1.
Org Lett
; 2(22): 3527-9, 2000 Nov 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11082026
RESUMO
[reaction: see text] beta-Amino acids are becoming increasingly attractive as intermediates in the synthesis of a variety of molecular structures. However, few methods are available for the synthesis of alpha-substituted beta-amino acids that are both readily scalable and highly stereoselective. Herein we report a new method for synthesizing alpha-substituted beta-amino acids that satisfies both of these requirements using enantiomerically pure pseudoephedrine as a chiral auxiliary.