ACCELERATED PROGRESSION OF DIABETIC RETINOPATHY IN A PATIENT WITH ACQUIRED LIPODYSTROPHY AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION.

PURPOSE: To report a case of bilateral proliferative diabetic retinopathy and lipemia retinalis in a patient with acquired lipodystrophy. METHODS: A retrospective case report. RESULTS: A 23-year-old woman with a diagnosis of acquired lipodystrophy was referred for ophthalmic evaluation. She had been diagnosed with acute lymphocytic leukemia at the age of 3 years and undergone hematopoietic stem cell transplantation. Best-corrected visual acuity was 20/20 in both eyes; however, funduscopy revealed bilateral diabetic retinopathy and lipemia retinalis, neither of which was apparent 2 years earlier. She had a glycated hemoglobin level of 9.6% and a triglyceride level of 7,394 mg/dL with creamy appearance of serum. Fluorescein angiography showed bilateral neovascularization. CONCLUSION: Accelerated progression of diabetic retinopathy in this case seemed to be associated with the onset of lipemia retinalis. We encourage continued ophthalmologic monitoring of patients who underwent hematopoietic stem cell transplantation in childhood for possible accelerated course of diabetic retinopathy.

Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan.

PURPOSE: To determine the baseline characteristics of patients with central retinal vein occlusion (CRVO) that were significantly associated with the best-corrected visual acuity (BCVA) at the initial examination. METHODS: This was a retrospective multicenter study using the medical records registered in 17 ophthalmological institutions in Japan. Patients with untreated CRVO (≥20-years-of-age) who were initially examined between January 2013 and December 2017 were studied. The patients' baseline factors that were significantly associated with the BCVA at the initial examination were determined by univariate and multivariate linear regression analyses. RESULTS: Data from 517 eyes of 517 patients were analyzed. Univariate analyses showed that an older age (r = 0.194, p < 0.001) and the right eye (r = -0.103, p < 0.019) were significantly associated with poorer BCVA at the initial visit. Multivariate analyses also showed that an older age (ß = 0.191, p < 0.001) and the right eye (ß = -0.089, p = 0.041) were significantly associated with poorer BCVA at the initial visit. CONCLUSIONS: The results indicate that an older age, a known strong factor, and the right eye were significantly associated with poorer BCVA at the initial visit to the hospital. These results suggest that functional and/or anatomical differences between the right and left eyes may be involved in these results.

[Influence of postoperative lens status on intraocular pressure and corneal endothelium following vitrectomy with silicone oil tamponade].

PURPOSE: To evaluate the influence of postoperative lens status on intraocular pressure elevation and corneal endothelial cell loss in patients who underwent pars plana vitrectomy with silicone oil injection for the management of complex retinal detachment. PATIENTS AND METHODS: The medical records of 80 eyes of 79 patients who underwent silicone oil removal were reviewed retrospectively. For analysis, eyes were divided by postoperative lens status into 2 groups: pseudophakic eyes (IOL group) and aphakic eyes(aphakic group). RESULTS: There was a significantly greater decrease in intraocular pressure after silicone oil removal in the aphakic group but not in the IOL group. As compared with the IOL group, the aphakic group showed a significant reduction in endothelial cell density at the time of silicone oil removal. CONCLUSION: Patients who underwent silicone oil injection with pseudophakic eyes may have a lower risk of intraocular pressure elevation and corneal endothelial cell loss than those with aphakic eyes.