RESUMO
Schistosomiasis is a parasitic disease that seriously endangers human health and affects socioeconomic developments. Artificial intelligence technology has been widely used in clinical medical sciences, including tumor screening, and electrocardiogram, imaging and pathological analyses, which has potential for precision control of schistosomiasis. Currently, artificial intelligence technology has been employed for clinical assessment of schistosomiasis-associated hepatic fibrosis and ectopic schistosomiasis, prognostic prediction of advanced schistosomiasis, automated identification of Oncomelania hupensis and Schistosoma japonicum eggs and miracidia, epidemiological surveillance of schistosomiasis, and drug discovery. This review summarizes the advances in the applications of artificial intelligence technology in the management of schistosomiasis and proposes the prospects for the use of artificial intelligence in schistosomiasis elimination.
Assuntos
Gastrópodes , Schistosoma japonicum , Esquistossomose , Humanos , Animais , Inteligência Artificial , Esquistossomose/diagnóstico , Esquistossomose/prevenção & controle , Descoberta de DrogasRESUMO
Lecithin was blended to improve the hydrophilicity and biocompatibility of bone graft containing poly(l-lactic acid) (PLLA). Solution blending and freeze drying were used to fabricate symmetrical scaffolds containing different percentages of lecithin (lecithin: PLLA = 0, 5, 10 wt%). Scanning electron microscopy showed that the scaffolds maintained the three-dimensional porous structure. A water uptake experiment proved the significant improvement of hydrophilicity of the blend scaffold. With the addition of lecithin, the compressive strength and compressive modulus decreased. When the weight ratio of lecithin to PLLA was up to 10%, the compressive strength was still more than the lower limit of natural cancellous bone. To test the biocompatibility of the scaffolds, cell culture in vitro and subcutaneous implantation in vivo were performed. MC3T3-E1 preosteoblastic cells were cultured on the scaffolds for 7 days. Methylthiazol tetrazolium assay and laser scanning confocal microscopy were used to exhibit proliferation and morphology of the cells. The subcutaneous implantation in rats tested inflammatory response to the scaffolds. The results proved the better biocompatibility and milder inflammatory reactions of the blend scaffold (lecithin: PLLA = 5%) compared with the scaffold without lecithin. The modified scaffold containing lecithin is promising for bone tissue engineering.
Assuntos
Substitutos Ósseos/administração & dosagem , Substitutos Ósseos/química , Transplante Ósseo/métodos , Proliferação de Células/efeitos dos fármacos , Ácido Láctico/administração & dosagem , Ácido Láctico/química , Lecitinas/administração & dosagem , Lecitinas/química , Polímeros/administração & dosagem , Polímeros/química , Células 3T3 , Animais , Interações Hidrofóbicas e Hidrofílicas , Teste de Materiais , Camundongos , Poliésteres , RatosRESUMO
This paper reports the normal values of dermatoglyphics parameters of seven minority nationalities in Yunnan Province which are Bai, Blang, Yi, Hui, Lisu, Nu and Jinuo. The test of difference signification and cluster analysis show different parameters in several nationalities and the greatest most remarkable difference between Jinou and other nationalities. Han is very different from several nationalities. In each nationality, the symmetry pattern of same name finger or area is highly unanimous, the symmetry between left and right does not show random combination.