Interface stress transfer model and modulus parameter equivalence method for composite materials embedded with tensile pre-strain shape memory alloy fibers.

The constitutive model and modulus parameter equivalence of shape memory alloy composites (SMAC) serve as the foundation for the structural dynamic modeling of composite materials, which has a direct impact on the dynamic characteristics and modeling accuracy of SMAC. This article proposes a homogenization method for SMA composites considering interfacial phases, models the interface stress transfer of three-phase cylinders physically, and derives the axial and shear stresses of SMA fiber phase, interfacial phase, and matrix phase mathematically. The homogenization method and stress expression were then used to determine the macroscopic effective modulus of SMAC as well as the stress characteristics of the fiber phase and interface phase of SMA. The findings demonstrate the significance of volume fraction and tensile pre-strain in stress transfer between the fiber phase and interface phase at high temperatures. The maximum axial stress in the fiber phase is 705.05 MPa when the SMA is fully austenitic and the pre-strain increases to 5%. At 10% volume fraction of SMA, the fiber phase's maximum axial stress can reach 1000 MPa. Ultimately, an experimental verification of the theoretical calculation method's accuracy for the effective modulus of SMAC lays the groundwork for the dynamic modeling of SMAC structures.

TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception.

Efforts on developing transient receptor potential vanilloid 1 (TRPV1) drugs for pain management have been hampered by deleterious hypo- or hyperthermia caused by TRPV1 agonists/antagonists. Here, we compared the effects of four antagonists on TRPV1 polymodal gating and core body temperature (CBT) in Trpv1+/+, Trpv1-/-, and Trpv1T634A/T634A. Neither the effect on proton gating nor drug administration route, hair coverage, CBT rhythmic fluctuations, or inflammation had any influence on the differential actions of TRPV1 drugs on CBT. We identified the S4-S5 linker region exposed to the vanilloid pocket of TRPV1 to be critical for hyperthermia associated with certain TRPV1 antagonists. PSFL2874, a TRPV1 antagonist we discovered, is effective against inflammatory pain but devoid of binding to the S4-S5 linker and inducing CBT changes. These findings implicate that biased allosteric mechanisms exist for TRPV1 coupling to nociception and CBT regulation, opening avenues for the development of non-opioid analgesics without affecting CBT.

Solvent-free synthesis of foam board-like CoSe2 alloy to selectively generate singlet oxygen via peroxymonosulfate activation for sulfadiazine degradation.

Singlet oxygen (1O2) is a highly effective reactive species in selectively oxidizing organic pollutants. However, it is still challenging to rationally design robust catalysts for the selective generation of 1O2. Herein, the coordination and engineering architecture of the foam board-like CoSe2 alloy were facilely constructed through a green solvent-free method and displayed almost 100% 1O2 production selectivity. The CoSe2 alloy showed excellent catalytic ability for the efficient and fast removal of organic pollutants via peroxymonosulfate (PMS) activation compared with previously reported cobalt-based catalysts. The CoSe2/PMS system exhibited strong resistance for a broad pH range (3.0-11.0) and various coexisting inorganic ions owing to the advantage of the strong bonding of Co-Se in CoSe2 alloy. Mechanism studies revealed that 1O2 was the only reactive oxygen species in the CoSe2/PMS system. Theoretical calculations demonstrated that Co was the dominant adsorption site for PMS in CoSe2, and the production pathway of 1O2 was PMS* â†’ *OH → *O → 1O2. In addition, it was proved that *OH and *O served as the rate-determining steps for the formation of 1O2 by PMS activation on CoSe2 alloy. These findings provide a rational strategy for preparing a series of low-cost transition metal-based alloy catalysts for PMS activation to achieve high-efficiency 1O2 production in the elimination of organic pollutants.

Loop Closure Detection Method Based on Similarity Differences between Image Blocks.

Variations with respect to perspective, lighting, weather, and interference from dynamic objects may all have an impact on the accuracy of the entire system during autonomous positioning and during the navigation of mobile visual simultaneous localization and mapping (SLAM) robots. As it is an essential element of visual SLAM systems, loop closure detection plays a vital role in eradicating front-end-induced accumulated errors and guaranteeing the map's general consistency. Presently, deep-learning-based loop closure detection techniques place more emphasis on enhancing the robustness of image descriptors while neglecting similarity calculations or the connections within the internal regions of the image. In response to this issue, this article proposes a loop closure detection method based on similarity differences between image blocks. Firstly, image descriptors are extracted using a lightweight convolutional neural network (CNN) model with effective loop closure detection. Subsequently, the image pairs with the greatest degree of similarity are evenly divided into blocks, and the level of similarity among the blocks is used to recalculate the degree of the overall similarity of the image pairs. The block similarity calculation module can effectively reduce the similarity of incorrect loop closure image pairs, which makes it easier to identify the correct loopback. Finally, the approach proposed in this article is compared with loop closure detection methods based on four distinct CNN models with a recall rate of 100% accuracy; said approach performs significantly superiorly. The application of the block similarity calculation module proposed in this article to the aforementioned four CNN models can increase the recall rate's accuracy to 100%; this proves that the proposed method can successfully improve the loop closure detection effect, and the similarity calculation module in the algorithm has a certain degree of universality.

Sound Quality Performance of Orthogonal Antisymmetric Composite Laminates Embedded with SMA Wires.

Orthogonal antisymmetric composite laminates embedded with shape memory alloys (SMAs) wires have the potential to improve the sound quality of vibro-acoustics by taking advantage of the special superelasticity, temperature phase transition, and pre-strain characteristics of SMAs. In this research, space discretion and mode decoupling were employed to establish a vibro-acoustic sound quality model of SMA composite laminates. The association between the structural material parameters of SMA composite laminates and the sound quality index is then approached through methodologies. Numerical analysis was implemented to discuss the effects of SMA tensile pre-strain, SMA volume fraction, and the ratio of resin-to-graphite in the matrix on the vibro-acoustic sound quality of SMA composite laminates within a temperature environment. Subsequently, the sound quality test for SMA composite laminates is thus completed. The theoretically predicted value appears to agree well with the experimental outcomes, which validates the accuracy and applicability of the dynamic modeling theory and method for the sound quality of SMA composite laminates. The results indicate that attempting to alter the SMA tensile pre-strain, SMA volume fraction, and matrix material ratio can be used to modify loudness, sharpness, and roughness, which provides new ideas and a theoretical foundation for the design of composite laminates with decent sound quality.

Research on the Weighting Values of Community Aging-Friendly Construction Indexes With Different Expert Groups.

The construction of weight values for the indicators of community aging-friendly construction is helpful to guide the formulation of strategies for allocating elderly resources in community aging-friendly constructions, and to reflect the shortcomings of community aging-friendly constructions and propose improvement strategies when evaluating the effectiveness of the existing community aging-friendly constructions. The paper uses the Fuzzy Analytic Hierarchy Process (FAHP) to calculate the weighting values of each indicator, consulting the government, industry, and academic experts. The research results show that the weighting-value order is "public environment (W = 0.364)," "health care (W = 0.342)," "humanistic care (W = 0.204)" and "social economy (W = 0.090)." Accordingly, the article proposes specific suggestions to improve the effectiveness of community aging-friendly constructions, including the need to find consensus among all parties involved in the aging industry, the need to focus on improving the public environment of the community, and the need to improve the socio-economic policies as soon as possible.

Fast and Precise Temperature Control for Axon Stretch Growth Bioreactor Based on Fuzzy PID Control.

A suitable environment is essential for successful long-term cell culturing in vitro. Too high or too low temperature will affect the growth of cells, so we need to maintain the constant temperature of the cell culture environment. Usually, cells are cultured in a cell incubator, and the constant temperature is provided by the cell incubator. Recently, we have developed a multi-channel axon stretch growth bioreactor for rapid acquisition of autologous nerve tissue. Since the motor and controller are placed in the incubator for a long time, the service life of the equipment will be shortened or even damaged due to high humidity and weak acid environment. In order to enable the axon stretch growth bioreactor to culture cells independently, we designed a constant temperature control system for the device. Firstly, the simulation results show that the fuzzy PID control reduces the overshoot and improves the traditional PID control with large overshoot and low control precision. Then, the two control algorithms were applied to the multi-channel axon stretch growth bioreactor by STM32F4 microcontroller. The experimental data show that the fuzzy PID control algorithm has good control effect and can meet the requirement of constant temperature of cell growth. Finally, nerve cells derived from human pluripotent stem cells were successfully cultured in a cell culture amplification chamber under a constant temperature environment provided by a fuzzy PID controller, and well-developed axons could be seen. In the future, we may transplant stretch growth axons into living organisms to repair nerve damage.

A Cylindrical Near-Field Acoustical Holography Method Based on Cylindrical Translation Window Expansion and an Autoencoder Stacked with 3D-CNN Layers.

The performance of near-field acoustic holography (NAH) with a sparse sampling rate will be affected by spatial aliasing or inverse ill-posed equations. Through a 3D convolution neural network (CNN) and stacked autoencoder framework (CSA), the data-driven CSA-NAH method can solve this problem by utilizing the information from data in each dimension. In this paper, the cylindrical translation window (CTW) is introduced to truncate and roll out the cylindrical image to compensate for the loss of circumferential features at the truncation edge. Combined with the CSA-NAH method, a cylindrical NAH method based on stacked 3D-CNN layers (CS3C) for sparse sampling is proposed, and its feasibility is verified numerically. In addition, the planar NAH method based on the Paulis-Gerchberg extrapolation interpolation algorithm (PGa) is introduced into the cylindrical coordinate system, and compared with the proposed method. The results show that, under the same conditions, the reconstruction error rate of the CS3C-NAH method is reduced by nearly 50%, and the effect is significant.

Research on the establishment of evaluation index system of the aging construction of the community.

Introduction: Constructing the evaluation index system for the community's aging-friendly construction can provide a decision-making basis for the overall investment and priority satisfaction strategy for the community's aging-friendly construction. Methods: Through questionnaire survey and statistical analysis, this paper evaluates and analyzes the satisfaction level of various indicators of the community's aging-friendly construction. Results: The results show that the community's humanistic care, public environment, and socio-economic criteria are significantly linearly linked to the overall construction satisfaction level. There are significant differences in the general satisfaction level of older adults in the variables of "age, educational background, residence duration, residence personnel, number of children, and marital status". Discussion: To this end, the article concludes with specific recommendations that improving older-adult care services for older adults with low age and high education, helping older adults in the community to familiarize themselves with the community environment as soon as possible, cultivating the professional abilities of community service personnel, reflecting the warmth of the community for older-adult care and improving social security capabilities are the core content of the future community building for aging.

Sound Transmission Loss of Metamaterial Honeycomb Core Sandwich Plate Elastically Connected with Periodic Subwavelength Arrays of Shunted Piezoelectric Patches.

Honeycomb core sandwich plates are widely used as a lightweight, high-strength sound insulation material. However, they do not perform well in specific frequency bands. Acoustic metamaterials can break the law of mass in specific frequency bands and have high sound transmission loss (STL); however, the resonance frequency is difficult to regulate. To solve this problem, this paper first proposes an infinitely large metamaterial honeycomb core sandwich plate, which can generate newly tuned piezoelectric resonance frequencies, and we study its STL. The structure has piezoelectric patches arranged in sub-wavelength arrays with inductance shunting circuits that are elastically connected to both sides of the honeycomb core sandwich plate. The effective dynamic mass density and effective dynamic bending stiffness of the metamaterial plates were obtained using the effective medium (EM) method. A theoretical model for the numerical calculation of oblique STL and diffuse-field STL was established by the structural bending wave method. The finite element simulation method was used to verify that the metamaterial plates can generate three peaks at 1147 Hz, 1481 Hz and 1849 Hz in oblique or diffuse-field STL curves, which reached 57 dB, 86 dB and 63 dB, respectively, and are significantly better than the plate rigidly connected with piezoelectric sheets and the bare plate with the same mass. In order to better understand the characteristics of STL, the explicit functions of the resonance frequencies were derived. Key influencing factors were analyzed, and the regulation law of new piezoelectric resonance frequencies was clarified.

Embedded growth of colorful CsPbX3(X = Cl, Br, I) nanocrystals in metal-organic frameworks at Room Temperature.

Herein, we develop a novel strategy for preparing all-inorganic cesium lead halide (CsPbX3, X = Cl, Br, I) perovskite nanocrystals (NCs)@Zn-based metal-organic framework (MOF) composites through interfacial synthesis. The successful embedding of fluorescent perovskite NCs in Zn-MOFs is due to thein situconfined growth, which is attributed to the re-nucleation of water-triggered phase transformation from Cs4PbBr6to CsPbBr3. The controllable synthesis of mixed-halide based composites with various emission wavelength can be achieved by adding the desired amount of halide (Cl or I) salts in the re-nucleation process. More importantly, the anion exchange reaction is inhibited among various composites with different halogen atoms by being trapped in MOFs. Besides, a white light-emitting diode (WLED) is produced using a blue LED chip with the green-emitting and red-emitting composites, which has a color coordinate of (0.3291, 0.3272) and a wide color gamut. This work provides a novel route to achieving perovskite NCs growth in MOFs, which also can be extended to the other NCs embedded in frames as well.

Sound Radiation of Orthogonal Antisymmetric Composite Laminates Embedded with Pre-Strained SMA Wires in Thermal Environment.

The interest of this article lies in the sound radiation of shape memory alloy (SMA) composite laminates. Different from the traditional method of avoiding resonance sound radiation of composite laminates by means of structural parameter design, this paper explores the potential of adjusting the modal peak of the resonant acoustic radiation by using material characteristics of shape memory alloys (SMA), and provides a new idea for avoiding resonance sound radiation of composite laminates. For composite laminates embedded with pre-strained SMA, an innovation of vibration-acoustic modeling of SMA composite laminates considering pre-stain of SMA and thermal expansion force of graphite-epoxy resin is proposed. Based on the classical thin plate theory and Hamilton principle, the structural dynamic governing equation and the frequency equation of the laminates subjected to thermal environment are derived. The vibration sound radiation of composite laminates is calculated with Rayleigh integral. Effects of ambient temperature, pre-strain, SMA volume fraction, substrate ratio, and geometrical parameters on the sound radiation were analyzed. New laws of SMA material and pre-strain characteristics on sound radiation of composite laminates under temperature environment are revealed, which have theoretical and engineering functional significance for vibration and sound radiation control of SMA composite laminates.

Muricauda oceani sp. nov., isolated from the East Pacific Ocean.

A Gram-stain-negative bacterium, designated strain 501str8T, was isolated from a sediment sample collected from the East Pacific Ocean. 16S rRNA gene sequence analysis revealed that strain 501str8T belonged to the genus Muricauda, with closely related type strains Muricauda aquimarina SW-63T (98.5 %), Muricauda lutimaris SMK-108T (98.3 %) and Muricauda ruestringensis B1T (97.9 %). Up-to-date bacterial core gene set analysis revealed that strain 501str8T represented one independent lineage with M. aquimarina SW-63T. The average nucleotide identity values of strain 501str8T with M. aquimarina SW-63T and M. lutimaris SMK-108T were 80.2 and 81.3 %, respectively. In silico DNA-DNA hybridization values between strain 501str8T and M. aquimarina SW-63T and M. lutimaris SMK-108T were 22.8 and 32.9 %, respectively. The predominant isoprenoid quinone was menaquinone-6, and iso-C15 : 0, iso-C17 : 0 3-OH and iso-C15 : 1 G were the dominant cellular fatty acids. The G+C content of the genomic DNA was 42.8 mol%. Differential phylogenetic distinctiveness and chemotaxonomic differences, together with the phenotypic properties observed in this study, revealed that strain 501str8T could be differentiated from closely related species. Therefore, we propose that strain 501str8T represents a novel species of the genus Muricauda, for which the name Muricauda oceani sp. nov. is suggested. The type strain is 501str8T (=JCM 33902T=MCCC 1K04567T).

Jiella pacifica sp. nov., isolated from the West Pacific Ocean.

A Gram-stain-negative bacterium, designated strain 40Bstr34T, isolated from a sediment sample from the West Pacific Ocean, was taxonomically characterized by using a polyphasic approach. The strain was phylogenetically close to Jiella aquimaris LZB041T and Jiella endophytica CBS5Q-3T, with 16S rRNA gene sequence similarities of 98.5 and 97.1 %, respectively. The genome of strain 40Bstr34T featured a G+C content of 65.7 % for a 5.8 Mb chromosome. Up-to-date bacterial core gene set analysis revealed that strain 40Bstr34T represents one independent lineage with J.aquimaris LZB041T. In silico DNA-DNA hybridization values between strain 40Bstr34T and its phylogenetic neighbours ranged from 30.3-34.2 %, below the cutoff of 70 %. In addition, the corresponding average nucleotide identity values were between 81.8-83.7 %, which are lower than 95 % threshold. The predominant cellular fatty acids of strain 40Bstr34T were summed feature 8 (C18 : 1 ω6c and/or C18 : 1 ω7c), cyclo-C19 : 0 ω8c and iso-C17 : 0 3-OH, and ubiquinone-10 as the predominant respiratory quinone. The major polar lipids included phosphatidylethanolamine, phosphatidylmonomethylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, phosphatidylcholine, two unidentified aminolipids and two unidentified lipids. Based on the results of phenotypic, chemotaxonomic and genetic analyses, strain 40Bstr34T is identified as representing a novel species of the genus Jiella for which the name Jiella pacifica sp. nov. is proposed. The type strain is 40Bstr34T (=JCM 33903T=MCCC 1K04569T).

Modal Performance of Two-Fiber Orthogonal Gradient Composite Laminates Embedded with SMA.

A gradient composite laminate that was composed of two­phase fibers, a shape memory alloy (SMA), and graphite was prepared to investigate modal performance and improve vibration behavior. The stress­strain relation of the single­layer composite plates was derived from Kirchhoff thin plate theory and the material constitutive of the SMA. A gradient distribution model and the eigenvalue equations of gradient composite laminates were developed. The influence of the fiber component content gradient distribution, pre­strain, the two­phase fiber volume fraction, and geometric parameters on the modal performance was analyzed. This study provides a method to avoid the structural resonance of composite laminates that are embedded with an SMA through the gradient distribution of two­phase fiber content that leads to the interaction of the material properties.

Devosia indica sp. nov., isolated from surface seawater in the Indian Ocean.

A Gram-stain-negative bacterium, designated IO390501T, was isolated from a sea water sample from the Indian Ocean and taxonomically characterized using a polyphasic approach. The strain is phylogenetically close to 'Devosia lucknowensis' L15 and Devosia chinhatensis IPL18T, with 16S rRNA gene sequence similarity of 97.7 and 97.4 %, respectively. The genome of IO390501T has a DNA G+C content of 61.9 mol% for the 3.9 Mb chromosome. Genome-based phylogenetic trees indicated that IO390501T clusters as an independent lineage with 'D. lucknowensis' L15. Genomic relatedness of in silico DNA-DNA hybridization between IO390501T and phylogenetic neighbours ranged from 18.8 to 21.5 %, below the cutoff of 70 %, and corresponding average nucleotide identity values were between 71.4 and 79.0 %, lower than the 95.0 % threshold. The predominant cellular fatty acids of IO390501T are summed feature 8 (C18 : 1ω7c/C18  : 1ω6c) and C16  :  0. IO390501T contains ubiquinone-10 as the sole respiratory quinone, and phosphatidylglycerol and glycolipids as the major polar lipids. On the basis of the results of phenotypic, chemotaxonomic and genetic analyses, strain IO390501T represents a novel species of the genus Devosia for which the name Devosia indica sp. nov. is proposed. The type strain is IO390501T.

Paracoccus indicus sp. nov., isolated from surface seawater in the Indian Ocean.

Strain IO390502T, isolated from surface seawater in the Indian Ocean, was characterised using a polyphasic taxonomy approach. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain IO390502T belongs to the genus Paracoccus and is closely related to Paracoccus seriniphilus DSM 14827T (97.6%), followed by P. zeaxanthinifaciens JCM 21774T (97.5%), P. homiensis DSM 17862T (97.3%), P. marcusii DSM 11574T (97.2%), P. haeundaensis BC 74171T (97.0%) and P. carotinifaciens E-396T (97.0%). Cells are Gram-negative, aerobic, poly-ß-hydroxybutyrate-accumulating, motile, rod-shaped, and forms creamy-white colonies. Optimal growth occurred at 25-30 °C, pH 5-8, and in the presence of 3-8% NaCl. The genome of strain IO390502T has a G+C content of 64.9 mol% and a 3.5 Mb chromosome. The in silico DNA-DNA hybridisation and average nucleotide identity values between strain IO390502T and the three closely related taxa, P. seriniphilus DSM 14827T, P. zeaxanthinifaciens JCM 21774T and P. homiensis DSM 17862T, are 19.6%, 21.9% and 20.6%, and 76.0%, 79.9% and 77.8%, respectively. Phosphatidylglycerol is the major lipid present, ubiquinone-10 (Q-10) is the sole isoprenoid quinone, and the major cellular fatty acid is C18:1ω7c. Based on data from phenotypic tests and genotypic differences between strain IO390502T and its close phylogenetic relatives, strain IO390502T represents a new species belonging to the genus Paracoccus, for which the name Paracoccus indicus sp. nov. is proposed. The type strain is IO390502T (= JCM 32637T = CCTCC AB 2018071T).

Muricauda sediminis sp. nov., isolated from western Pacific Ocean sediment.

A Gram-stain-negative bacterium, designated strain 40Bstr401T, was isolated from a sediment sample collected from the western Pacific Ocean. Analysis of its 16S rRNA gene sequence revealed that strain 40Bstr401T belongs to the genus Muricauda and is closely related to type strains Muricauda antarctica Ar-22T (98.2 %), Muricauda taeanensis 105T (98.2 %) and Muricauda beolgyonensis BB-My12T (97.4 %). The average nucleotide identity values for 40Bstr401T with M. antarctica Ar-22T and M. taeanensis 105T are 79.3 % and 78.8 %, respectively. The in silico DNA-DNA hybridization values between strain 40Bstr401T and M. antarctica Ar-22T and M. taeanensis 105T are 26.7 and 26.6 %, respectively. The major isoprenoid quinone of 40Bstr401T is MK-6, and iso-C17 : 0 3-OH and iso-C15 : 0 are the dominant cellular fatty acids. The major polar lipids are phosphatidylethanolamine, four unidentified amino lipids and two unidentified lipids. The G+C content of the genomic DNA is 42.9 mol%. Its phylogenetic distinctiveness and chemotaxonomic differences, together with the phenotypic properties observed in this study, indicate that strain 40Bstr401T can be differentiated from closely related species. Therefore, we propose strain 40Bstr401T represents a novel species in the genus Muricauda, for which the name Muricauda sediminis sp. nov. is suggested. The type strain is 40Bstr401T (=MCCC 1K04568T=KCTC 82139T).

Effects of congestion on drivers' speed choice: Assessing the mediating role of state aggressiveness based on taxi floating car data.

Inappropriate cruising speed, such as speeding, is one of the major contributors to the road safety, which increases both the quantitative number and severity of traffic accidents. Previous studies have indicated that traffic congestion is one of the primary causes of drivers' frustration and aggression, which may lead to inappropriate speed choice. In this study, the large taxi floating car data (FCD) was used to empirically evaluate how traffic congestion-related negative moods, defined as state aggressiveness, affected drivers' speed choice. The indirect effect of traffic delay on the cruising speed adjustment through the state aggressiveness was assessed through the mediation analysis. Furthermore, the moderated mediation analysis was performed to explore the effect of driver type, value of time, and working duration on the mediation role of state aggressiveness. The results proved that the state aggressiveness was the mediator of the relationship between travel delays and driving speed adjustment, and the mediation role was different across various driver types. As compared to the aggressive drivers, the normal drivers and the steady drivers tended to behave more aggressively after experiencing non-recurrent congestion during the early stage of the trips. When the value of time was high, steady drivers were more likely to adjust their speed choice although the effect was not statistically significant for other driver types. The validation results indicated that the speed model incorporating state aggressiveness could better predict the travel time than the traditional speed model that only considering the specific expected speed distribution. The prediction results for the manifest indicators of state aggressiveness, such as the maximum speed and the speed deviation, also demonstrated a reasonable reflection of the field data.

A study about immunomodulatory effect and efficacy and prognosis of human umbilical cord mesenchymal stem cells in patients with chronic hepatitis B-induced decompensated liver cirrhosis.

BACKGROUND AND AIM: The aim of our study was to investigate the immunomodulatory effect and short-term efficacy and long-term prognosis of decompensated liver cirrhosis patients caused by hepatitis B after a double transplantation with human umbilical cord mesenchymal stem cells (hUCMSCs). METHODS: Fifty inpatients were recruited and given the same medical treatments, receiving hUCMSCs injection intravenously. Fifty-three patients (Group B) matched for age, sex, and baseline alanine aminotransferase, aspartate aminotransferase, albumin, total bilirubin, prothrombin time, and model for end-stage liver disease score and Child-Pugh classification, acted as the control group. RESULTS: Interleukin-6 and tumor necrosis factor alpha levels markedly decreased, and interleukin-10 level apparently increased in Group A at 2 and 4 weeks after treatment. Transforming growth factor beta in Group A increased more remarkably at 2 weeks after treatment. T4 cells and Treg cells in Group A were apparently higher than those in Group B at 2 and 4 weeks after treatment, and T8 cells and B cells were significantly lower than those in Group B. Aspartate aminotransferase levels in Group A were dramatically declining at 8 and 12 weeks after treatment. Levels of albumin, total bilirubin, and prothrombin time in Group A were apparently improved from 4 to 12 weeks after treatment. The improvements in model for end-stage liver disease and Child-Pugh scores in Group A were notably superior to those in Group B from 4 to 36 weeks after treatment. There were no remarkable differences in the incidence of developing liver failure throughout the follow-up period, but the mortality rate of Group A was lower than that of Group B. CONCLUSION: This therapeutic method may be an appropriate choice for patients with decompensated liver cirrhosis.