RESUMO
Clinical trials have reported that a four-oil intravenous lipid emulsion (SMOFlipid) play a positive role in immune function, but showed inconsistent outcomes compared to other lipid emulsions. A systematic review and meta-analysis was conducted to evaluate the effect of SMOFlipid on liver function, triglycerides (TG), inflammatory markers, and clinical outcomes in hospitalized adults after short-term use compared to others. A search of the PubMed, Medline, Embase, China National Knowledge Infrastructure, and Wanfang databases was performed to identify the included randomized controlled trials. Trials with adults who were administrated a short-term course of SMOFlipid were included. A meta-analysis on liver function markers, TG, inflammatory markers, and clinical outcomes was conducted. A total of 18 randomized controlled trials with 1188 patients were included. Compared to other lipid emulsions, SMOFlipid was associated with a significant reduction in ALT, AST, γ-glutamyltransferase, total bilirubin, TG, C-reactive protein and length of hospital stay. No effect on serum interleukin-6 levels or adverse events were observed. For adult patients, our meta-analysis indicated that SMOFlipid may be beneficial to the liver and prone to prevent hyperlipidemia. The SMOFlipid also shortened length of hospital stay.
Assuntos
Emulsões Gordurosas Intravenosas/farmacologia , Ácidos Graxos Ômega-3/farmacologia , Óleos de Peixe/farmacologia , Tempo de Internação , Fígado/efeitos dos fármacos , Azeite de Oliva/farmacologia , Nutrição Parenteral , Óleo de Soja/farmacologia , Triglicerídeos/sangue , Adulto , Emulsões Gordurosas Intravenosas/química , Emulsões Gordurosas Intravenosas/metabolismo , Emulsões Gordurosas Intravenosas/uso terapêutico , Ácidos Graxos Ômega-3/sangue , Ácidos Graxos Ômega-3/uso terapêutico , Óleos de Peixe/sangue , Óleos de Peixe/uso terapêutico , Humanos , Hiperlipidemias/prevenção & controle , Inflamação/prevenção & controle , Fígado/metabolismo , Azeite de Oliva/uso terapêutico , Óleos de Plantas/metabolismo , Óleos de Plantas/farmacologia , Óleos de Plantas/uso terapêutico , Óleo de Soja/sangue , Óleo de Soja/uso terapêutico , Triglicerídeos/farmacologia , Triglicerídeos/uso terapêuticoRESUMO
Surgery, radiotherapy, and chemotherapy are the main treatments for tongue cancer, but the nutritional status of patients is not considered. Nutritional treatment is often not standard or by experience. This article reports a patient with tongue cancer who underwent preoperative chemotherapy and postoperative nutrition treatment. The entire process of individualized and sequential nutrition therapy was adopted, and the nutritional status of the patient was significantly improved. This paper describes the methods of nutrition therapy and evaluation and discusses the treatment process and key points in combination with relevant literature.