Assuntos
Neoplasias Ósseas/cirurgia , Histiocitoma Fibroso Benigno/cirurgia , Adolescente , Adulto , Fatores Etários , Idoso , Neoplasias Ósseas/diagnóstico por imagem , Criança , Diagnóstico Diferencial , Feminino , Histiocitoma Fibroso Benigno/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Radiografia , Fatores SexuaisRESUMO
An osteolytic bone tumor was found in a 12-month-old male NZB mouse. Macroscopically and histologically this tumor was angiosarcoma originating in bone with distant metastasis present in the spleen. The primary tumor was successfully transplanted in the back subcutaneous tissue of syngeneic mice, and the characteristics of the transplants, were found to be similar to those of the primary tumor. The ultrastructure of tumor is described.
Assuntos
Neoplasias Ósseas/veterinária , Hemangiossarcoma/veterinária , Camundongos Endogâmicos NZB , Doenças dos Roedores/patologia , Tíbia , Animais , Neoplasias Ósseas/patologia , Neoplasias Ósseas/ultraestrutura , Hemangiossarcoma/patologia , Hemangiossarcoma/ultraestrutura , Masculino , Camundongos , Transplante de Neoplasias , Transplante HomólogoRESUMO
Five cases of malignant fibrous histiocytoma originating in the femur and tibia, sometimes with local recurrences, are reported. Histological and clinical characteristics of this lesion were similar to those in soft tissues with the same disease. The present histiocytomas were observed by electron microscopy and shown to consist of 5 types of neoplastic cells which were regarded as undifferentiated cells, histiocyte-like cells, which were predominating, fibroblast-like cells, multinucleated giant cells and xanthomatous cells. These findings led us to confirm the existence of malignant fibrous histiocytoma originating in bone as well as in soft tissues.
Assuntos
Neoplasias Ósseas/ultraestrutura , Histiocitoma Fibroso Benigno/ultraestrutura , Adulto , Núcleo Celular/ultraestrutura , Feminino , Fêmur/ultraestrutura , Fibroblastos/ultraestrutura , Histiócitos/ultraestrutura , Humanos , Corpos de Inclusão/ultraestrutura , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/ultraestrutura , Tíbia/ultraestruturaRESUMO
Existence of an entity called malignant fibrous histiocytoma of bone was emphasized, based on two of our own cases experienced recently and on previous reports related to this tumor. Histologically the tumor resembles markedly the malignant fibrous histiocytoma originating in the soft part. In addition, an attempt was made to clarify its biological behavior, histological subclassification and criteria to be malignant and differential diagnoses from several other bone diseases which sometimes mimic this malignant bone tumor.