Korean research project on the integrated exposure assessment of hazardous substances for food safety.

OBJECTIVES: This survey was designed to conduct the first nationwide dietary exposure assessment on hazardous substances including the intakes of functional food and herbal medicine. In this paper, we introduced the survey design and the results of the dietary exposure status and internal exposure levels of lead (Pb), cadmium (Cd), and mercury (Hg). METHODS: We selected 4867 subjects of all ages throughout Korea. We conducted a food survey, dietary survey, biomonitoring, and health survey. RESULTS: Pb and Cd were the highest (median value) in the seaweed (94.2 µg/kg for Pb; 594 µg/kg for Cd), and Hg was the highest in the fish (46.4 µg/kg). The dietary exposure level (median value) of Pb was 0.14 µg/kg body weight (bw)/d, 0.18 µg/kg bw/d for Cd, and 0.07 µg/kg bw/d for Hg. Those with a blood Pb level of less than 5.00 µg/dL (US Centers for Disease Control and Prevention, reference value for those 1 to 5 years of age) were 99.0% of all the subjects. Those with a blood Cd level with less than 0.30 µg/L (German Federal Environmental Agency, reference value for non-smoking children) were 24.5%. For those with a blood Hg level with less than 5.00 µg/L (human biomonitoring I, references value for children and adults, German Federal Environmental Agency) was 81.0 % of all the subjects. CONCLUSIONS: The main dietary exposure of heavy metals occurs through food consumed in a large quantity and high frequency. The blood Hg level and dietary exposure level of Hg were both higher than those in the European Union.

The weather watch/warning system for stroke and asthma in South Korea.

Weather watch/warning systems have been established for human health outcomes. Our study aims to develop and demonstrate a weather watch/warning system for asthma and stroke within the whole of South Korea, using a stratified regression approach. We converted claim-based health insurance data covering almost all medical claims for the only health insurance system in Korea for asthma and stroke from 1996-2003 into personalized disease episode data, and combined them with meteorological data. We utilized a step-wise regression method using factors extracted from the meteorological data to develop stratified models for six (stroke) and nine (asthma) regional and day-of-week strata. Validation studies showed that the actual number of hospitalizations in 2003 increased according to the three-leveled predictions (levels I, II, and III) from the model based on the 1996-2002 data. This system is accessible via the internet (http://industry.kma.go.kr/APP/sub_APP15_H01.htm) at the Korean Meteorological Administration website.