Rh(iii)-Catalyzed ortho-C-H alkynylation of N-phenoxyacetamides with hypervalent iodine-alkyne reagents at room temperature.

A Rh(iii)-catalyzed C-H alkynylation of substituted N-phenoxyacetamides has been developed with the aid of hypervalent iodine-alkyne reagents. Complementary to the Sonogashira coupling reaction, this protocol provides an efficient and straightforward method to access aryl alkynes at room temperature. The multifunctional directing group is preserved which can be further employed for ortho-directed functionalizations to obtain additional new complex products.

A novel H2O2 biosensor based on three-dimensional micro/nano-biointerfaces.

To detect hydrogen peroxide (H2O2) that is released in situ by cells is a challenge because of its high activity and short life time. Here, a new type of H2O2 biosensor was reported based on three-dimensional (3D) micro/nano-biointerfaces as an amicable platform to promote cell adhesion, and which can directly grow living cells on manganese dioxide (MnO2) immobilized onto a novel hollow horn-like morphology polypyrrole (hPPy) film. The composite MnO2/hPPy array films were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and elemental mapping. Further, the results of a cell adhesion test indicated that the as-obtained 3D micro/nano-array films had good cell adhesion. This proposed sensing platform provided high electroactivity and excellent electron transport with a lower detection limit, a higher sensitivity and a short diffusion distance to reaction sites by electrochemical study. The new design strategy we proposed can expand the bioapplication of 3D micro/nano-biointerfaces that can guide cell fate and electrochemical detection in cell biology.