[Bilateral Wilm's tumor in the fetus]. / Tumeur de Wilms bilatérale chez le foetus.

The author reports a case of Wilms' tumor in a stillborn fetus and emphasizes the extreme rarity of this diagnosis in fetus and at birth despite monitoring pregnancy frequent sonography. There is no report of in utero ultrasound diagnosis of Wilms' tumor. Wilms' tumor develops from nephrogenic blastema rests which usually disappear after 34 weeks of gestation. Pediatric autopsies show that blastematous foci may persist after birth without necessarily forming nephroblastomas. Their frequency is one hundred times higher than that of nephroblastomas although they are often associated. Wilms' tumors are hereditary and more frequent in patients with congenital malformations related to genetic disorders. Because of therapeutic progress the diagnosis should be made very early particularly in high risk patients using sonography during pregnancy despite problems of interpretation and soon after birth.

Circulating gastrin, endocrine cells, histamine content, and histidine decarboxylase activity in atrophic gastritis.

Thirty-five patients with fundic atrophic gastritis and achlorhydria were classified in two groups according to the presence or absence of fundic argyrophil, mostly enterochromaffinlike cell hyperplasia. Among the biologic and histologic parameters studied, the hyperplasic group differed only by a circulating hypergastrinemia and an antral G-cell hyperplasia. The histamine content, the histidine decarboxylase activity, and the mast cell number of fundic biopsies were determined in 10 controls, 16 of the preceding patients (11 with and 5 without fundic argyrophil-cell hyperplasia), and 5 patients with fundic atrophic gastritis and neither achlorhydria nor hyperplasia. Histamine content and histidine decarboxylase activity were increased only in the hyperplasic group despite an unchanged mast cell number. For all fundic biopsies the argyrophil-cell density was positively related to the histamine content. Finally, the argyrophil-cell hyperplasia occurring in fundic atrophic gastritis with achlorhydria is associated not with the gastritis intensity, as assessed by histologic and secretory criteria, but with a circulating hypergastrinemia and an increase of both fundic histamine content and histidine decarboxylase activity.

[Extra-osseous mandibular ameloblastoma]. / Améloblastome mandibulaire extra-osseux.

Gingival ameloblastoma is a rare odontogenic tumor which shares the same histology as endo-osseous ameloblastoma but from which it differs in terms of its course by the absence of "local malignancy". There would appear to be two probable origins concerning this lesion: Serre debris and the epithelium of the gingival mucosa. However, the etiopathogenesis remains controversial, raising problems of pathological distinction from gingival basal cell carcinoma.

Ovarian sex cord tumor with annular tubules: an ultrastructural study.

We report the light- and electron-microscopic features of a case of sex cord tumor with annular tubules (SCTAT) in a 15-year-old girl. There was no Peutz-Jeghers syndrome (PJS). The tumor was unilateral, 6 cm in diameter, and encapsulated. Optically, the tumor was composed of cellular nests with tubules and hyaline bodies. There was no cytologic evidence of malignancy. Ultrastructural study revealed that the tumor cells were epithelial, with numerous tonofilaments connected to well-formed desmosomes, but neither Charcot-Böttcher crystalloids or filaments nor Reinke crystals were found. The hyaline bodies were composed of packed basement membranes and cellular debris secondary to cellular necrosis, and resembled Call-Exner bodies. There was no true lumen formation. SCTAT showed granulosa cell differentiation and, to a lesser extent, Sertoli cell differentiation. The value of dark cells as evidence of stromal cell origin is questionable, since they might represent metabolic hyperactive cells. We suggest that SCTAT not associated with PJS is a form of granulosa cell tumor, and when associated with PJS is a form of hamartoma.

[Polycystic renal disease and bilateral renal cancer]. / Maladie polykystique rénale et cancer rénal bilatéral.

The authors report a case of polycystic kidneys complicated by bilateral renal hypernephroma. This association has been rarely described and is probably frequently unrecognized because of the diagnostic difficulties. Angiography should be performed in all doubtful cases in order to obtain an early diagnosis so that the patients can benefit from modern therapeutic techniques. Polycystic kidneys is a familial hereditary disease capable, like other genetic diseases, of malignant transformation. Clinically undiagnosed partial forms of the disease can be the origin of certain cases of apparently primary renal cancer.

[Gliomas of the uterus. Apropos of 3 cases and review of the literature]. / "Gliomes" de l'utérus. A propos de trois cas et revue de la littérature.

We report three cases of uterine gliomas in young women with a past history of pregnancies and abortions. A survey of the literature revealed that the published cases also concerned young women with the identical gynecological history. The general belief is that the cause of uterine gliomas is the transplanting of fetal nervous tissue during local manipulations in early abortions. Increased numbers of abortions should lead to a higher frequency of such tumors. Transplanted embryonic glial tissue is viable at the beginning of pregnancy and provokes only a weak immunologic rejection. These tumors are benign and no case of transformation into glioblastomas has been reported.

[Cervical tuberculous adenitis in the adult. Diagnostic, therapeutic considerations apropos of 27 cases]. / Adénite tuberculeuse cervicale de l'adulte. Réflexions diagnostiques, thérapeutiques à propos de 27 cas.

The authors review 27 cases of cervical tuberculosis in the adult, complete and homogeneous and essentially describe their experience concerning positive diagnostic factors as well as their therapeutic approach. Considering the results obtained, they favour early surgical treatment ranging from simple adenectomy to complete and conservative cellulo-lympho-adenectomy which is the essential treatment of choice in multi-nodal forms. This surgical attitude makes possible to considerably shorten the duration of the local course by eliminating recurrences but on the essential condition that it is accompanied by prolonged medical treatment consisting of a triple association of major anti-tuberculous drugs.

[Morphologic manifestations of Waldenström's disease]. / Les expressions morphologiques de la maladie de Waldenström

The authors describe the various cytological and pathological lesions found in lymph node, spleen, bone marrow and liver in Waldenströms macroglobulinemia. The significance of the discovery of PAS positive intranuclear vacuoles is discussed. The findings are completed by a description of the results obtained in immunofluorescence and under the electron microscope. Unusual forms and the differential pathological diagnosis are then discussed.

[Unusual association of a papillary cystadenoma and a mixed tumor of the parotid]. / Association exceptionnelle d'un cystadénome papillaire et d'une tumeur mixte de la parotide

The authors describe the exceptional association within the same parotid gland of two oncologically different tumours. This provides them with material for discussion concerning the value of pre- and per-operative histological tests and leads them to put in a plea for total parotidectomy leaving the facial nerve intact.