Interim Results of the BYHEART Observational Study: Exogenous Phosphocreatine Effect on the Quality of life of Patients with Chronic Heart Failure.

Aim      Improvement of quality of life is one of the most important goals for the treatment of patients with chronic heart failure (CHF). This study searched for ways to increase the efficiency of CHF treatment based on parameters of quality of life in CHF patients during and after the treatment with exogenous phosphocreatine (EP).Material and methods  The effect of a single course of EP treatment on quality of life of patients with functional class (FC) II-IV CHF with reduced or mid-range left ventricular ejection fraction was studied as a part of the all-Russia prospective observational study BYHEART. The presence of FC II-IV CHF and a left ventricular ejection fraction <50 % were confirmed by results of 6-min walk test (6MWT) and findings of echocardiography after stabilization of the background therapy.Results An interim data analysis showed that the course of EP treatment was associated with a significant improvement of quality-of-life indexes as determined by the Minnesota Living with Heart Failure Questionnaire (LHFQ) total score. These indexes significantly increased and remained at a satisfactory level for 6 mos. following completion of the treatment course. Also, the treatment significantly beneficially influenced the clinical condition of patients (heart failure severity scale), results of 6MWT, and the increase in left ventricular ejection fraction.Conclusion      The conclusions based on results of the interim analysis should be confirmed by results of the completed study. Complete results are planned to be published in 2022.

[The optimization of technique of detection of cryoglobulins in conditions of clinical diagnostic laboratory].

The technique is proposed to evaluate cryoclobulins associated with IgM and IgG on the basis of detection of immune complexes circulating in healthy individuals and patients with liver cirrhosis. It is demonstrated that in patients with liver cirrhosis content of cryoclobulins associated with IgM increases almost twice and those associated with IgG more than two and a half times as compared with healthy individuals. It is established that in healthy individuals cryoclobulins are also present in blood in small amount. The proposed approach to detection of cryoclobulins permits to minimize time of implementation of study and also discharge of reagents.

[Characteristics of psychologic features of tantalum production workers].

The article covers results of psychologic examination of apparently healthy workers of contemporary tantalum production. The authors describe changes in psychoemotional state of workers engaged into major tantalum production workshops, in accordance with occupational length of service.

[Physiologic shiftwise evaluation of respiratory system changes in miners engaged into underground coal mining].

Functional shiftwise evaluation of physiologic respiratory parameters was conducted in 166 miners. The conclusion was that each separate occupation has specific requirements.

[Hygienic evaluation of work activities in employees engaged into open-cast mining and chromium-ore concentration].

Despite contemporary equipment usage on mining enterprises, work conditions are influenced by some hazards.

[Hygienic evaluation of work conditions in shift open-cast mining work in North Kazakhstan].

Shift open-cast development and mining take place in Shubarkul coal deposit situated in semidesert with sharply continental climate. Health state and work capacity of the miners are influenced by climate, occupational and social environmental hazards.

[Automated database in analysis of pneumoconiosis prevalence in coal miners].

Using simulator of forecasting dust occupational diseases with automated information system, the authors analysed risk of pneumoconioses development in coal miners.

[Evaluating general and occupational morbidity on mining enterprises of Kazakhstan].

Evaluating risks of occupational and occupationally mediated diseases is a main parameter in further social and hygienic monitoring of work conditions and health state among mining industry workers.

[Using biologically active supplements to improve psychoemotional state in teenagers].

To improve mental facilities and psychoemotional state in teenagers of occupational schools, the authors recommend using biologically active supplements during studies.

[Using complex of respiratory exercises in miners training].

Using complex of respiratory exercises in occupational selection practice enables better training for work in extreme conditions of coal industry.

[Occupational fitness of workers in coal mining industry].

Specified criteria of occupational fitness are adequate for optimizing material expenses within the system "human-machine" and during occupational training for work in extreme conditions of coal industry.

[Registration information systems for occupational diseases of dust etiology].

The elaboration of a computer-aided system for registration and analysis of occupational diseases (OD) is extremely important to obtain valid data on the size and composition of a contingent of registered patients; on the distribution of patients by nosological entities and the severity of a pathological process; on the frequency of complications and comorbidity; on the presence of harmful industrial factors that favor disability and present a risk for OD.

[Psychophysiologic state of teenagers during occupational training]. / Psikhofiziologicheskoe sostoianie podrostkov v dinamike professional'nogo obucheniia.

Changes in central nervous system of teenagers mastering miner occupations depended on insufficient physical activity and determined high prevalence of individuals with disharmonious psychic condition.

[An assessment of the mental status of miners exposed to the noise load]. / Otsenka psikhologicheskogo statusa gornorabochikh, podvergaiushchikhsia shumovoi nagruzki.

The use of psychological-and-diagnostic techniques ant tests designed to study the mental condition and to evaluate the efficiency of psychological adaptation will ensure an early detection of different disorders in the mental status of miners and a differentiation of the population according to their prevalence, which is of a great prognostication importance. The choice of the most informative indices of the miners' psychological status will make it possible to use them in evaluating the professional adaptability of young experts mastering the mining skills, which would maintain a high standard of health and labor longevity.