Estimated gray matter volume rapidly changes after a short motor task.

Skill learning induces changes in estimates of gray matter volume (GMV) in the human brain, commonly detectable with magnetic resonance imaging (MRI). Rapid changes in GMV estimates while executing tasks may however confound between- and within-subject differences. Fluctuations in arterial blood flow are proposed to underlie this apparent task-related tissue plasticity. To test this hypothesis, we acquired multiple repetitions of structural T1-weighted and functional blood-oxygen level-dependent (BOLD) MRI measurements from 51 subjects performing a finger-tapping task (FTT; á 2 min) repeatedly for 30-60 min. Estimated GMV was decreased in motor regions during FTT compared with rest. Motor-related BOLD signal changes did not overlap nor correlate with GMV changes. Nearly simultaneous BOLD signals cannot fully explain task-induced changes in T1-weighted images. These sensitive and behavior-related GMV changes pose serious questions to reproducibility across studies, and morphological investigations during skill learning can also open new avenues on how to study rapid brain plasticity.

Computational investigation of left ventricular hemodynamics following bioprosthetic aortic and mitral valve replacement.

The left ventricle of the heart is a fundamental structure in the human cardiac system that pumps oxygenated blood into the systemic circulation. Several valvular conditions can cause the aortic and mitral valves associated with the left ventricle to become severely diseased and require replacement. However, the clinical outcomes of such operations, specifically the postoperative ventricular hemodynamics of replacing both valves, are not well understood. This work uses computational fluid-structure interaction (FSI) to develop an improved understanding of this effect by modeling a left ventricle with the aortic and mitral valves replaced with bioprostheses. We use a hybrid Arbitrary Lagrangian-Eulerian/immersogeometric framework to accommodate the analysis of cardiac hemodynamics and heart valve structural mechanics in a moving fluid domain. The motion of the endocardium is obtained from a cardiac biomechanics simulation and provided as an input to the proposed numerical framework. The results from the simulations in this work indicate that the replacement of the native mitral valve with a tri-radially symmetric bioprosthesis dramatically changes the ventricular hemodynamics. Most significantly, the vortical motion in the left ventricle is found to reverse direction after mitral valve replacement. This study demonstrates that the proposed computational FSI framework is capable of simulating complex multiphysics problems and can provide an in-depth understanding of the cardiac mechanics.

A framework for biomechanics simulations using four-chamber cardiac models.

Computational cardiac models have been extensively used to study different cardiac biomechanics; specifically, finite-element analysis has been one of the tools used to study the internal stresses and strains in the cardiac wall during the cardiac cycle. Cubic-Hermite finite element meshes have been used for simulating cardiac biomechanics due to their convergence characteristics and their ability to capture smooth geometries compactly-fewer elements are needed to build the cardiac geometry-compared to linear tetrahedral meshes. Such meshes have previously been used only with simple ventricular geometries with non-physiological boundary conditions due to challenges associated with creating cubic-Hermite meshes of the complex heart geometry. However, it is critical to accurately capture the different geometric characteristics of the heart and apply physiologically equivalent boundary conditions to replicate the in vivo heart motion. In this work, we created a four-chamber cardiac model utilizing cubic-Hermite elements and simulated a full cardiac cycle by coupling the 3D finite element model with a lumped circulation model. The myocardial fiber-orientations were interpolated within the mesh using the Log-Euclidean method to overcome the singularity associated with interpolation of orthogonal matrices. Physiologically equivalent rigid body constraints were applied to the nodes along the valve plane and the accuracy of the resulting simulations were validated using open source clinical data. We then simulated a complete cardiac cycle of a healthy heart and a heart with acute myocardial infarction. We compared the pumping functionality of the heart for both cases by calculating the ventricular work. We observed a 20% reduction in acute work done by the heart immediately after myocardial infarction. The myocardial wall displacements obtained from the four-chamber model are comparable to actual patient data, without requiring complicated non-physiological boundary conditions usually required in truncated ventricular heart models.

Fluid dynamics topics in bloodstain pattern analysis: comparative review and research opportunities.

This comparative review highlights the relationships between the disciplines of bloodstain pattern analysis (BPA) in forensics and that of fluid dynamics (FD) in the physical sciences. In both the BPA and FD communities, scientists study the motion and phase change of a liquid in contact with air, or with other liquids or solids. Five aspects of BPA related to FD are discussed: the physical forces driving the motion of blood as a fluid; the generation of the drops; their flight in the air; their impact on solid or liquid surfaces; and the production of stains. For each of these topics, the relevant literature from the BPA community and from the FD community is reviewed. Comments are provided on opportunities for joint BPA and FD research, and on the development of novel FD-based tools and methods for BPA. Also, the use of dimensionless numbers is proposed to inform BPA analyses.