RESUMO
Sixteen cases of malignant soft tissue sarcoma (STS; 10 canines and six felines) were treated with a novel triple therapy that combined photodynamic therapy, hyperthermia using indocyanine green with a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed over an interval of 1 to 2 weeks and was repeated three to 21 times. No severe side effects, including severe skin burns, necrosis, or skin suture rupture, were observed in any of the animals. No disease recurrence was observed in seven out of 10 (70.0%) dogs and three out of six (50.0%) cats over the follow-up periods ranging from 238 to 1901 days. These results suggest that PHCT decreases the risk of STS recurrence. PHCT should therefore be considered an adjuvant therapy for treating companion animals with STS in veterinary medicine.
Assuntos
Antineoplásicos/uso terapêutico , Doenças do Gato/terapia , Doenças do Cão/terapia , Verde de Indocianina/uso terapêutico , Fármacos Fotossensibilizantes/uso terapêutico , Sarcoma/veterinária , Animais , Doenças do Gato/tratamento farmacológico , Doenças do Gato/cirurgia , Gatos , Terapia Combinada/veterinária , Doenças do Cão/tratamento farmacológico , Doenças do Cão/cirurgia , Cães , Hipertermia Induzida/veterinária , Fotoquimioterapia/veterinária , Sarcoma/tratamento farmacológico , Sarcoma/cirurgia , Sarcoma/terapiaRESUMO
We report a case of bilateral severe bronchial stenosis which was caused by compression by ascending and descending portions of the aorta. Asthma-like symptoms developed 9 years previously and dilation of the ascending aorta was noted 2 years previously. Bronchial obstruction was suspected because of diminishing breath sounds in the left hemithorax. Investigations suggested existence of a vascular ring consisting of the left aortic arch, right descending aorta and possibly the right ligamentum arteriosum. The patient fell in shock during bronchoscopy. Emergency implantations of bronchial stents in the right bronchus and then the left bronchus were made. Because of the patient's poor lung function, there was an extremely high risk for surgical treatment. Although airway stenosis caused by vascular anomaly in elderly patients is very rare, when asthma-like symptoms developed in patients with a right-sided descending aorta, physicians should consider the possibility of such condition.