Spinal Muscular Atrophy Hypotonia Detection Using Computer Vision and Artificial Intelligence.

This case-control study uses computer vision and artificial intelligence to develop a screening tool for detecting spinal muscular atrophy in infants.

Digital Assistive Technology: The Online Assistance for a Peaceful Driving in Automated and Connected Vehicles.

In line with the progressive development of digital technologies, this theoretical article is about the conception of a digital twin - based assistant to increase the serenity of the journey of the occupants of a connected car, automated or not. Its main functions are (i) to manage the Human (driver and/or passenger) - Machine (vehicle) Interaction, (ii) to inform the occupants and support decision-making by avoiding stressful situations. This is done by appropriate prevention and remediation. We advocate that the virtual assistant functions for being empathetic can be done by taking the user's point of view. Thanks to the knowledge about tasks, practices, needs and constraints, we describe how car-user's individual features can be used to get her digital twin description. Based on ontologies, this features model, providing assistance is then to simulate online the next steps of the task realization, informing about conditions, prerequisites, post-requites and subtasks to be fulfilled. Expected effects of this cognitive technology dedicated to personalized assistance are a decrease in stress, in frequency of incident and accident situations, according to a monitoring, as complete as possible, of the car-driver's conditions and situations dedicated to a serene driving.

Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis.

Changes in lymphocyte production patterns occurring across human ontogeny remain poorly defined. In this study, we demonstrate that human lymphopoiesis is supported by three waves of embryonic, fetal, and postnatal multi-lymphoid progenitors (MLPs) differing in CD7 and CD10 expression and their output of CD127-/+ early lymphoid progenitors (ELPs). In addition, our results reveal that, like the fetal-to-adult switch in erythropoiesis, transition to postnatal life coincides with a shift from multilineage to B lineage-biased lymphopoiesis and an increase in production of CD127+ ELPs, which persists until puberty. A further developmental transition is observed in elderly individuals whereby B cell differentiation bypasses the CD127+ compartment and branches directly from CD10+ MLPs. Functional analyses indicate that these changes are determined at the level of hematopoietic stem cells. These findings provide insights for understanding identity and function of human MLPs and the establishment and maintenance of adaptative immunity.

Bench testing of tracheostomy tube-related insults using an instrumented manikin.

PURPOSE: Choosing the right tracheal tube for the right patient is a daily preoccupation for intensivists and emergency physicians. Tracheal tubes can generate severe complications, which are chiefly due to the pressures applied by the tube to the trachea. We designed a bench study to assess the frequency of pressure levels likely to cause tracheal injury. METHODS: We tested the pressure applied on the trachea by 17 tube models of a given size range. To this end, we added a pressure sensor to the posterior tracheal wall of a standardized manikin. RESULTS: Only 2 of the 17 tubes generated pressures under the threshold likely to induce tracheal injury (30 mmHg/3.99 kPa). The force exerted on the posterior wall of the trachea varied widely across tube models. CONCLUSION: Most models of tracheal tubes resulted in forces applied to the trachea that are usually considered capable of causing tracheal tissue injury. LEVEL OF EVIDENCE: Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence: How common is the problem?: step 1; Is this diagnostic or monitoring test accurate? (Diagnosis) step 5; What will happen if we do not add a therapy? (Prognosis) n/a; Does this intervention help? (Treatment Benefits) step 5; What are the COMMON harms?(Treatment Harms) step 5; What are the RARE harms? (Treatment Harms) step 5; Is this (early detection) test worthwhile? (Screening) step 5.

U-Net Neural Network for Heartbeat Detection in Ballistocardiography.

Monitoring vital signs of neonates can be harmful and lead to developmental troubles. Ballistocardiography, a contactless heart rate monitoring method, has the potential to reduce this monitoring pain. However, signal processing is uneasy due to noise, inherent physiological variability and artifacts (e.g. respiratory amplitude modulation and body position shifts). We propose a new heartbeat detection method using neural networks to learn this variability. A U-Net model takes thirty-second-long records as inputs and acts like a nonlinear filter. For each record, it outputs the samples probabilities of belonging to IJK segments. A heartbeat detection algorithm finally detects heartbeats from those segments, based on a distance criterion. The U-Net has been trained on 30 healthy subjects and tested on 10 healthy subjects, from 8 to 74 years old. Heartbeats have been detected with 92% precision and 80% recall, with possible optimization in the future to achieve better performance.

Motor imagery development and proprioceptive integration: Which sensory reweighting during childhood?

It is widely accepted that motor imagery development during childhood may be due to refinement of internal models of action. At the same time, gradual improvement of predictive motor control in children may reflect an increasing ability to integrate the proprioceptive afferences with other sources of sensory information (especially vision). The current study investigated the extent to which motor imagery refinement observed between 5 and 9 years of age was related to the increasing ability to integrate proprioceptive afferences with vision and audition signals. To attain this goal, we compared motor imagery performances of 96 children (32 5-year-olds, 32 7-year-olds, and 32 9-year-olds) who received either visual and auditory inputs (VA condition) or visual, auditory, and proprioceptive inputs (VAP condition) during the imagery task. Motor imagery capacity was evaluated by means of mental chronometry paradigm based on a walking task. Our results revealed that correlations between overt and covert movements gradually increased across age in either the VA or VAP condition. Most important, in 5- and 7-year-olds, covert walking times were significantly longer than overt walking times in the VAP condition, whereas covert walking times were not different from actual walking times in the VA condition. In 9-year-olds, covert walking times were not different from overt walking times in either the VAP or VA condition. We suggest that motor imagery refinement during childhood can be partially related to the ability to integrate proprioceptive inputs with other sources of sensory information. Furthermore, our results shed light on the sensory content of motor images in children.

Rôle des afférences proprioceptives dans le développement de l'imagerie motrice chez l'enfant.

To which extent is motor imagery (MI) development, commonly observed between the ages of 5 and 9, related to the increasing ability to integrate proprioceptive afferences for the control of action? This question was addressed in a study evaluating MI performance of 108 children aged 5, 7 and 9 years old. A mental chronometry paradigm based on a walking task was used. Integration of proprioceptive information was evaluated by comparing MI performance when children held an external load (5 % of the children weight) to when they did not. Results revealed that the external load affected MI performances of the 5 year olds. In 7 years old, MI performances remained unchanged whether they held an external load or not. At 9 years, holding an external load improved MI performances. Taken together, these results reveal that MI development could be linked to proprioceptive acuity refinement during childhood. These results are discussed according to the relation between MI, proprioceptive development and development of internal models of action during childhood. (PsycINFO Database Record

"Are we ready for robots that care for us?" Attitudes and opinions of older adults toward socially assistive robots.

Socially Assistive Robots (SAR) may help improve care delivery at home for older adults with cognitive impairment and reduce the burden of informal caregivers. Examining the views of these stakeholders on SAR is fundamental in order to conceive acceptable and useful SAR for dementia care. This study investigated SAR acceptance among three groups of older adults living in the community: persons with Mild Cognitive Impairment, informal caregivers of persons with dementia, and healthy older adults. Different technology acceptance questions related to the robot and user characteristics, potential applications, feelings about technology, ethical issues, and barriers and facilitators for SAR adoption, were addressed in a mixed-method study. Participants (n = 25) completed a survey and took part in a focus group (n = 7). A functional robot prototype, a multimedia presentation, and some use-case scenarios provided a base for the discussion. Content analysis was carried out based on recorded material from focus groups. Results indicated that an accurate insight of influential factors for SAR acceptance could be gained by combining quantitative and qualitative methods. Participants acknowledged the potential benefits of SAR for supporting care at home for individuals with cognitive impairment. In all the three groups, intention to use SAR was found to be lower for the present time than that anticipated for the future. However, caregivers and persons with MCI had a higher perceived usefulness and intention to use SAR, at the present time, than healthy older adults, confirming that current needs are strongly related to technology acceptance and should influence SAR design. A key theme that emerged in this study was the importance of customizing SAR appearance, services, and social capabilities. Mismatch between needs and solutions offered by the robot, usability factors, and lack of experience with technology, were seen as the most important barriers for SAR adoption.

Active touch in late-preterm and early-term neonates.

An infant-controlled tactile habituation without visual control procedure was used to evaluate the ability of 32 late-preterm neonates (mean gestational age: 34 weeks) and 32 early-term neonates (mean gestational age: 38 weeks) to actively explore with hands objects varying in texture (smooth, granular). Holding time and Hand Pressure Frequency (HPF) were recorded. Holding time decreased as habituation progressed in both group of neonates. Holding time increased from habituation trials to test trials only in early-term neonates. A reaction to novelty was only observed in early-term neonates. During habituation, HPF remained unchanged in late-preterm infants whereas HPF decreased in early-term infants. HPF increased from habituation trials to test trials in early-term neonates and in late-preterm infants. However, reaction to novelty was only observed for early-term infants. The significance of these results is discussed in reference to brain maturation in preterm infants.

Motor imagery for walking: a comparison between cerebral palsy adolescents with hemiplegia and diplegia.

The goal of the study was to investigate whether motor imagery (MI) could be observed in cerebral palsy (CP) participants presenting a bilateral affected body side (diplegia) as it has been previously revealed in participants presenting a unilateral body affected sided (hemiplegia). MI capacity for walking was investigated in CP adolescents diagnosed with hemiplegia (n=10) or diplegia (n=10) and in adolescents with typical motor development (n=10). Participants were explicitly asked to imagine walking before and after actually walking toward a target located at 4 m and 8 m. Movement durations for executed and imagined trials were recorded. ANOVA and Pearson's correlation analyses revealed the existence of time invariance between executed and imagined movement durations for the control group and both groups of CP participants. However, results revealed that MI capacity in CP participants was observed for the short distance (4 m) but not for the long distance (8 m). Moreover, even for short distance, CP participants performed worse than typical adolescents. These results are discussed inline of recent researches suggesting that MI in CP participants may not depend on the side of the lesion.

Assessment of motor imagery in cerebral palsy via mental chronometry: the case of walking.

Recent studies show varying results on whether motor imagery capacity is compromised in individuals with cerebral palsy (CP). Motor imagery studies in children predominantly used the implicit hand laterality task. In this task participants judge the laterality of displayed hand stimuli. A more explicit way of studying motor imagery is mental chronometry. This paradigm is based on the comparison between the movement durations of actually performing a task and imagining the same task. The current study explored motor imagery capacity in CP by means of mental chronometry of a whole body task. Movement durations of 20 individuals with CP (mean age=13 years, SD=3.6) were recorded in two conditions: actual walking and imagined walking. Six unique trajectories were used that varied in difficulty via manipulation of walking distance and path width. We found no main effect of condition (actual walking versus imagining) on movement durations. Difficulty of the walking trajectory did affect movement durations. In general, this was expressed by an increase in movement durations with increasing difficulty of the task. No interaction between task difficulty and movement condition was found. Our results show that task difficulty has similar effects on movement durations for both actual walking and imagined walking. These results exemplify that the tested individuals were able to use motor imagery in an explicit task involving walking. Previous studies using the implicit hand laterality task showed varying results on motor imagery capacity in CP. We therefore conclude that motor imagery capacity is task dependent and that an explicit paradigm as the one used in this study may reveal the true motor imagery capacity. The implications of these findings for the use of motor imagery training are discussed.

Young children's mapping between arrays, number words, and digits.

This study investigates when young children develop the ability to map between three numerical representations: arrays, spoken number words, and digits. Children (3, 4, and 5 years old) had to map between the two directions (e.g., array-to-digit vs. digit-to-array) of each of these three representation pairs, with small (1-3) and large numbers (4-6). Five-year-olds were at ceiling in all tasks. Three-year-olds succeeded when mapping between arrays and number words for small numbers (but not large numbers), and failed when mapping between arrays and digits and between number words and digits. The main finding was that four-year-olds performed equally well when mapping between arrays and number words and when mapping between arrays and digits. However, they performed more poorly when mapping between number words and digits. Taken together, these results suggest that children first learn to map number words to arrays, then learn to map digits to arrays and finally map number words to digits. These findings highlight the importance of directly exploring when children acquire digits rather than assuming that they acquire digits directly from number words.

Haptic processing in newborns of depressed and nondepressed mothers.

This study was conducted to compare how newborns of depressed mothers and newborns of nondepressed mothers gather tactile information about texture. Spontaneous manual activity on objects with a smooth or rough texture was recorded in 20 newborns born of mothers with a high risk of depression or a low risk of depression. An important result of the present study is that texture-based modulation of hand-pressing frequency was observed in both neonates born of depressed mothers and neonates born of nondepressed mothers. Moreover, hand-pressing frequency did not depend on the pressure exerted on the object, since all neonates displayed comparable pressure on the held object. Lastly, the results revealed that newborns of depressed mothers held the rough object twice as long as newborns of nondepressed mothers. These results are analyzed in reference to deregulated biochemical functions in neonates born of mothers with a high risk of depression.

From armchair to wheelchair: how patients with a locked-in syndrome integrate bodily changes in experienced identity.

Different sort of people are interested in personal identity. Philosophers frequently ask what it takes to remain oneself. Caregivers imagine their patients' experience. But both philosophers and caregivers think from the armchair: they can only make assumptions about what it would be like to wake up with massive bodily changes. Patients with a locked-in syndrome (LIS) suffer a full body paralysis without cognitive impairment. They can tell us what it is like. Forty-four chronic LIS patients and 20 age-matched healthy medical professionals answered a 15-items questionnaire targeting: (A) global evaluation of identity, (B) body representation and (C) experienced meaning in life. In patients, self-reported identity was correlated with B and C. Patients differed with controls in C. These results suggest that the paralyzed body remains a strong component of patients' experienced identity, that patients can adjust to objectives changes perceived as meaningful and that caregivers fail in predicting patients' experience.

Kinaesthetic and visual perceptions of orientations.

In the present study we compare the kinaesthetic and visual perception of the vertical and horizontal orientations (subjective vertical and subjective horizontal) to determine whether the perception of cardinal orientations is amodal or modality-specific. The influence of methodological factors on the accuracy of perception is also investigated by varying the stimulus position as a function of its initial tilt (clockwise or counterclockwise) and its angle (22 degrees, 45 degrees, 67 degrees, and 90 degrees) in respect to its physical orientation. Ten participants estimated the vertical and horizontal orientations by repositioning a rod in the kinaesthetic condition or two luminous points, forming a 'virtual line' in the visual condition. Results within the visual modality replicated previous findings by showing that estimation of the physical orientations is very accurate regardless of the initial position of the virtual line. In contrast, the perception of orientation with the kinaesthetic modality was less accurate and systematically influenced by the angle between the initial position of the rod and the required orientation. The findings question the assumption that the subjective vertical is derived from an internal representation of gravity and highlight the necessity of taking into account methodological factors in studies on subjective orientations.

A hierarchical modeling approach of hippocampus local circuit.

The modeling and simulation of a realistic nervous tissue are difficult because of the number of implied cell types (neuronal and glial), the topology of the networks, and the various heterogeneous molecular mechanisms. The MTIP (Mathematical Theory of Integrative Physiology) is used as a new modeling approach based on a representation in terms of functional interactions and a formalism (S-Propagator) related to n-level field theory. This work presents the passage from a theoretical description of the biological system to a computing implementation in the general case. The specific case of the hippocampus is presented, as well as how a drug allows learning and memory improvement in the local circuit of the CA1 area of the hippocampus. This in silico result is used to experimentally predict the drug effect in vitro to confirm the accuracy of MTIP.

The emergence of motor imagery in children.

A total of 80 children (40 5-year-olds and 40 7-year-olds) took part in an experiment to evaluate their capacity to mentally evoke a motor image of their own displacement. Using a chronometry paradigm, movement duration was compared in a task where children were asked to move in order to take a puppet back to its home (actual) and to think about themselves executing the same action (virtual). Movement durations for actual and virtual displacements were obtained in two conditions, where either no information was provided about the weight of the puppet to be displaced (standard situation) or the puppet was described as being heavy (informed situation). A significant correlation between actual and virtual walking durations was observed for 7-year-olds in the informed condition. This result provides evidence for a motor imagery process emerging in 7-year-olds when children are required to think about themselves in action.

Weight perception in neonate infants.

A recent research revealed the capacity of the newborn to haptically detect, the weight of an object [12]. In this research, we tried to determine the means by which newborn infants, not having yet exploratory procedures, are able to treat this object property. We support the assumption that tactile perceptive capacities of the newborn infants derive from a fundamental property of the sensorimotor system: its primary variability. After a period of habituation with a heavy or light object, an object of new weight is presented (period test). Three parameters of the sensorimotor activity were analyzed during these two periods: holding times, amplitude of the pressure exerted on the object and frequency of the pressure. Analyses of these parameters demonstrate the neonate's capacity to discriminate objects weight.

Kinesthetic estimation of the main orientations from the upright and supine positions.

This work investigated the accuracy of the perception of the main orientations (i.e., vertical and horizontal orientations) with the kinesthetic modality--a modality not previously used in this field of research. To further dissociate the influence of the postural and physical verticals, two body positions were explored (supine and upright). Twenty-two blindfolded participants were asked to set, as accurately as possible, a rod to both physical orientations while assuming one of the two body positions. The horizontal was perceived more accurately than the vertical orientation in the upright position but not in the supine position. Essentially, there were no differences in the supine position because the adjustments to the physical vertical were much more accurate than they were in the upright position. The lower accuracy in the estimation of the vertical orientation observed in the upright position might be linked to the dynamics associated with the maintenance of posture.

Early integrative cognitive development in human infants.

This article argues that the multimodal processing of sensorial flows is a biological property of organisms. Already effective at birth, the multimodal processing of flows organizes the infant's environment and unifies his/her perception, permitting the perception of multimodal but unified objects. The multimodal processing of sensorial flows is also a setting event for self-perception because it allows the infant to resolve two crucial questions: what is the source of the flow and where is the action. Lastly the multimodal processing of sensorial flows identifies very early cognitive processes in newborn infants.