Heavy metals contamination of seafood from the crude oil-impacted Niger Delta Region of Nigeria: A systematic review and meta-analysis.

This study aims at computing the pooled mean estimate (PME) and health risks of heavy metals in seafood obtained from the Niger Delta Region of Nigeria (NDRN), using data from existing literatures. Pubmed, Scopus and Google Scholar were searched to retrieve articles that investigated the heavy metal contents of edible seafood from the NDRN. Search hits were screened against predetermined criteria following which relevant data were extracted from eligible articles. The PME for each metal was computed by performing a maximum likelihood random effect model meta-analysis using the R Studio Software. Outcome from the meta-analysis involving 58 studies and a total of 2983 seafood samples revealed the following PMEs (mg/kg dry wt seafood) for the investigated heavy metals: As (0.777), Cd (0.985), Co (4.039), Cr (2.26), Cu (11.45), Fe (143.39), Hg (0.0058), Mn (13.56), Ni (5.26), Pb (4.35), and Zn (29.32). The health risk assessment suggests that seafood from this region poses considerable carcinogenic and non-carcinogenic risks to human consumers. Our finding calls for urgent actions aimed at identifying and eliminating point sources of heavy metals pollution of the NDRN marine environment. Inhabitants of NDRN are encouraged to reduce seafood consumption while diversifying their protein sources to include non-seafood options.

Evaluation of Serum Interleukin 6, Tumor Necrosis Factor-Alpha, and Interferon-Gamma Levels in Relation to Body Mass Index and Blood Pressure in HIV Seropositive Pregnant Women Coinfected with Malaria.

Malaria and HIV are leading causes of morbidity and mortality, particularly in sub-Saharan Africa. Both diseases are highly endemic and have a wide geographic overlap with severe impact on pregnancy. This was a case-control study designed to evaluate the levels of interleukin -6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) and their relationship with some anthropometric indices such as body mass index (BMI) and blood pressure in HIV-malaria coinfected women attending antenatal clinic at Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria. 122 pregnant women and 30 nonpregnant women (control) aged between 18 and 42 years were recruited for the study. Screening of HIV antibodies was done using a national algorithm. Peripheral malaria was determined using rapid detection and the Giemsa stain technique. Cytokines were assayed using the enzyme-linked immunosorbent assay technique. HIV-malaria coinfected pregnant women showed significantly higher levels of IL-6, IFN-γ, TNF-α, and blood pressure with reduced BMI value compared with HIV seronegative pregnant and nonpregnant control participants (p ≤ 0.001, respectively). The findings indicated significant cytokine imbalance which suggests an active inflammatory process and reduced cellular immunity. The increased BMI and blood pressure level observed indicate overweight and possible hypertension which could subsequently lead to preeclampsia and other adverse pregnancy outcomes.