RESUMO
Acute myelogenous leukemia (AML) secondary to acute lymphoblastic leukemia (ALL) in children is uncommon and usually occurs within 10 years of completing therapy for ALL. A variety of recurrent cytogenetic abnormalities have been described, suggesting significant biological heterogeneity. We report a case of highly refractory secondary AML with trisomy 10 and del(9q) occurring in an adolescent female 12 years after she was treated successfully for precursor B-cell ALL with chemotherapy only.
Assuntos
Cromossomos Humanos Par 10 , Cromossomos Humanos Par 9 , Leucemia Aguda Bifenotípica/genética , Leucemia Mieloide Aguda/genética , Trissomia , Adolescente , Pré-Escolar , Aberrações Cromossômicas , Bandeamento Cromossômico , Deleção Cromossômica , Citogenética , Diploide , Evolução Fatal , Feminino , Humanos , Cariotipagem , Leucemia Aguda Bifenotípica/patologia , Leucemia Mieloide Aguda/complicações , MetáfaseAssuntos
Febre de Causa Desconhecida/etiologia , Linfadenite Histiocítica Necrosante/complicações , Linfadenite Histiocítica Necrosante/diagnóstico , Linfonodos/patologia , Doenças Linfáticas/complicações , Biópsia por Agulha , Criança , Seguimentos , Linfadenite Histiocítica Necrosante/tratamento farmacológico , Humanos , Imuno-Histoquímica , Doenças Linfáticas/diagnóstico , Masculino , Prednisona/uso terapêutico , Medição de Risco , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
We describe a case of cutaneous T-cell lymphoma occurring in a 21-year-old male with Wolf-Hirschhorn syndrome (WHS) due to a chromosome 4p16.3 deletion. This is the first documented case report of malignancy occurring in an adult with WHS. We also review the literature regarding patients with WHS and the joint occurrence of malignancy and discuss genetic changes involving chromosome 4 which may have contributed to the genesis of our patient's lymphoma.