RESUMO
INTRODUCTION: Neurofibromatosis is a term used for two disorders: NF-1 and NF-2. NF-1 is Von Recklinghasusen's neurofibromatosis and comprises characteristic skin lesions (cafe au lait spots, intertriginous freckles, neurofibromatous skin tumors) and other congenital and hamartomatous bone, endocrine glands and central nervous system lesions. Its incidence is one in every 2500 to 3300 births. CASE REPORT: Two female patients, a 20 years old daughter and her mother 46 years of age were admitted to the Clinic of Dermatovenereology in Novi Sad due to appearance of many sessile and pedunculated neurofibromas, cafe au lait spots and freckles on their trunks, axillary and inguinal regions. Laboratory findings showed no abnormalities. Both of them were examined by many specialists. No systemic disturbances were established. The daughter was sent to plastic surgery for operative treatment. DISCUSSION: The clinical presentation of NF-1 is very variegated. Beside characteristic skin lesions, other clinical features include skeletal bony abnormalities, mental deficiency, seizures, neurofibromas of the spinal and cranial nerve roots, iris hamartomas, optic nerve gliomas, endocrine disorders, endocrine tissue tumors, other visceral tumors, etc. Some of these disorders can be life-threatening. Malignant transformations of the NF-1 lesions occur approximately in 5% of patients, most often as neurofibrosarcomas, Wilms' tumors, rhabdomyosarcomas or various forms of leukemias. CONCLUSION: We present familial cases of Von Recklingausen's neurofibromatosis without systemic abnormalities so far. The clinical course of this disease is unpredictable and a multidiscipline clinical assessment is necessary during whole life.
Assuntos
Neurofibromatose 1/genética , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neurofibromatose 1/diagnóstico , Neurofibromatose 1/patologia , LinhagemRESUMO
Squamous cell carcinoma is a morphologically heterogenous neoplasm of specific histologic entities involved in human papillomavirus infection. The condylomatous types of squamous cell vulvar carcinoma, caused by HPV-16, most often manifest as exophytic papillary tumors mimicking condylomas.
Assuntos
Neoplasias do Ânus/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Condiloma Acuminado/diagnóstico , Recidiva Local de Neoplasia/diagnóstico , Papillomaviridae/isolamento & purificação , Neoplasias Cutâneas/diagnóstico , Neoplasias Vulvares/diagnóstico , Abdome/cirurgia , Neoplasias do Ânus/patologia , Neoplasias do Ânus/cirurgia , Neoplasias do Ânus/virologia , Carcinoma de Células Escamosas/secundário , Carcinoma de Células Escamosas/cirurgia , Condiloma Acuminado/complicações , Condiloma Acuminado/patologia , Condiloma Acuminado/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Invasividade Neoplásica , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgia , Neoplasias Cutâneas/secundário , Neoplasias Cutâneas/cirurgia , Retalhos Cirúrgicos , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgia , Neoplasias Vulvares/virologiaRESUMO
The existing data bases - on the number and distribution of the injured are unfortunately unreliable and very poor. There is also a shortage of information needed in assessing human and financial aspect of the trauma as well as physical, social, economic and psychological circumstances under wich injuries have heppened. That is why the bases of all activities linked with solving the existing problems in traumatism in the traumawork of Trauma System presents epidemiological methods in the form of Trauma Register. Trauma Register is intended for creation of data base wich would identify, describe, quantity and quality injuries and traumatic deaths including even risk factors and it is expected to help in planning of the future health policy, volume and quality of preventive measures and activities wich would be useful for more accurate monitoring of preventive measures and acitivities wich would be useful for more accurate monitoring of preventive role in decreasing values of frequency of injuries and accidental deaths.