RESUMO
HLA-DPB1*05:01:20 differs from HLA-DPB1*05:01:01:01 by one nucleotide in exon 3.
Assuntos
Alelos , Povo Asiático , Sequência de Bases , Éxons , Cadeias beta de HLA-DP , Teste de Histocompatibilidade , Análise de Sequência de DNA , Humanos , Cadeias beta de HLA-DP/genética , Povo Asiático/genética , Análise de Sequência de DNA/métodos , Doadores de Tecidos , Alinhamento de Sequência , Códon , População do Leste AsiáticoRESUMO
HLA-C*03:652 differs from the HLA-C*03:04:01:01 by one nucleotide in exon 3.
Assuntos
Alelos , Povo Asiático , Sequência de Bases , Éxons , Antígenos HLA-C , Teste de Histocompatibilidade , Análise de Sequência de DNA , Humanos , Povo Asiático/genética , Códon , População do Leste Asiático , Antígenos HLA-C/genética , Alinhamento de Sequência , Análise de Sequência de DNA/métodosRESUMO
HLA-B*46:01:42 differs from HLA-B*46:01:01:01 by one nucleotide in exon 5.
Assuntos
Genes MHC Classe I , Nucleotídeos , Humanos , Alelos , Antígenos HLA-B/genética , China , Análise de Sequência de DNARESUMO
HLA-C*08:273 differs from HLA-C*08:01:01:01 by one nucleotide in exon 2.
Assuntos
Genes MHC Classe I , Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , Nucleotídeos , China , Análise de Sequência de DNARESUMO
HLA-B*38:103N differs from HLA-B*38:02:01:01 by one nucleotide in exon 3.
Assuntos
Antígenos HLA-B , Nucleotídeos , Humanos , Alelos , Análise de Sequência de DNA , Antígenos HLA-B/genética , ChinaRESUMO
HLA-B*48:01:13 differs from HLA-B*48:01:01:01 by one nucleotide in exon 5.
Assuntos
Antígenos HLA-B , Nucleotídeos , Humanos , Alelos , Análise de Sequência de DNA , Antígenos HLA-B/genética , ChinaRESUMO
HLA-A*11:448 differs from HLA-A*11:01:01:01 by one nucleotide in exon 5.
Assuntos
Antígenos HLA-A , Nucleotídeos , Humanos , Alelos , Análise de Sequência de DNA , Antígenos HLA-A/genética , ChinaRESUMO
HLA-B*27:267 differs from HLA-B*27:04:01 by one nucleotide in exon 2.
Assuntos
População do Leste Asiático , Antígenos HLA-B , Humanos , Alelos , Análise de Sequência de DNA , Antígenos HLA-B/genética , NucleotídeosRESUMO
The function of natural killer (NK) cells has previously been implicated in hematopoietic-related diseases. Killer immunoglobulin-like receptors (KIR) play an important role in NK cells after hematopoietic stem cell transplantation. To explore the immunogenetic predisposition of hematological-related diseases, herein, a multi-center retrospective study in China was conducted, analyzing and comparing 2519 patients with hematopathy (mainly, acute lymphoblastic leukemia, acute myeloid leukemia, aplastic anemia, and myelodysplastic syndrome) to 18,108 individuals without known pathology. Genotyping was performed by polymerase chain reaction with specific sequence primers (PCR-SSP). As a result, we discovered four genes including KIR2DL5 (OR: 0.74, 95% CI 0.59-0.93; Pc = 0.0405), 2DS1 (OR: 0.74, 95% CI 0.59-0.93; Pc = 0.0405), 2DS3 (OR: 0.58, 95% CI 0.41-0.81; Pc = 0.0180), and 3DS1 (OR: 0.74, 95% CI 0.58-0.94; Pc = 0.0405) to be protective factors that significantly reduce the risk of aplastic anemia. Our findings offer new approaches to immunotherapy for hematological-related diseases. As these therapies mature, they are promising to be used alone or in combination with current treatments to help to make blood disorders a manageable disease.
Assuntos
Anemia Aplástica , Doenças Hematológicas , Humanos , Estudos Retrospectivos , Anemia Aplástica/genética , População do Leste Asiático , Receptores KIR/genética , Genótipo , Doenças Hematológicas/genética , Frequência do GeneRESUMO
Due to the high similarity in their requirements for space and food, close bacterial relatives may be each other's strongest competitors. Close bacterial relatives often form visible boundaries to separate their swarming colonies, a phenomenon termed colony-merger incompatibility. While bacterial species are known to have many incompatible strains, it is largely unclear which traits lead to multiple incompatibilities and the interactions between multiple incompatible siblings. To investigate the competitive interactions of closely related incompatible strains, we mutated Myxococcus xanthus DK1622, a predatory bacterium with complex social behavior. From 3392 random transposon mutations, we obtained 11 self-identification (SI) deficient mutants that formed unmerged colony boundaries with the ancestral strain. The mutations were at nine loci with unknown functions and formed nine independent SI mutants. Compared with their ancestral strain, most of the SI mutants showed reduced growth, swarming and development abilities, but some remained unchanged from their monocultures. When pairwise mixed with their ancestral strain for co-cultivation, these mutants exhibited improved, reduced or unchanged competitive abilities compared with the ancestral strain. The sporulation efficiencies were affected by the DK1622 partner, ranging from almost complete inhibition to 360% stimulation. The differences in competitive growth between the SI mutants and DK1622 were highly correlated with the differences in their sporulation efficiencies. However, the competitive efficiencies of the mutants in mixture were inconsistent with their growth or sporulation abilities in monocultures. We propose that the colony-merger incompatibility in M. xanthus is associated with multiple independent genetic loci, and the incompatible strains hold competitive interaction abilities, which probably determine the complex relationships between multiple incompatible M. xanthus strains and their co-existence strategies.