Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway.

Uncontrolled hyperuricemia often leads to the development of hyperuricemic nephropathy (HN), characterized by excessive inflammation and oxidative stress. Piperine, a cinnamic acid alkaloid, possesses various pharmacological activities, such as antioxidant and anti-inflammatory effects. In this study, we intended to investigate the protective effects of piperine on adenine and potassium oxonate-induced HN mice and a uric-acid-induced injury model in renal tubular epithelial cells (mRTECs). We observed that treatment with piperine for 3 weeks significantly reduced serum uric acid levels and reversed kidney function impairment in mice with HN. Piperine (5 µM) alleviated uric acid-induced damage in mRTECs. Moreover, piperine inhibited transporter expression and dose-dependently inhibited the activity of both transporters. The results revealed that piperine regulated the AKT/mTOR signaling pathway both in vivo and in vitro. Overall, piperine inhibits URAT1/GLUT9 and ameliorates HN by inhibiting the AKT/mTOR pathway, making it a promising candidate for patients with HN.

Insights into interfacial chemistry of Ni-rich cathodes and sulphide-based electrolytes in all-solid-state lithium batteries.

All-solid-state lithium batteries (ASSLBs) have attracted increasing attention recently because they are more safe and have higher energy densities than conventional lithium-ion batteries. In particular, ASSLBs composed of Ni-rich cathodes, sulphide-based solid-state electrolytes (SSEs) and lithium metal anodes have been regarded as the most competitive candidates. Ni-rich cathodes possess high operating potential, high specific energy and low cost, and sulphide-based SSEs have excellent ionic conductivity comparable to that of liquid electrolytes. However, severe parasitic reactions and chemo-mechanical issues hinder their practical application. Herein, the structure, ionic conductivity, chemical or electrochemical stability and mechanical property of sulphide-based SSEs are introduced. Critical interfacial problems between Ni-rich cathodes and sulphide-based SSEs, including chemical or electrochemical parasitic reactions, space charge layer effect, mechanical stress and contact loss, are summarised. The corresponding solutions including coating layer construction and structure design are expounded. Finally, the remaining challenges are discussed, and perspectives are outlined to provide guidelines for the future development of ASSLBs.

Carbon-free and binder-free Li-Al alloy anode enabling an all-solid-state Li-S battery with high energy and stability.

Incompatibility of electrolytes with Li anode impedes the application of solid-state batteries. Aluminum with appropriate potential, high-capacity, and electronic conductivity can alloy with Li spontaneously and is proposed herein as a carbon-free and binder-free anode of an all-solid-state Li-S battery (LSB). A biphasic lithiation reaction of Al with modest volume change was revealed by in situ characterization. The Li0.8Al alloy anode showed excellent compatibility toward the Li10GeP2S12 (LGPS) electrolyte, as verified by the steady Li0.8Al-LGPS-Li0.8Al cell operation for over 2500 hours at 0.5 mA cm-2. An all-solid-state LSB comprising Li0.8Al alloy anode and melting-coated S composite cathode functioned steadily for over 200 cycles with a capacity retention of 93.29%. Furthermore, a Li-S full cell with a low negative-to-positive ratio of 1.125 delivered a specific energy of 541 Wh kg-1. This work provides an applicable anode selection for all-solid-state LSBs and promotes their practical procedure.