Longitudinal Bidirectional Relationships Between Maternal Depressive/Anxious Symptoms and Children's Tic Frequency in Early Adolescence.

Background: Previous studies have revealed an association between maternal depressive/anxious symptoms and children's tics. However, the longitudinal relationships between these symptoms remain unclear. We examined the longitudinal relationships between maternal depressive/anxious symptoms and children's tic frequency in early adolescence with a population-based sample. Methods: The participants consisted of 3,171 children and their mothers from the Tokyo Teen Cohort (TTC) study, a population-representative longitudinal study that was launched in Tokyo in 2012. Maternal depressive/anxious symptoms and children's tics were examined using self-report questionnaires at the ages of 10 (time 1, T1) and 12 (time 2, T2). A cross-lagged model was used to explore the relationships between maternal depressive/anxious symptoms and children's tic frequency. Results: Higher levels of maternal depressive/anxious symptoms at T1 were related to an increased children's tic frequency at T2 (ß = 0.06, p < 0.001). Furthermore, more frequent children's tics at T1 were positively related to maternal depressive/anxious symptoms at T2 (ß = 0.06, p < 0.001). Conclusions: These findings suggest a longitudinal bidirectional relationship between maternal depressive/anxious symptoms and children's tic frequency in early adolescence that may exacerbate each other over time and possibly create a vicious cycle. When an early adolescent has tics, it might be important to identify and treat related maternal depressive/anxious symptoms.

Assessing the hierarchy of personal values among adolescents: A comparison of rating scale and paired comparison methods.

INTRODUCTION: For assessing personal values, the rating scale method may not adequately reflect the hierarchical structure of personal values and tends to be influenced by response style bias. The paired comparison method is considered a promising alternative approach, because it engages comparative judgment and may reduce response style biases. The present study aimed to compare these two methods for assessing the hierarchy of personal values among adolescents. METHODS: A total of 191 community-dwelling adolescents aged 12-15 years old completed the rating scale and paired comparison version of the Brief Personalized Value Inventory. Descriptive statistics and latent class analyses were used to assess the difference between the rating scale and paired comparison methods. RESULTS: The two methods yielded similar rankings and means for personal values. The number of subgroups identified by latent class analysis was higher in the paired comparison method than in the rating scale method (10-class vs. 5-class). In the results using the rating scale method, there was a subgroup with high scores on all personal values items. CONCLUSIONS: The paired comparison method captured substantially more heterogeneity in the hierarchy of personal values among adolescents compared to the rating scale, which may be influenced by response style bias.

Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development.

AIM: Adolescence is a crucial stage of psychological development and is critically vulnerable to the onset of psychopathology. Our understanding of how the maturation of endocrine, epigenetics, and brain circuit may underlie psychological development in adolescence, however, has not been integrated. Here, we introduce our research project, the population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC), a longitudinal study to explore the neurobiological substrates of development during adolescence. METHODS: Participants in the first wave of the pn-TTC (pn-TTC-1) study were recruited from those of the TTC study, a large-scale epidemiological survey in which 3171 parent-adolescent pairs were recruited from the general population. Participants underwent psychological, cognitive, sociological, and physical assessment. Moreover, adolescents and their parents underwent magnetic resonance imaging (MRI; structural MRI, resting-state functional MRI, and magnetic resonance spectroscopy), and adolescents provided saliva samples for hormone analysis and for DNA analysis including epigenetics. Furthermore, the second wave (pn-TTC-2) followed similar methods as in the first wave. RESULTS: A total of 301 parent-adolescent pairs participated in the pn-TTC-1 study. Moreover, 281 adolescents participated in the pn-TTC-2 study, 238 of whom were recruited from the pn-TTC-1 sample. The instruction for data request is available at: http://value.umin.jp/data-resource.html. CONCLUSION: The pn-TTC project is a large-scale and population-neuroscience-based survey with a plan of longitudinal biennial follow up. Through this approach we seek to elucidate adolescent developmental mechanisms according to biopsychosocial models. This current biomarker research project, using minimally biased samples recruited from the general population, has the potential to expand the new research field of population neuroscience.

Response inhibition and anxiety in adolescents: Results from a population-based community sample.

BACKGROUND: Anxiety disorders are prevalent among adolescents; however, without objective behavioral markers, anxiety disorders in adolescent populations may often go undiagnosed. Response inhibition is considered as a possible behavioral marker, based on the results with two-gate design, which can aid in early detection of anxiety disorders. The aim of this study was to investigate the relationship between response inhibition and anxiety using a large-scale population-based adolescent sample with single-gate design. METHODS: We used data from the Tokyo Teen Cohort study which was a population-based survey in adolescence. Anxiety was assessed by the Child Behavior Checklist answered by primary caregivers. Response inhibition was measured using the Go/No-Go task. We estimated Pearson's correlation coefficient to test the relationship between response inhibition and anxiety. RESULTS: A total of 2,434 adolescents aged 11-13 years were included in our analyses. We found a significant but weak correlation between response inhibition and adolescent anxiety (r = 0.07, confidence interval 0.03-0.11, p < 0.001). Similar results were shown in most of subgroups according to gender, age, and intelligence. LIMITATIONS: The primary outcome was assessed only via parent-reported questionnaire, leading to potential informant bias. CONCLUSIONS: Response inhibition may not be considered as a suitable behavioral marker of adolescent anxiety.

Lithium levels in tap water and psychotic experiences in a general population of adolescents.

Recently, several epidemiologic studies have reported that lithium in drinking water may be associated with lower rates of suicide mortality, lower incidence of dementia, and lower levels of adolescents' depression and aggression at the population level. However, to our knowledge, no study has investigated lithium level in tap water in relation to psychotic experiences in a general population of adolescents. This is the first study to investigate this using a large dataset. Information on psychotic experiences, distress associated with these experiences, and depressive symptoms were collected in 24 public junior high schools in Kochi Prefecture in Japan. Samples were collected from sources that supplied drinking water to schools, and lithium levels were measured using atomic absorption spectrophotometry. The association of lithium levels with psychotic experiences, considering distress as a degree of severity, was examined using an ordinal logistic regression model with schools and depressive symptoms as random effects. In total, 3040 students responded to the self-reporting questionnaire (response rate: 91.8%). Lithium levels in tap water were inversely associated with psychotic experiences (p = 0.021). We concluded that lithium level in tap water was inversely associated with psychotic experiences among a general population of adolescents and may have a preventive effect for such experiences and distress.

Attentional bias and its association with anxious mood dynamics.

Attentional bias toward threatening stimuli is recognized as 1 of the most important cognitive vulnerability factors for anxiety. However, the association between anxious attention and negative moods has not been fully elucidated, particularly in terms of the effect of such bias on mood fluctuations in daily life. We examined the associations between attentional bias and emotional dynamics under a daily life setting. Participants (46 university students) completed the dot-probe task in the laboratory, after which they entered a 6-day experience sampling measurement to assess temporal fluctuations of momentary levels of anxious mood and occurrence of stressful events. The results showed that attentional bias was significantly correlated with increased temporal instability of anxious mood. Furthermore, attentional bias was also associated with enhanced emotional reactivity immediately after occurrence of the stressful event, but not with either the sensitivity to detect stressors or to the recovery process aimed at calming the stress-induced anxious mood on a longer time scale. These findings suggest that attentional bias is associated with the acute impact of a stressor on moods, as evidenced by the increased temporal instability and stress-reactivity of anxious mood. (PsycINFO Database Record

Stuttering Thoughts: Negative Self-Referent Thinking Is Less Sensitive to Aversive Outcomes in People with Higher Levels of Depressive Symptoms.

Learning theories of depression have proposed that depressive cognitions, such as negative thoughts with reference to oneself, can develop through a reinforcement learning mechanism. This negative self-reference is considered to be positively reinforced by rewarding experiences such as genuine support from others after negative self-disclosure, and negatively reinforced by avoidance of potential aversive situations. The learning account additionally predicts that negative self-reference would be maintained by an inability to adjust one's behavior when negative self-reference no longer leads to such reward. To test this prediction, we designed an adapted version of the reversal-learning task. In this task, participants were reinforced to choose and engage in either negative or positive self-reference by probabilistic economic reward and punishment. Although participants were initially trained to choose negative self-reference, the stimulus-reward contingencies were reversed to prompt a shift toward positive self-reference (Study 1) and a further shift toward negative self-reference (Study 2). Model-based computational analyses showed that depressive symptoms were associated with a low learning rate of negative self-reference, indicating a high level of reward expectancy for negative self-reference even after the contingency reversal. Furthermore, the difficulty in updating outcome predictions of negative self-reference was significantly associated with the extent to which one possesses negative self-images. These results suggest that difficulty in adjusting action-outcome estimates for negative self-reference increases the chance to be faced with negative aspects of self, which may result in depressive symptoms.

Is self-positive information more appealing than money? Individual differences in positivity bias according to depressive symptoms.

The self-positivity bias, which is inherent to healthy people, is known to be blunted in depression. The lack of positive or excessive negative self-reference is considered to be a potential mechanism underlying depressive rumination. However, the motivational factors that drive people to approach and avoid emotional self-related materials are still unclear. Therefore, we measured intrinsic motivation that is associated with emotional self-references by using a reward-based decision-making task (pay-per-view paradigm). Forty-nine undergraduates completed two tasks in which they were asked to choose between negative vs. positive references (Task 1) and self vs. other references (Task 2) for variable monetary rewards. Participants with lower levels of depressive symptoms showed a self-positivity bias, sacrificing rewards for the opportunity to engage in positive self-reference, whereas those with higher levels of depressive symptoms had no specific preference for either negative or positive self-reference (Task 1). However, all participants sacrificed monetary rewards for the opportunity for self-reference versus other reference, regardless of the symptom level or the primed valence (Task 2). Together, these findings suggest that depressive cognition could be characterised by the lack of intrinsic motivation for positive self-reference, which is attributable to the biased valence selection, but not to self-other preferences.

Exploring the cognitive load of negative thinking: a novel dual-task experiment.

BACKGROUND AND OBJECTIVES: Females are more likely to engage in the preoccupation of past negative experiences than males, which might contribute to their greater tendency toward depression. However, there is limited understanding regarding the cognitive basis for the negative autobiographical information processing of females. In the present study, we assessed the cognitive resources required for negative thinking, by using a novel dual-task paradigm that combined think-aloud and time-estimation tasks. METHODS: Fifty-three Japanese undergraduate students were asked to think aloud about personal past or future emotional episodes for a particular duration. In addition, they were asked to estimate the duration of their speech. Their estimates were compared to the actual time taken, and the errors were used as indices of cognitive burden during the speech task. RESULTS: As compared to males, females exhibited greater judgment errors, particularly when thinking about their past negative experiences. This suggests that females allocate more attentional resources toward thinking about the past. LIMITATIONS: Participants could rehearse the task during the time reproduction phase, and the quality of the rehearsal and their memory capacity might have influenced the accuracy of their duration judgment. CONCLUSIONS: Females tend to allocate more attentional resources than males to thinking about past negative episodes, which in turn might be associated with reduced availability of resources for central cognitive control processes such as inhibition of and switching away from processing of negative autobiographical information.

Repetitive thought and self-reported sleep disturbance.

Repetitive thought has been focused upon as a transdiagnostic risk factor for depression, anxiety, and poor physical health. Among the forms of repetitive thought, rumination and worry are considered to play important roles in the onset and maintenance of insomnia. However, there have been few attempts to clarify the similarities, differences, and interaction between the functions of rumination and worry in sleep problems. Furthermore, no study has investigated the prospective relationships between these two forms of repetitive thought and sleep disturbance. In the present study, we examined the prospective associations between repetitive thought and subjective sleep quality, measured by a self-report questionnaire. A total of 208 undergraduates participated in a 2-wave longitudinal survey with an interval of 3weeks between assessments. Hierarchical multiple regression analyses showed that baseline rumination predicted reduction in the follow-up assessment of subjective sleep quality, controlling for levels of depressive and anxious symptoms. This main effect of rumination was qualified by the levels of worry; for individuals with higher levels of worry, rumination was associated with greater reduction in subjective sleep quality. These results suggest that both rumination and worry have unique associations with sleep and that their interaction is especially important in sleep problems.

[The effect of cognitive load on the temporal focus of mind wandering].

The present study investigated the effects of cognitive load on the temporal focus of mind wandering. Participants performed a cognitive-load task under three load conditions (0 back, 1 back, 2 back). During each condition, thought sampling was conducted to measure task-unrelated thoughts. When a thought probe was presented, participants responded what they were just thinking. The results showed that future-related thoughts were reduced with increasing cognitive-load. On the other hand, past-related thoughts were not reduced under moderate cognitive-load but were under high cognitive-load. This indicates that future-related thoughts require additional resources. Furthermore, future-related thoughts were more prevalent than past-related thoughts under low cognitive-load. These findings may indicate that a future prospective bias is important for survival.