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Chem Commun (Camb) ; 60(43): 5634-5637, 2024 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-38716634

RESUMO

Rh-catalyzed three-component C(sp3)/C(sp2)-H activation has been achieved through a two-directing group strategy. This protocol provides a convenient and efficient pathway for the construction of diverse 8-alkyl quinoline derivatives in one-pot. Furthermore, mechanistic studies revealed that the first C-H amidation was significantly faster than the sequential C-H alkylation.

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