Low Diopter Phakic Implantable Collamer Lens: Refractive and Visual Outcomes in Low Myopia and Myopic Astigmatism.

Purpose: Nowadays the Implantable Collamer Lens (ICL - STAAR Surgical. Monrovia. CA) is a refractive surgical technique offered not only when laser corneal correction is not possible but also when the patient requires premium quality indexes and when dry eye is a concern. The use of ICL phakic lenses in low myopic patients is an emanate factor to study and analyze in order to determine treatment predictability and stability in such patients. In this paper, we conducted a 1-year follow-up study on patients with myopia below -3.5D implanted with ICL lenses. Methods: This was a retrospective analytical study that includes patients with phakic ICL implantation from 2 independent clinics with a minimum follow-up of 12 months. Visual acuity, refractive outcomes, vault, and intraocular pressure (IOP) were assessed at 1, 6 and 12 months. Results: Eighty-two eyes from 82 patients were included in this analysis. Mean spherical equivalent was -2.34 ± 0.82 (Range -5.50 to -1.00 D). Mean spherical implanted ICL power was -3.04 ± 0.78 D. In 25 eyes (30.5%) a Toric-ICL (TICL) was implanted with a mean TICL cylinder power of +1.64±0.64. Efficacy and security index remained stable for 12 months at 1.07 and 1.09, respectively. Mean vault at 12 months was 513.78 ± 262.87 µm and IOP was 15.63 ± 2.17 mmHg. Conclusion: Phakic Implantable Collamer Lens implantation in very low myopia is a predictable, stable, safe, and effective technique with high efficacy and security indexes. Low diopter Toric ICL is also an excellent option for refractive surgery in cases of low diopter astigmatism.

Large-scale preparation of (13) C-labeled 2-(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones.

We have developed large-scale efficient procedures for the conversion of commercially available [(13) C]- or [(2) H3 ,(13) C]methanol and (13) CO2 or (13) C-labeled bromoacetic acid to 2-(phenylthio)[1,2-(13) C2 ]-, [1-(13) C]-, and [2-(13) C]acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two-carbon labeling precursors. We have used the (13) C-isotopomers of 2-(phenylthio)acetic acid in the synthesis of (13) C-labeled acrylic acid, methacrylic acid, and trans-crotonic acid.