Indomethacin and meclofenamate do not alter ACTH and cortisol responses to corticotropin-releasing hormone (CRH) in normal subjects.

The responses of plasma ACTH and cortisol to CRH were studied in seven healthy subjects before and after three days treatment with indomethacin and meclofenamate. Both cyclooxygenase blockers elicited a reduction of plasma levels of stable metabolite of prostaglandin E2, but did not alter significantly ACTH and cortisol responses to CRH. The clinical implication of this study is that the short-term treatment with indomethacin and meclofenamate at the usual therapeutic doses does not alter release of ACTH and cortisol either under basal or stimulated condition.

[Catecholamine excretion in insulin-treated diabetic patients]. / Katecholaminausscheidung bei insulinbehandelten Diabetikern.

The urine excretion of the catecholamines adrenalin, noradrenalin and dopamine as well as the serum levels of cortisol and STH were determined with the aim to establish objective criteria for a "latent" hypoglycaemia in diabetics. The altogether 45 insulin-requiring diabetics had no hypoglycaemia (n = 28) and the decrease of blood sugar, respectively, occurred during the daytime (n = 6) or at night (n = 11). From the results no significance for the catecholamines as parameters of a hypoglycaemia that happened long ago can be derived. Deviation in the circadian rhythms of the cortisol levels in diabetics with hypoglycaemias need the securing by further investigations.