Comparison of labor induction with titrated oral misoprostol solution between nulliparous and multiparous women.

AIM: To compare the outcomes of labor induction with oral misoprostol solution between nulliparous and multiparous women. METHODS: We retrospectively reviewed the medical records of all patients between 37 and 42 weeks of gestation with a Bishop score

Hourly oral misoprostol administration for terminating midtrimester pregnancies: a pilot study.

OBJECTIVE: This pilot study retrospectively evaluated the outcomes of medical induction of termination of midtrimester pregnancies with hourly oral misoprostol administration. MATERIALS AND METHODS: Sixteen women with living fetuses, who had undergone pregnancy termination at 12-25 weeks of gestational age, were reviewed. The method of induction was hourly oral administration of misoprostol, given at doses of 200 µg/hr for the first 12 hours and 400 µg/hr after 12 hours until delivery. Data including the induction-to-delivery interval and total dosage of misoprostol were recorded and analyzed. RESULTS: All 16 women successfully underwent vaginal termination within 36 hours. The median induction-to-delivery interval was 12.0 hours (range, 6.3-30.9 hours), with 13 women (81.3%) undergoing vaginal delivery within 24 hours. The median total dosage of misoprostol was 2,600 µg. The most common side effect was diarrhea, which was easily relieved by medication. CONCLUSION: Our preliminary results show that oral administration of misoprostol at hourly intervals is a promising method for terminating midtrimester pregnancies.