Deployable vortex generators for low Reynolds numbers applications powered by cephalopods inspired artificial muscles.

This paper proposes deployable vortex generators (VGs) powered by twisted spiral artificial muscles (TSAMs). TSAMs take inspiration from cephalopods' papillae and can protrude out of plane upon electro-thermal actuation with an output strain of 2000% and an input voltage of 0.2 V/cm. Unlike passive VGs, designed for specific flow conditions, this technology can adjust to changes in flow conditions by overcoming the limitations of existing active flow control devices in terms of portability and power requirements. Our technology can deploy different VGs configurations on demand, and match a desired target configuration, optimized for a specific flow condition. Experiments were conducted in a wind tunnel using a NASA Langley Research Center LS (1)-0417 GA(W)-1 airfoil. Stall delays and lift increase have been demonstrated for different flow conditions, with Reynolds numbers between 100,000 and 140,000. These findings are promising for enhancing efficiency in small unmanned aerial vehicles operating at low Reynolds numbers.

Structure-Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin.

With the growing crisis of antimicrobial resistance, it is critical to continue to seek out new sources of novel antibiotics. This need has led to renewed interest in natural product antimicrobials, specifically antimicrobial peptides. Nonlytic antimicrobial peptides are highly promising due to their unique mechanisms of action. One such peptide is apidaecin (Api), which inhibits translation termination through stabilization of the quaternary complex of the ribosome-apidaecin-tRNA-release factor. Synthetic derivatives of apidaecin have been developed, but structure-guided modifications have yet to be considered. In this work, we have focused on modifying key residues in the Api sequence that are responsible for the interactions that stabilize the quaternary complex. We present one of the first examples of a highly modified Api peptide that maintains its antimicrobial activity and interaction with the translation complex. These findings establish a starting point for further structure-guided optimization of Api peptides.

Imaging of pediatric extragonadal pelvic soft tissue tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper.

The most common pediatric extragonadal pelvic cancers include germ cell tumors, sacrococcygeal teratomas, and rhabdomyosarcomas (arising from the urinary bladder, prostate, paratesticular tissues, vagina, uterus, and perineum). This paper describes the radiological and nuclear medicine features of these entities and provides consensus-based recommendations for the assessment at diagnosis, during, and after treatment.

Radiologic Evaluation of the Child with a Limp.

A child presenting with a limp can present a diagnostic challenge to pediatricians. Clinical presentation, age, and history all contribute to the initial differential diagnosis; however, imaging plays a key role in the ultimate diagnosis, and the correct imaging study is essential to save time and health care expenses. This article will present a few of the more common causes of a limp and the recently updated imaging recommendations from the American College of Radiology to aid in final diagnosis. [Pediatr Ann. 2020;49(9):e395-e402.].