 0.03) under USEPA safe limit (HI>1), while the cancer risks from exclusively ingesting As through soil were 2.10E-03 and 2.74E-04 for children and adults, respectively, exceeding the USEPA acceptable standard (>1E-04).

Virtual Screening, Synthesis, and Biological Evaluation of Some Carbohydrazide Derivatives as Potential DPP-IV Inhibitors.

Dipeptidyl peptidase-4 (DPP-IV) inhibitors are known as safe and well-tolerated antidiabetic medicine. Therefore, the aim of the present work was to synthesize some carbohydrazide derivatives (1a-5d) as DPP-IV inhibitors. In addition, this work involves simulations using molecular docking, ADMET analysis, and Lipinski and Veber's guidelines. Wet-lab synthesis was used to make derivatives that met all requirements, and then FTIR, NMR, and mass spectrometry were used to confirm the structures and perform biological assays. In this context, in vitro enzymatic and in vivo antidiabetic activity evaluations were carried out. None of the molecules had broken the majority of the drug-likeness rules. Furthermore, these molecules were put through additional screening using molecular docking. In molecular docking experiments (PDB ID: 2P8S), many molecules displayed more potent interactions than native ligands, exhibiting more hydrogen bonds, especially those with chloro- or fluoro substitutions. Our findings indicated that compounds 5b and 4c have IC50 values of 28.13 and 34.94 µM, respectively, under in vitro enzymatic assays. On the 21st day of administration to animals, compound 5b exhibited a significant reduction in serum blood glucose level (157.33 ± 5.75 mg/dL) compared with the diabetic control (Sitagliptin), which showed 280.00 ± 13.29 mg/dL. The antihyperglycemic activity showed that the synthesized compounds have good hypoglycemic potential in fasting blood glucose in the type 2 diabetes animal model (T2DM). Taken all together, our findings indicate that the synthesized compounds exhibit excellent hypoglycemic potential and could be used as leads in developing novel antidiabetic agents.

Factors Influencing Rural End-Users' Acceptance of e-Health in Developing Countries: A study on Portable Health Clinic in Bangladesh.

BACKGROUND: Existing studies regarding e-health are mostly focused on information technology design and implementation, system architecture and infrastructure, and its importance in public health with ancillaries and barriers to mass adoption. However, not enough studies have been conducted to assess the end-users' reaction and acceptance behavior toward e-health, especially from the perspective of rural communities in developing countries. OBJECTIVE: The objective of this study is to explore the factors that influence rural end users' acceptance of e-health in Bangladesh. METHODS: Data were collected between June and July 2016 through a field survey with structured questionnaire form 292 randomly selected rural respondents from Bheramara subdistrict, Bangladesh. Technology Acceptance Model was adopted as the research framework. Logistic regression analysis was performed to test the theoretical model. RESULTS: The study found social reference as the most significantly influential variable (Coef. = 2.28, odds ratio [OR] = 9.73, p < 0.01) followed by advertisement (Coef. = 1.94, OR = 6.94, p < 0.01); attitude toward the system (Coef. = 1.52, OR = 4.56, p < 0.01); access to cellphone (Coef. = 1.37, OR = 3.92, p < 0.05), and perceived system effectiveness (Coef. = 0.74, OR = 2.10, p < 0.01). Among demographic variables, age, gender, and education were found significant while we did not find any significant impact of respondents' monthly family expenditure on their e-health acceptance behavior. The model explains 54.70% deviance (R2 = 0.5470) in the response variable with its constructs. The "Hosmer-Lemeshow" goodness-of-fit score (0.539) is also above the standard threshold (0.05), which indicates that the data fit well with the model. CONCLUSION: The study provides guidelines for the successful adoption of e-health among rural communities in developing countries. This also creates an opportunity for e-health technology developers and service providers to have a better understanding of their end users.

Factors Affecting Rural Patients' Primary Compliance with e-Prescription: A Developing Country Perspective.

Background:The electronic prescription system has emerged to reduce the ambiguity and misunderstanding associated with handwritten prescriptions. The opportunities and challenges of e-prescription system, its impact on reducing medication error, and improving patient's safety have been widely studied. However, not enough studies were conducted to explore and quantify the factors that affect rural patients' compliance with e-prescription, especially from the perspective of Asian developing countries where most of the world's population resides.Objective:The objective of this study is to explore and assess the factors that affect rural patients' primary compliance with e-prescription in Bangladesh.Methods:Data were collected from 95 randomly selected rural patients who received e-prescription through a field survey with a structured questionnaire from Bheramara subdistrict, Bangladesh, during June and July 2016. Logistic regression analysis was performed to test the research hypotheses.Results:The study found patients' gender as the most significantly influential factor (regression coefficient [Coef.] = 2.02, odds ratio [OR] = 7.51, p < 0.05) followed by visiting frequency (Coef. = 0.99, OR = 2.70, p < 0.05); education (Coef. = 0.92, OR = 2.51, p < 0.05); and distance to healthcare facility (Coef. = 0.82, OR = 2.26, p < 0.01). However, patients' age, monthly family expenditure, and use of cell phone were found insignificant. The model explains 59.40% deviance (R2 = 0.5940) in the response variable with its constructs. And the "Hosmer-Lemeshow" goodness-of-fit score (0.99) is also above the standard threshold (0.05), which indicates the data fit well with the model.Conclusions:The findings of this study are expected to be helpful for e-health service providers to gain a better understanding of the factors that influence their patients to comply with e-prescriptions.

Antagonistic activity of antibiotic producing Streptomyces sp. against fish and human pathogenic bacteria

In this study, attempts were made to isolate Streptomyces sp. from soil samples of two different regions of Bangladesh and evaluate their antagonistic activity against fish and human pathogenic bacteria. A total of 10 isolates were identified as Streptomyces sp. based on several morphological, physiological and biochemical tests. Cross streak method was used to observe the antagonistic activity of the Streptomyces sp. isolates against different fish pathogens belonging to the genus Aeromonas, Pseudomonas and Edwardsiella and human clinical isolates belonging to the genus Klebsiella, Salmonella and Streptococcus. Seven Streptomyces sp. isolates showed antagonism against both fish and human pathogenic bacteria. Four isolates viz., N24, N26, N28 and N47 showed broad spectrum of antagonistic activity (80-100%) against all genera of fish and human pathogenic bacteria. The isolate N49 exhibited highest spectrum of antagonism against all fish pathogens (90-100%) but comparatively lower degree of antagonism against human pathogens (50-60%). Rest of the two isolates (N21 and N23) showed variability in their antagonism. Results showed that broad spectrum antibiotic(s) could be developed from the isolates N24, N26, N28 and N47against several human and fish pathogens. The isolate N49 could be a potential source of antibiotic, especially for fish pathogenic bacteria.