1.
Chem Commun (Camb)
; 58(57): 7912-7915, 2022 Jul 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35726903
RESUMO
Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using in vitro assays through to preclinical validation.
Assuntos
Anticorpos Biespecíficos , Nanoestruturas , Neoplasias , Humanos , Nanomedicina , Neoplasias/tratamento farmacológico , Polímeros
2.
Chem Commun (Camb)
; 54(82): 11538-11541, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30182121
RESUMO
We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.