1.
RSC Adv
; 12(30): 19265-19269, 2022 Jun 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35865588
RESUMO
A highly efficient method for the synthesis of azole derivatives via a direct aza-Michael addition of azoles to α,ß-unsaturated malonates using Cs2CO3 as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amplified to gram scale in excellent yield in the presence of 10 mol% of Cs2CO3.