Efficiency of casein phosphopeptide amorphous calcium phosphate versus topical fluorides on remineralizing early enamel carious lesions - A systematic review and meta analysis.

Objective: To assess the remineralizing efficiency of caesin phosphopepdide amorphous calcium phosphate (CPP-ACP) versus topical fluorides on early enamel lesions in vivo. Data sources: PubMed, Web of Science, Scopus, EBSCO were searched based on the PICOS criteria up to December 2022 with English language restriction. All relevant studies were subjected to two separate reviews before being included at the title, abstract, and full text levels. Study selection: 41 studies were reviewed and 11 selected for inclusion in the final sample for the review. All were randomized clinical trials with the follow-up period of the studies ranging from 3 to 12 months. Out of the 11 studies, only two are with low risk of bias on assessment with Cochrane risk of bias assessment tool, while the other nine articles were with the moderate and high risk of bias. Conclusions: Conflicting evidence exists on the clinical efficacy of CPP-ACP compared to the various fluoride forms tested, and no adverse effect associated with CPP-ACP use was discovered in comparison to fluorides that had certain detrimental health impacts. Although, the review results in favor of both fluorides and CPP-ACP with similar clinical efficiency, when ill effects are considered the CPP-ACP can be a choice of remineralizing early enamel lesions. However, before concrete suggestions can be given, high-quality, well-designed clinical research in this area are still necessary. Clinical significance: A considerable remineralizing impact has been shown in both in vitro and in vivo experiments, making CPP-ACP/CPP-ACPF a more promising remineralizing agent than fluorides. Therefore, this can be applied clinically to early enamel carious lesion.

Anticancer potential of thiocolchicoside and lauric acid loaded chitosan nanogel against oral cancer cell lines: a comprehensive study.

The present study explored the anticancer activity of a Chitosan-based nanogel incorporating thiocolchicoside and lauric acid (CTL) against oral cancer cell lines (KB-1). Cell viability, AO/EtBr dual staining and Cell cycle analysis were done to evaluate the impact of CTL nanogel on oral cancer cells. Real-time PCR was performed to analyze proapoptotic and antiapoptotic gene expression in CTL-treated KB-1 cells. Further, molecular docking analysis was conducted to explore the interaction of our key ingredient, thiocolchicoside and its binding affinities. The CTL nanogel demonstrated potent anticancer activity by inhibiting oral cancer cell proliferation and inducing cell cycle arrest in cancer cells. Gene expression analysis indicated alterations in Bax and Bcl-2 genes; CTL nanogel treatment increased Bax mRNA expression and inhibited the Bcl-2 mRNA expression, which showed potential mechanisms of the CTL nanogel's anticancer action. It was found that thiocolchicoside can stabilize the protein's function or restore it as a tumour suppressor. The CTL nanogel exhibited excellent cytotoxicity and potent anticancer effects, making it a potential candidate for non-toxic chemotherapy in cancer nanomedicine. Furthermore, the nanogel's ability to modulate proapoptotic gene expression highlights its potential for targeted cancer therapy. This research contributes to the growing interest in Chitosan-based nanogels and their potential applications in cancer treatment.

Prevalence of Occupational Injuries of the Oral and Maxillofacial Region and Their Covariates Among Building Construction Workers in Chennai.

Background and aim With many risky environmental conditions, civil construction sites are prone to physical injuries, especially those pertaining to the oral and maxillofacial regions. The current study was an effort to assess the magnitude and pattern of such oral and maxillofacial injuries and the factors associated with them. Methodology This descriptive study was carried out on 524 construction workers, of whom 254 met the inclusion criteria related to work site injuries. An interviewer-administered proforma with basic demographic details is used in conjunction with an intraoral examination to classify the dental injury. Descriptive statistics were done to evaluate the frequency of injury occurrence, while inferential statistics, including the chi-square test and regression analysis, were done to evaluate the association between injury and the variable under concern. Result The study includes a total of 254 participants, with ages ranging from 20 to above 50 years, of whom 230 (91%) were males and 24 (9.4%) were females. The majority, 200 (78.7%), were unskilled laborers, and 195 (76.7%) were migrant workers with language barriers. It was found that 95 (76.7%) had a history of dental injury alone, while 59 (23.2%) had a history of oral maxillofacial injury. Among the reasons for injury, the increased odds ratios (OD) were noted in the collapse of the surrounding area as 0.050 (0.029-0.075), rainy season 1.001 (0.891-1.281), unskilled labor 1.020 (0.910-1.30), and migrants 1.010 (0.901-1.200). The OD for males is 2.052 (1.941-2.101). Conclusion The current study confirms that the magnitude of workplace-related injuries is significant, and the majority of them stem from basic language barriers among migrant workers and a lack of knowledge to adhere to safety protocols and instructions given.

Working hours impact on the sleep quality and oral health status among migrant construction workers in Chennai.

Background: Nowadays, a shift in our lifestyle which espouses long working hours and low sleep quality can have a direct impact on the general health and oral health status. Sleep deprivation results from intense long working hours. Aim: To recognize the impact of long working hours, on sleep and oral health assessments of migrant construction workers. Materials and Methods: This is a cross-sectional study conducted among migrant construction workers working in Chennai comprised of 1,521 participants. The sleep quality was assessed using the Insomnia Severity Scale-7 and the working hours was found using the Google forms and their oral health status was assessed using the Oral hygiene index- Simplified (OHIS-S) and the Decayed Missing and Filled teeth (DMFT) index. The data were analysed using IBM SPSS Statistical Software version 23.0. Statistical tests like the Chi-square association and one-way Analysis of variance (ANOVA) (normally distributed) were used for the analysis of three group comparisons. Results: From the study results, most of the participants were between 25 and 35 years, smokers, had negligence on oral health and had poor sleep quality due to their long working hours. On the association between the working hours per week and OHIS, DMFT and Insomnia Severity Scale total score, a statistically significant relationship was found using the one-way ANOVA. Conclusion: The results from our study brought neglected oral health care of the construction workers into the limelight which will help us in our future efforts to improve the oral health of the construction workers.

Determination of salivary cortisol and salivary pH level in gaming teenagers - A cross-sectional study.

Introduction: Internet gaming disorder and cybervictimization has a disproportionate increase during the COVID 19 pandemic. Teenagers and adolescents have high risk for addiction to online gaming. Online gaming increases the stress level of the users affecting the general and the oral health. The study aims to determine the salivary cortisol and salivary pH among the gaming teenagers. Materials and methods: The cross-sectional study recruited 45 gaming teenagers with the mean age of 15.5 years. The participants were stratified according to the type of online gaming played as mind, aggressive and betting gaming. Their salivary pH and salivary cortisol were assessed. The collected data was analyzed using SPSS version 23. Results: The mean salivary pH was found to be less among females playing aggressive games (7.11 ± 0.30) and males playing mind games (7.24 ± 0.16). Salivary cortisol level was found to be statistically high in males (6.66 ± 1.33) and females (7.82 ± 0.66) playing aggressive games. The sub-group analysis of salivary pH and cortisol for gender showed a significant difference in the mean salivary cortisol level (p < 0.05) with no difference in the salivary pH (p > 0.05). Based on the number of hours spent in online gaming, there was a significant increase in the mean salivary cortisol level among the participants playing >3 h (p < 0.05). Conclusion: Salivary cortisol is high among individuals playing aggressive games compared to mind and betting games. Also, salivary cortisol is high in females compared to males with no change in salivary pH.

Antioxidant, anti-inflammatory activity of Thymus vulgaris-mediated selenium nanoparticles: An in vitro study.

Background: Nanotechnology is the specialty associated with material science and biology, rather than a particular field. It entails the method of particles at nanoscale called Nanoparticles, wherein they have control over bulk macroscopic properties of the identical material. The "drug nanocarrier," selenium possesses strong antibacterial, antioxidant and anti-cancer as well as anti-inflammatory properties. As the medicinal plant Thymus vulgaris possesses a lot of phytochemicals, this study was conducted to assess the anti-inflammatory and antioxidant activity of selenium nanoparticles (SeNps) reinforced with T. vulgaris. Materials and Methods: Anti-inflammatory activity, antioxidant activity of SeNps reinforced with T. vulgaris extract were assessed using bovine serum albumin and 2, 2-diphenyl-1-picrylhydrazyl assay, respectively, at 10, 20, 30, 40, and 50 µL. Results: The values for anti-inflammatory property of nanoparticles were higher than the standard values at 30, 40, and 50 µL concentrations. Percentage of inhibition was highest at 40 µL (87.7%) and 50 µL (92.6%). The values for antioxidant property of nanoparticles were found to be higher than the standard values at 10, 20, and 30 µL concentrations. Percentage of inhibition was highest at 30 µL (68.3%). Conclusion: SeNps reinforced with T. vulgaris extract have a potential as an anti-inflammatory and antioxidant agent and can be used as an alternative to commercially available products.

Assessment of anxiety, depression and nicotine dependence among construction workers in Chennai - A cross sectional study.

Background: Tobacco dependence has been identified as one of the important public health problems faced by both developing and also the developed countries. Anxiety and depression might also influence the quality of life of the tobacco users which increases the dependence on nicotine. Materials and methods: The study was conducted among male construction workers with the habit of tobacco (production workers and labourers) in Chennai who were all working under different organizations from June 15, 2021 to August 15, 2021(n = 416). GAD-7 anxiety severity questionnaire, Patient Health Questionnaire-9, Fagerstrom test for nicotine dependence was used to collect the data. Statistical analysis was done using Statistical Package for the Social Sciences Version 23. Results: Since the data is normally distributed, Parametric tests have been carried out. A highly statistically significant difference (p = 0.00) was found on finding the association of fagerstrom nicotine dependence with the groups (smokers, smokeless and both users) from One-way ANOVA test. A positive correlation was found between nicotine dependence, GAD-7(r = 0.82) and PHQ-9(r = 0.79). Conclusion: Nicotine dependence plays a vital role in an individual's anxiety and depression level. Higher the nicotine dependence higher their anxiety and depression level. Long working hours also plays an evident role which influences workers mental health directly.

Prevalence and dependency of tobacco use among tribal gypsies in Thoothukudi district - A cross sectional study.

INTRODUCTION: The Narikuravars or "gypsy" are a semi vagrant groups distributed across borders, but primarily live in Tamil Nadu, India. They are notorious to face discrimination that interprets into low education level, low socio-economic status and lack of pertinent access to health care. The focus of the present study is to determine the prevalence and dependency with tobacco use among tribal gypsies in Thoothukudi district. MATERIALS AND METHODS: The study design of the present study was a cross sectional which was done in Thoothukudi district in the month of December, 2019. Oral health status of the study population was analysed by WHO assessment form (adults), 2013. Tobacco dependence was analysed by Fagerstrom Nicotine dependency scale. The inclusion criteria were to include every gypsy person who is a citizen of Thoothukudi district and of all ages. The study included all the narikuravars (164) whose origin is Thoothukudi district. SPSS version 20.0 was used for statistical analysis. Descriptive statistics and Chi square tests were done to establish the distribution and association of the variables, respectively. RESULTS: The total study participants of this cross-sectional study were 164, among them 128 were adults and 36 were children. Results revealed that among the adult population 64.55% were using tobacco, among them 29.1% were using smoking tobacco, 63.4% were using smokeless tobacco and 7.5% were using both. Medium nicotine dependency was more prevalent in both smoking and smokeless tobacco users (82.75% and 53.57%). The association between prevalence of tobacco use and gingival bleeding was statistically significant. Gingival bleeding was present in 88.9% of tobacco users and 11% of non-users (p value- 0.01). Significant association was found between gender and tobacco usage (p value- 0.042), dental erosion and tobacco usage (p value- 0.007). There exists significant association established between gender and nicotine dependency. (p value - 0.000). CONCLUSION: More than 60% of the adult study participants were using some form of tobacco. Medium tobacco dependency was prevalent among tobacco users. The tribal people have no access to all the services as their counterparts and it's our duty to educate them and create an insight about the ill effects of tobacco usage.

A qualitative study on attitude towards smoking, quitting and tobacco control policies among current smokers of different socio-economic status.

INTRODUCTION: Tobacco consumed as smoke and smokeless forms is an important preventable public health issue projected to be the single largest cause of mortality worldwide. The aim of the study was to qualitatively assess the attitudes towards smoking, quitting and tobacco control policies among current smokers of different socio-economic status. MATERIALS AND METHODS: An in-depth interview for 10 current smokers and a focus group discussion comprising of 10 current smokers was conducted with a guide and moderator which was audio recorded. About 6, 8 and 6 subjects from white collar, blue collar, and black collar employee status participated in the study. Their tobacco consumption and dependence using the Fagerstrom Test for Nicotine Dependence scale (FTNDS) was assessed. RESULTS: About 50% of the participants had low; 30% had moderate and 20% had high nicotine dependency. Most of the participants started smoking by peer influence and continued as it made them to socialize. Relapses during their quit attempt was mainly due to work stress. Participants heard about the control of tobacco act but were unsure of the features in it. They perceived that no changes will happen if government bans production and selling of tobacco products. Also anti-tobacco commercials in social media will have no use. Nicotine replacement therapy may help in quitting the habit. CONCLUSION: The study concluded that people in low socio-economic status had high nicotine dependency with inadequate knowledge on tobacco control policies. They strongly believe that an individual's self-restrain only can succeed him in quitting the habit.

Quality of life among head and neck cancer treated patients in South India: A cross-sectional study.

BACKGROUND AND AIM: The impact of oral health related disease and treatment on the patient's overall well-being and functioning is a topic of growing interest in clinical research and practice. Research shows that there is a significant reduction in the quality of life for the patients throughout the treatment of head and neck cancer. Therefore, the aim of the study is to assess the quality of life among treated head and neck cancer patients. MATERIALS AND METHOD: The cross sectional study was conducted among 225 head and neck cancer patients. The European Organization for Research and Treatment of Cancer (EORTC QLQ C-30), Quality Of Life Head and Neck35" (QLQ-HN35) instruments were used to assess their quality of life. The study population was divided into three groups based on the treatment done: Group I (Surgery), Group II (Surgery and Radiotherapy) and Group III (Surgery, Radiotherapy and Chemotherapy). Independent t-test and one way ANOVA test were done to analyze the data. RESULTS: Trouble with opening mouth (34.66 â€‹± â€‹30.58) was one of the highest rated symptoms among the study population. Salivary dysfunction leading to dry mouth (33.33 â€‹± â€‹34.06), sticky saliva (33.33 â€‹± â€‹26.72) were also found to be severe. Among the three groups, the Global Health Status, Symptom Scale mean scores were more high in Group I, Functional Scale and H&N35 symptoms mean scores was high in Group III however no statistical significance was observed (p â€‹> â€‹0.05). CONCLUSION: Head and neck cancer has severe effects on the quality of life. As observed from the findings of the current study, Global Health Status indicated a healthy level of living among patients who have undergone surgery alone; head and neck symptoms were more severe and problematic among patients who had surgery and radiotherapy. Therefore, assessing health related quality of life can be a factor that is weighed against treatment burden, toxicity, survival benefit. It can be more integral to treatment planning, refining treatment protocols and a better post-operative care and support.

Comparison and Evaluation of the Retention, Cariostatic Effect, and Discoloration of Conventional Clinpro 3M ESPE and Hydrophilic Ultraseal XT Hydro among 12-15-year-old Schoolchildren for a Period of 6 Months: A Single-blind Randomized Clinical Trial.

INTRODUCTION: Pit and fissures are more prone to caries as compared to smooth surfaces. Sealing the pit and fissures with sealants is considered to be highly effective in the prevention of pit and fissure caries. Hydrophobic sealants are technique sensitive in nature. Ultraseal XT Hydro sealant is moisture tolerant which incorporates the benefits of both hydrophilic and hydrophobic sealants into one unique chemistry. Hence, the study was conducted to compare and evaluate the retention, cariostatic effect, and discoloration of conventional Clinpro™ 3M™ ESPE™ and hydrophilic Ultraseal XT Hydro sealants among 12-15-year-old schoolchildren for 6 months. MATERIALS AND METHODS: It was a single-blinded, randomized split-mouth clinical trial. Schoolchildren aged 12-15 years were recruited in this clinical trial. Clinpro sealant and Ultraseal XT Hydro were placed in the right and left quadrant molars, respectively, and were assigned as group I and II. The sample size arrived was 60 teeth per group and at 30 patients based on the computer-generated random sequence. Sealant coverage between the two sealants was compared using Mann-Whitney test and Z test for proportions. RESULTS: After 6 months, it was seen that 10 teeth out of 44 (22.72%) with Clinpro had the sealant covering all the fissures compared to Ultraseal XT Hydro which was only 9%. Fifty-nine percent of retention rate was seen with Clinpro compared to Ultraseal XT Hydro sealant (27.27%). Caries incidence was higher in the case of group II. No difference was observed with regard to the discoloration of the sealants. CONCLUSION: It was concluded that for a longer follow-up period conventional Clinpro™ 3M™ ESPE™ was better than Ultra XT Hydro seal in terms of retention and cariostatic effect. HOW TO CITE THIS ARTICLE: Mohapatra S, Prabakar J, Indiran MA, et al. Comparison and Evaluation of the Retention, Cariostatic Effect, and Discoloration of Conventional Clinpro 3M ESPE and Hydrophilic Ultraseal XT Hydro among 12-15-year-old Schoolchildren for a Period of 6 Months: A Single-blind Randomized Clinical Trial. Int J Clin Pediatr Dent 2020;13(6):688-693.

Concerns with oral health care services for adults with cognitive and intellectual disabilities.

It is of interest to document data on oral health care services for adults with cognitive and intellectual disabilities. Hence, a study protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO) with registration number: CRD42020150759. We used PubMed, Science Direct, LILACS and SCIELO to collect data from known literature using keywords containing MESH (Medical Subject Headings) terms. The risk of bias rating for the collected data was calculated using the Newcastle-Ottawa assessment Scale. The AHRQ (Agency for Healthcare, Research and Quality) was used for classifying the level of evidence in the collected data. Analysis of available data shows that there is a lack of dentists with adequate skills to treat people with disabilities resulting in high cost for dental treatment. Thus, we conclude that inconvenient location of dental clinic, lack of dentists willing to treat people with disabilities and attitude of dental staff towards people with learning disabilities were considered as barriers and challenges faced for dental health service utilization in this context.

Oral health behaviour, practices, status and the dental treatment needs among paliyan and pulayan tribes in India.

It is of interest to document the The Oral Health heigene data among the paliyan and pulayan tribes in India. The Paliyan and Pulayan tribes inhabit a narrow strip of Western Ghats in the hilly regions of Madurai, Dindigul, Theni, Tirunelveli and Virudhunagar districts of Tamil Nadu. Subjects aged 5yrs and above are used in this study. The WHO assessment form was used to assess the oral health status. Results show that 589 (58%) ignored the oral health problems, 225 (22.2%) relied on self-medications, 142 (14%) consulted a general physician, 35 (3.5%) had visited a dentist and the remaining 23 (2.3%) were dependent upon over the counter medications from a pharmacy. Thus, the prosthetic need was highest among the 55 + yrs age group, 36 (48.6%) required maxillary prosthesis and 21 (28.4%) required mandibular prosthesis.