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Significance: For the development and routine characterization of optical devices used in medicine, tissue-equivalent phantoms mimicking a broad spectrum of human skin properties are indispensable. Aim: Our work aims to develop a tissue-equivalent phantom suitable for photoplethysmography applications. The phantom includes the optical and mechanical properties of the three uppermost human skin layers (dermis, epidermis, and hypodermis, each containing different types of blood vessels) plus the ability to mimic pulsation. Approach: While the mechanical properties of the polydimethylsiloxane base material are adjusted by different mixing ratios of a base and curing agent, the optical properties are tuned by adding titanium dioxide particles, India ink, and synthetic melanin in different concentrations. The layered structure of the phantom is realized using a doctor blade technique, and blood vessels are fabricated using molding wires of different diameters. The tissue-mimicking phantom is then integrated into an artificial circulatory system employing piezo-actuated double diaphragm pumps for testing. Results: The optical and mechanical properties of human skin were successfully replicated. The diameter of the artificial blood vessels is linearly dependent on pump actuation, and the time-dependent expansion profile of real pulse forms were mimicked. Conclusions: A tissue equivalent phantom suitable for the ex-vivo testing of opto-medical devices was demonstrated.
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Dispositivos Ópticos , Pele , Humanos , Pele/diagnóstico por imagem , Fotopletismografia , Imagens de Fantasmas , EpidermeRESUMO
BACKGROUND: Spectroscopic techniques are widely used for the non-destructive maturation and quality monitoring of different fruits. To develop new sensor devices for this purpose, knowing the optical properties of the agricultural sample is crucial for enabling the prediction of the interaction of the incident light with the fruit. RESULTS: In the present study, the optical properties of three different seedless grape varieties (ARRA15, Tawny and Melody/Blagratwo) were determined from 400 to 1000 nm using a UV-visible/near-infrared spectrometer with an integrating sphere and subsequent calculation of the absorption and scattering coefficients and the anisotropy factor using the inverse adding doubling method. The results indicate that the optical properties of different grape varieties have significant differences, especially in the visible wavelength region, whereas these are less distinct in the near-infrared range. Independent of grape variety, the grape berry skin has a higher scattering coefficient and scattering occurs predominantly in the forward direction. Based on the optical properties of the grape berries, a three-dimensional grape berry model is generated within OpticStudio (Zemax, LLC) for the different varieties that can be used in optical illumination simulations. The bulk scattering inside the fruit is modeled by the Henyey-Greenstein distribution. A comparison of the simulated values for the total transmission and the specular reflection determined experimentally shows that realistic optical grape models can be created within OpticStudio. CONCLUSION: Overall, the procedure for creating optical grape models presented here will be helpful for the development of optical applications used in pre- and post-harvest food quality monitoring. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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Vitis , Frutas/química , Simulação por Computador , Análise Espectral , Qualidade dos AlimentosRESUMO
Transparent ceramics like magnesium aluminate spinel (MAS) are considered the next step in material evolution showing unmatched mechanical, chemical and physical resistance combined with high optical transparency. Unfortunately, transparent ceramics are notoriously difficult to shape, especially on the microscale. Therefore, a thermoplastic MAS nanocomposite is developed that can be shaped by polymer injection molding at high speed and precision. The nanocomposite is converted to dense MAS by debinding, pre-sintering, and hot isostatic pressing yielding transparent ceramics with high optical transmission up to 84 % and high mechanical strength. A transparent macroscopic MAS components with wall thicknesses up to 4 mm as well as microstructured components with single micrometer resolution are shown. This work makes transparent MAS ceramics accessible to modern high-throughput polymer processing techniques for fast and cost-efficient manufacturing of macroscopic and microstructured components enabling a plethora of potential applications from optics and photonics, medicine to scratch and break-resistant transparent windows for consumer electronics.
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Cerâmica , Nanocompostos , PolímerosRESUMO
Glass is increasingly desired as a material for manufacturing complex microscopic geometries, from the micro-optics in compact consumer products to microfluidic systems for chemical synthesis and biological analyses. As the size, geometric, surface roughness, and mechanical strength requirements of glass evolve, conventional processing methods are challenged. We introduce microscale computed axial lithography (micro-CAL) of fused silica components, by tomographically illuminating a photopolymer-silica nanocomposite that is then sintered. We fabricated three-dimensional microfluidics with internal diameters of 150 micrometers, free-form micro-optical elements with a surface roughness of 6 nanometers, and complex high-strength trusses and lattice structures with minimum feature sizes of 50 micrometers. As a high-speed, layer-free digital light manufacturing process, micro-CAL can process nanocomposites with high solids content and high geometric freedom, enabling new device structures and applications.
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In recent years, additive manufacturing (AM) of glass has attracted great interest in academia and industry, yet it is still mostly limited to liquid nanocomposite-based approaches for stereolithography, two-photon polymerization, or direct ink writing. Melt-extrusion-based processes, such as fused deposition modeling (FDM), which will allow facile manufacturing of large thin-walled components or simple multimaterial printing processes, are so far inaccessible for AM of transparent fused silica glass. Here, melt-extrusion-based AM of transparent fused silica is introduced by FDM and fused feedstock deposition (FFD) using thermoplastic silica nanocomposites that are converted to transparent glass using debinding and sintering. This will enable printing of previously inaccessible glass structures like high-aspect-ratio (>480) vessels with wall thicknesses down to 250 µm, delicate parts including overhanging features using polymer support structures, as well as dual extrusion for multicolored glasses.