RESUMO
Morphologic and morphometric characteristics of the grouped lymphoid nodules (Peyer's patches) and of the small intestine lamina propria were studied in rats at the 19 prenatal and 1, 7, 14, 21, 90 postnatal days. The development of these structures was found to be heterochronic and fragmentary. The development of the individual components of the mucosal immune system was interrelated. The integration of the afferent and efferent limbs of the mucosal immune system with the processes of digestion and absorption, is regarded as its adaptation to the peculiarities of postnatal development of mammals and as the property of the functional system, maintaining the homeostasis of the internal milieu of the organism.
Assuntos
Envelhecimento/imunologia , Mucosa Intestinal/imunologia , Intestino Delgado/imunologia , Envelhecimento/fisiologia , Animais , Mucosa Intestinal/embriologia , Mucosa Intestinal/crescimento & desenvolvimento , Intestino Delgado/embriologia , Intestino Delgado/crescimento & desenvolvimento , Mucosa/embriologia , Mucosa/crescimento & desenvolvimento , Mucosa/imunologia , Nódulos Linfáticos Agregados/embriologia , Nódulos Linfáticos Agregados/crescimento & desenvolvimento , Nódulos Linfáticos Agregados/imunologia , RatosRESUMO
Using the quantitative analysis of mast cell number and granularity, some regularities of their age-associated dynamics were established. In suckling babies and in early childhood the mast cells are small and contain a moderate amount of secretory granules with no signs of degranulation. Henceforth they become larger and are functioning asynchronously. Mast cell number increases up to the age of 16 years. After 36 years mast cell prevalence and their secretory granule content are reduced.