RESUMO
Our hypothesis was that post-yield mechanical behavior of compact bone material in compression, defined as the stress, strain, or energy absorbed between 0.2% strain-offset and the point of maximum stress, is correlated with material density, modulus, strength, histomorphometric evidence of remodeling, and post-failure gross specimen morphology. Post-yield behavior of compact bone material from the third metacarpal bone of 10 horses, ages 5 months to 20 years, was investigated using single-load compression-to-failure. The post-yield stress, strain, and absorbed energy were compared with the compressive elastic modulus, yield stress, ash density. post-failure macroscopic appearance of the specimen, and histologic evidence of remodeling. High values of elastic modulus, yield stress, and ash density were associated with low values of post-yield mechanical properties (stress, strain, and absorbed energy). Macroscopic post-failure morphology was associated with post-yield mechanical behavior, in that specimens displaying fractures were associated with lower post-yield mechanical properties, and that those without evidence of frank fracture were associated with higher post-yield mechanical properties. Microscopic evidence of remodeling activity was associated with high post-yield mechanical properties, but not with gross post-failure morphology. There was an abrupt change from relatively high values to extremely low values of post-yield mechanical properties at intermediate levels of ash density. This feature may serve as a functional tipper limit to the maximization of bone material stiffness and strength.
Assuntos
Metacarpo/fisiologia , Animais , Fenômenos Biomecânicos , Densidade Óssea , Remodelação Óssea , Força Compressiva , Elasticidade , Fraturas Ósseas/fisiopatologia , Cavalos , Metacarpo/lesões , Metacarpo/patologia , Metacarpo/fisiopatologia , Minerais/metabolismo , Estresse MecânicoRESUMO
A 7-month-old female llama was examined because of chronic otitis media and externa of 7 months' duration. Radiographically, the tympanic bullae appeared thicker than normal, and the ventral borders were poorly defined; the left external acoustic meatus (ear canal) appeared to be narrower than the right. The llama was treated with penicillin, and the ear canals were lavaged daily. Contrast radiography was performed on day 15 to determine the shape and size of the ear canals and evaluate the integrity of the tympanic membranes. Contrast medium was visible radiographically in the left tympanic bulla, indicating that the left tympanic membrane was ruptured, but the right tympanic membrane appeared to be intact. The left ear canal was narrower than the right, and the bony ear canals had a well-defined sigmoid shape. The right ear improved with medial treatment alone, but the left ear did not. Therefore, lateral ear canal resection was performed. After surgery, however, exudate was still evident in the left ear canal, and the llama became more lethargic and more reluctant to eat. Lateral bulla osteotomy was attempted, but no purulent material was obtained, and curettage of the bulla resulted in hemorrhage. Because of this and because of the llama's poor physical condition, a decision was made to euthanatize the llama. The sigmoid shape of the bony ear canal and the multicompartmental nature of the tympanic bulla make surgical treatment of otitis media and externa in llamas difficult. Further study of surgical treatments for otitis media in llamas is needed.
Assuntos
Camelídeos Americanos , Orelha/patologia , Otite Média Supurativa/veterinária , Animais , Meios de Contraste , Meato Acústico Externo/diagnóstico por imagem , Feminino , Otite Externa/diagnóstico , Otite Externa/terapia , Otite Externa/veterinária , Otite Média Supurativa/diagnóstico , Otite Média Supurativa/terapia , Radiografia , Irrigação Terapêutica/veterináriaRESUMO
A 14-year-old 61.7-kg (136-lb) alpaca was examined for colic of 24 hours' duration. An exploratory celiotomy was performed because of lack of response to medical treatment and ultrasonography revealed an abnormally large amount of free fluid in the peritoneal cavity. Exploration of the abdomen revealed a 20-cm diameter mass, consisting of most of the ascending colon. The spiral colon was thick and edemetous, and it was decided to resect the spiral colon. Following a few complications, the alpaca was discharged 17 days after surgery. Colic in camelids is considered a severe problem because clinical signs are subtle and often not recognized until the condition is untreatable. Camelids are reported to be stoic animals, and may have few signs of pain despite severe abdominal disease. Alpacas with signs of abdominal pain should undergo early and complete physical, laboratory, and diagnostic imaging evaluations. Rapid identification of the need for surgery is vital for a successful outcome.
Assuntos
Camelídeos Americanos , Cólica/veterinária , Doenças do Colo/veterinária , Animais , Colectomia/veterinária , Cólica/etiologia , Doenças do Colo/diagnóstico , Doenças do Colo/terapia , Hidratação/veterinária , Anormalidade Torcional/diagnóstico , Anormalidade Torcional/terapia , Anormalidade Torcional/veterináriaAssuntos
Cistos Ósseos/veterinária , Fêmur , Doenças dos Cavalos/diagnóstico por imagem , Coxeadura Animal/diagnóstico por imagem , Tíbia , Animais , Cistos Ósseos/complicações , Cistos Ósseos/diagnóstico por imagem , Doenças dos Cavalos/etiologia , Cavalos , Coxeadura Animal/etiologia , RadiografiaRESUMO
OBJECTIVE: To describe the anatomy of the sternum in llamas, define the surgical approach to the sternum for collection of cancellous bone graft tissue, and compare the histologic appearance of graft tissue obtained from the sternum with that obtained from the proximal portion of the tibia. DESIGN: Prospective study. ANIMALS: 12 llamas, 3 to 19 years old, that had been submitted for necropsy. PROCEDURE: Radiographs were taken of the sternum and left tibia of the llamas. Measurements of the sternum were determined from the radiographs and adjusted for magnification. Sternebrae volumes were estimated from these measurements. Anatomic dissections to the center of the fourth sternebra and the proximal portion of the tibia were made, and a surgical approach to the sternum was developed. Cancellous graft tissue was obtained from each site and submitted for histologic evaluation. RESULTS: Sternebrae 3, 4, and 5 were significantly larger in volume than the other sternebrae. The ventral aspect of the fourth sternebra was readily accessed for removal of graft tissue by making a 6-cm-long ventral midline incision centered 17 cm craniad to the xipnoid. Mean soft tissue thickness overlying the ventral aspect of the fourth sternebra was 3.1 cm. More tissue was obtained from the sternal (mean, 9.11 g) than from the tibial (mean, 5.16 g) sites. Sternal graft tissue consisted of trabecular bone spicules with predominantly hematopoietic marrow, whereas tibial tissue consisted of trabecular bone spicules with only fatty marrow. CONCLUSIONS AND CLINICAL RELEVANCE: The fourth sternebra in llamas is readily accessible for obtaining autogenous cancellous bone graft tissue that consists of predominantly hematopoietic marrow.
Assuntos
Transplante Ósseo/veterinária , Camelídeos Americanos/anatomia & histologia , Esterno/anatomia & histologia , Tíbia/anatomia & histologia , Animais , Transplante Ósseo/fisiologia , Camelídeos Americanos/cirurgia , Histocitoquímica , Estudos Prospectivos , Radiografia , Esterno/diagnóstico por imagem , Esterno/cirurgia , Tíbia/diagnóstico por imagem , Tíbia/cirurgia , Transplante Autólogo/veterináriaRESUMO
This study sought to determine if extensive trimming of the front hooves of foals results in a higher incidence of palmar process fractures compared to untrimmed foals, and to characterise the clinical course of foals with palmar process fractures with physical findings, hoof measurements and radiography. Twenty foals age 4-8 weeks of multiple breeds were examined every 2 weeks over a 12 week period. Ten foals had both front hooves extensively trimmed every 4 weeks, while 10 foals remained untrimmed. Palmar process fractures occurred in 4 trimmed and 3 untrimmed foals. Four foals with fractures had brief lameness (Grades I-II/V) and hoof tester sensitivity was found inconsistently with fractures. All foals with fractures were sound at the end of the study. Fractures healed based on radiographic evaluations in an average of 8.4 weeks. Two of 3 foals with fractures developed club-footed conformation. None of the measured hoof parameters significantly differed between foals with and without fractures. We conclude that extensive trimming of the heels did not appear to affect the occurrence of palmar process fractures in this group of foals.
Assuntos
Fraturas Ósseas/veterinária , Casco e Garras/lesões , Casco e Garras/cirurgia , Cavalos/lesões , Cavalos/cirurgia , Dedos do Pé/lesões , Animais , Peso Corporal , Feminino , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/prevenção & controle , Casco e Garras/diagnóstico por imagem , Cavalos/anatomia & histologia , Modelos Lineares , Masculino , Radiografia , Dedos do Pé/diagnóstico por imagemRESUMO
The purpose of this study was to assess cortical and cancellous bone responses to unilateral limb immobilization and, subsequently, to remobilization with exercise, in a young adult canine model. Right forelimbs of 14 1-2-year old mongrel dogs were immobilized in a non-weight-bearing position by a bandage for 16 weeks. Six control dogs were untreated. At 16 weeks, seven immobilized and three control dogs were euthanized. The remaining seven immobilized dogs began a recovery protocol consisting of 16 weeks of kennel confinement (without the right forelimb bandaged) followed by 16 weeks of treadmill exercise conducted three times per week. These seven dogs and three control dogs were euthanized at 48 weeks. Bone mineral density of the proximal radii was determined with dual-energy X-ray absorptiometry and humeral middiaphyseal cross-sectional areas were determined with computed tomography. Humeri were tested in cranio-caudal three-point bending to failure. Cancellous bone cores from the lateral humeral condyles had wet apparent density determined and were tested to failure in compression. Mechanical properties, bone density, and cross-sectional areas were compared between immobilized (right forelimb), contralateral weight bearing (left forelimb), and control forelimbs with Kruskal-Wallis and post hoc tests. At 16 weeks, bone mineral density, cortical load, yield, and stiffness as well as cancellous bone failure stress, yield stress, and modulus were significantly lower (p < 0.02) for immobilized limbs than control limbs. Immobilized limb cancellous bone mechanical properties were 28%-74% of control values, and cortical bone mechanical properties were 71%-98% of control values. After 32 weeks of remobilization, cortical and cancellous bone mechanical properties were not different from control values except that cortical bone failure stress and modulus were significantly higher (p < 0.01) between remobilized and control limbs. In summary, 16 weeks of forelimb immobilization was associated with significantly lower mechanical properties, and with greater differences in cancellous than cortical bone properties. Mechanical properties were not different from control values after 32 weeks of recovery that included 16 weeks of treadmill exercise.
Assuntos
Densidade Óssea/fisiologia , Condicionamento Físico Animal , Rádio (Anatomia)/fisiologia , Absorciometria de Fóton , Análise de Variância , Animais , Fenômenos Biomecânicos , Cães , Extremidades , Feminino , Imobilização , Rádio (Anatomia)/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Suporte de CargaRESUMO
The purpose of this experiment was to study changes in bone mass, structure, and turnover in the canine forelimb after unilateral immobilization and recovery. The right forelimbs of 14 adult mongrel dogs were immobilized for 16 weeks. Six dogs served as controls. Seven immobilized and three control dogs were euthanized at the end of the immobilization period. Recovery consisted of 16 weeks of kennel confinement followed by 16 weeks of treadmill exercise. Seven once-immobilized and three control dogs were euthanized at the end of the recovery period. Bone mineral density of both the proximal (PBMD) and central (CBMD) radius was determined by dual X-ray absorptiometry. Standard histomorphometric endpoints for bone mass and turnover were determined in the cancellous bone of the proximal radius. After immobilization, PBMD, CBMD, and trabecular thickness were lower in the immobilized limb than in either the contralateral or control limbs (P < 0.05). Only CBMD remained significantly lower (P < 0.05) after recovery. At the end of immobilization, bone formation endpoints were significantly higher in the immobilized limb than both the contralateral and control limbs. Bone turnover was also significantly lower in the contralateral limb than in the immobilized and control limbs. After recovery, all differences in bone turnover had resolved. Immobilization of 16 weeks duration caused an elevation in cancellous bone formation rate and reduced bone density in both cortical and cancellous bone. After 32 weeks of recovery, turnover abnormalities disappeared, cancellous bone normalized, but cortical bone mass remained low. Recovery of cortical bone from immobilization takes longer than recovery of cancellous bone.
Assuntos
Densidade Óssea , Remodelação Óssea , Osso e Ossos/fisiopatologia , Extremidades/fisiopatologia , Imobilização/fisiologia , Animais , CãesRESUMO
Diagnosis and treatment of diseases of the foot, infectious arthritis, angular limb deformities, patellar luxation, tendon contracture and injuries, and fractures encountered in sheep, goats, llamas, and deer are reviewed. These species share similar orthopedic problems to cattle, but management conditions, particularly for pet animals, may place special demands on the veterinarian treating these disease conditions. The mild temperament and relatively small body size of these animals make them excellent candidates for treatment of orthopedic problems often not amenable to practical treatment in larger or more fractious animals.
Assuntos
Artrite Infecciosa/veterinária , Deformidades do Pé/veterinária , Doenças do Pé/veterinária , Fraturas Ósseas/veterinária , Deformidades Congênitas dos Membros , Ruminantes , Animais , Artrite Infecciosa/diagnóstico por imagem , Artrite Infecciosa/cirurgia , Camelídeos Americanos , Cervos , Feminino , Deformidades do Pé/diagnóstico por imagem , Deformidades do Pé/cirurgia , Doenças do Pé/diagnóstico por imagem , Doenças do Pé/cirurgia , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/cirurgia , Cabras , Luxações Articulares/diagnóstico por imagem , Luxações Articulares/cirurgia , Luxações Articulares/veterinária , Masculino , Radiografia , OvinosRESUMO
The purpose of this study was to investigate the relationships between data obtained from quantitative computed tomography and mechanical properties in the equine metacarpus, as measured in vitro in bone specimens. Three hundred and fifty-five bone specimens from the metacarpi of 10 horses were machined into right cylinders aligned with the long axis of the bone. A computed tomographic scan of the specimens, along with a Cann-Genant K2HPO4 calibration standard, was obtained. The specimens then were compressed to failure, and the elastic modulus, yield stress, yield strain, strain energy density at yield, ultimate stress, ultimate strain, and strain energy density at ultimate failure were calculated. The specimens were dried and ashed. Quantitative computed tomography-derived K2HPO4 equivalent density proved to be an excellent estimator (r2 > 0.9) of elastic modulus, yield stress, ultimate stress, wet density, dry density, and ash density; a moderately good estimator (0.4 < r2 < 0.9) of strain energy density at yield and at ultimate failure; and a poor estimator (r2 < 0.2) of yield strain and ultimate strain. It was concluded that the relationships between quantitative computed tomography data and mechanical properties of the equine metacarpus were strong enough to justify the use of these data in automated finite element modeling.
Assuntos
Cavalos/fisiologia , Metacarpo/diagnóstico por imagem , Metacarpo/fisiologia , Tomografia Computadorizada por Raios X , Animais , Fenômenos Biomecânicos , Densidade Óssea , Feminino , Masculino , Metacarpo/química , Fosfatos/análise , Compostos de Potássio/análise , Análise de RegressãoRESUMO
The distal phalanx and metacarpal physis of both forelimbs of 32 Thoroughbred foals 3-32 weeks of age were radiographed to identify those limbs with osseous bodies at a palmar process (PP) of the distal phalanx. Osseous bodies (ossicles) were identified radiographically in 19% of the foals. Sixteen of the 32 foals were selected for microradiographic and histological evaluation: 6 foals with radiographic evidence of ossicles and 10 foals without. Fourteen ossicles of the PP were observed radiographically. Ossicles were either a triangular bone fragment at the palmar aspect of the distal angle of the PP, or an oblong bone fragment separated from P3 by a radiolucent line extending 1-3 cm from the incisure of the PP to the solar margin. One foal had radiographic evidence of bilateral distal metacarpal physitis. Seventeen of 35 PPs examined microradiographically were considered normal, in that the dorsal and solar cortices were thin with trabecular bone orientated parallel to the cortical surfaces, and there was a depression in the dorsal cortical surface (i.e. parietal sulcus). Abnormal microradiographic findings in the other 18 PPs included a fracture line extending from the dorsal cortical surfaces and trabecular bridging of the fracture gap. The fracture line was often continuous with the parietal sulcus. Microradiographic evidence of a fracture was found in 75% of foals evaluated. Normal histological findings in 16 PPs included thin dorsal and solar cortices with trabeculae orientated parallel to the cortical surfaces, parallel-fibred dense connective tissue attachments of the deep digital flexor tendon to the solar cortical surfaces, and a neurovascular bundle associated with the parietal sulcus.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Fraturas Ósseas/veterinária , Casco e Garras/anatomia & histologia , Cavalos/anatomia & histologia , Animais , Feminino , Membro Anterior , Consolidação da Fratura , Fraturas Ósseas/diagnóstico por imagem , Casco e Garras/diagnóstico por imagem , Casco e Garras/lesões , Casco e Garras/patologia , Cavalos/lesões , Masculino , Microrradiografia/veterináriaRESUMO
Female rhesus monkeys were fed a commercial monkey diet and given selenium (Se) as either selenite or selenomethionine (SeMet) in the drinking water for 11 mo. Muscle and liver biopsies were taken initially and at the end of the experiment for determination of Se levels and glutathione peroxidase (GPX) activity. Blood was collected at monthly to bimonthly intervals, and the plasma and erythrocytes were subjected to gel filtration to determine the distribution of Se among proteins of various molecular weights. At the end of the experiment, there was significantly more Se in liver, muscle and hair from the monkeys given SeMet than in tissues from those given selenite, but there were no differences in liver or muscle GPX activity between the two treatment groups. The erythrocyte and plasma Se levels were significantly higher in the monkeys given SeMet than in those receiving selenite, but there were no differences in the GPX levels between these groups. About 68% of erythrocyte Se was associated with GPX in monkeys given selenite whereas only 34% was associated with GPX in those administered SeMet. The correlation coefficient for blood Se level and erythrocyte GPX activity was 0.92 in monkeys given selenite but only 0.37 in those given SeMet. Gel filtration of plasma revealed only one Se peak for plasma from the monkeys given selenite but at least two major Se peaks for plasma from monkeys receiving SeMet. The possible implications of these results for humans are discussed, including the reasons for poor correlations of GPX activity and blood Se levels.
Assuntos
Macaca mulatta/metabolismo , Macaca/metabolismo , Selênio/metabolismo , Selenometionina/metabolismo , Animais , Biópsia/veterinária , Cromatografia em Gel , Ingestão de Líquidos , Eritrócitos/análise , Feminino , Glutationa Peroxidase/análise , Cabelo/análise , Fígado/análise , Fígado/enzimologia , Músculos/análise , Músculos/enzimologia , Ácido Selenioso , Selênio/análise , Selênio/sangueRESUMO
Transfixation pinning with fiberglass casting is an effective and adaptable method of longbone fracture fixation in llamas and small ruminants. Treatment of fractures in 7 limbs of 4 llamas and 2 small ruminants with this technique are described. Steinmann pins are placed transcortically proximal, and if necessary, distal to the fracture. The pin ends and limb are encased in fiberglass cast material. The cast is strong enough in animals of this size to eliminate the need for external frames or connecting bars. Severely comminuted fractures and fractures near joints are especially suited to fixation with this technique. Complications encountered in these cases included loosening of pins and one delayed union. All fractures healed to permit full use of the limb.
Assuntos
Artiodáctilos/lesões , Pinos Ortopédicos/veterinária , Camelídeos Americanos/lesões , Moldes Cirúrgicos/veterinária , Fixação de Fratura/veterinária , Ruminantes/lesões , Animais , Bovinos/lesões , Feminino , Vidro , Masculino , Ovinos/lesõesRESUMO
Anesthesia for llamas is similar to other domestic species, although adjustments in technique are required to allow for species variations. Xylazine (0.4-0.6 mg/kg) is well tolerated for sedation. The thiobarbiturates (8-10 mg/kg), ketamine (2.5-5.0 mg/kg), or combinations of guaifenesin and thiobarbiturates or guaifenesin and ketamine (to effect) can be used for induction of anesthesia. In juvenile or debilitated animals, anesthesia can be induced with halothane or isoflurane administered by mask. After tracheal intubation, anesthesia can be maintained with the inhalation agents, usually halothane or isoflurane. Supportive therapy and many anesthetic monitoring techniques used in domestic animals can be used in llamas. While under marginal planes of anesthesia, llamas can have more active physiologic responses to pain, including bradycardia and vasoconstriction, than domestic animals. Llamas are more prone to airway obstruction after tracheal extubation than domestic ruminants but otherwise recover as well from general anesthesia as domestic ruminants.
Assuntos
Anestesia/veterinária , Artiodáctilos/fisiologia , Camelídeos Americanos/fisiologia , Período de Recuperação da Anestesia , Animais , Camelídeos Americanos/sangue , Hipnóticos e Sedativos , Intubação Intratraqueal/veterinária , Monitorização Fisiológica/veterinária , Valores de ReferênciaRESUMO
Unilateral congenital medial patellar luxation in a young llama was corrected by medial joint capsule release, tibial crest transposition, trochleoplasty, and lateral joint capsule imbrication. The techniques used were the same as described in the dog. One year after surgery, the llama was not lame, but had a valgus deformity originating at the stifle, most likely caused by lateral femoral condyle hypoplasia.
Assuntos
Artiodáctilos , Camelídeos Americanos , Membro Posterior/cirurgia , Luxações Articulares/veterinária , Joelho de Quadrúpedes/cirurgia , Animais , Parafusos Ósseos/veterinária , Fios Ortopédicos/veterinária , Luxações Articulares/congênito , Luxações Articulares/cirurgia , MasculinoRESUMO
Nasomaxillary fibrosarcoma was diagnosed in 3 young horses. Clinical signs included epiphora, facial swelling, dyspnea, unilateral serosanguineous nasal discharge, or an external mass. Physical examination, radiography, and cytology were important diagnostic adjuncts. The definitive diagnosis in each case was based on biopsy. In one case, surgical removal of the tumor and extensive curettage of the affected sinus resulted in extended remission from neoplastic disease.
Assuntos
Fibrossarcoma/veterinária , Doenças dos Cavalos/diagnóstico , Neoplasias Maxilares/veterinária , Neoplasias Nasais/veterinária , Animais , Diagnóstico Diferencial , Feminino , Fibrossarcoma/diagnóstico , Fibrossarcoma/ultraestrutura , Doenças dos Cavalos/patologia , Cavalos , Masculino , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/ultraestrutura , Microscopia Eletrônica , Neoplasias Nasais/diagnóstico , Neoplasias Nasais/ultraestrutura , Sarcoma/diagnóstico , Sarcoma/ultraestrutura , Sarcoma/veterináriaRESUMO
A juvenile granulosa cell tumour is described in a 3-month-old Arabian filly. The 32 X 27 X 27 cm tumour had replaced the right ovary. The neoplasm was composed of multiple nodules of neoplastic granulosa cells which formed microfollicles, macrofillicles and cysts, as well as solid nests and trabeculae. The supporting stroma contained theca cells. Mixing of the neoplastic granulosa cells and theca cells in disorderly fashion was noted. The diagnosis was based on age of occurrence and histological appearance.
Assuntos
Tumor de Células da Granulosa/veterinária , Doenças dos Cavalos/patologia , Neoplasias Ovarianas/veterinária , Desmame , Animais , Feminino , Tumor de Células da Granulosa/patologia , Cavalos , Neoplasias Ovarianas/patologiaAssuntos
Fibrossarcoma/veterinária , Doenças dos Cavalos/patologia , Neoplasias do Seio Maxilar/veterinária , Neoplasias dos Seios Paranasais/veterinária , Animais , Feminino , Fibrossarcoma/patologia , Fibrossarcoma/ultraestrutura , Cavalos , Masculino , Neoplasias do Seio Maxilar/patologia , Neoplasias do Seio Maxilar/ultraestrutura , Microscopia Eletrônica , Neoplasias dos Seios Paranasais/patologia , Neoplasias dos Seios Paranasais/ultraestruturaRESUMO
For each of 3 separate evaluations, 6 fasted llamas (Lama glama) were sedated with xylazine (1.1 mg/kg of body weight, IV) and then 15 minutes later were given normal saline solution (5.0 ml, IV; control values), doxapram (2.2 mg/kg, IV), or 4-amino-pyridine (0.3 mg/kg, IV) and yohimbine (0.125 mg/kg, IV). After administration of 4-aminopyridine and yohimbine, the llamas stood in a mean of 11 minutes and resumed eating in a mean of 34 minutes; both means were significantly less (P less than 0.05) than control values (46 minutes and 67 minutes, respectively). Doxapram induced muscle fasciculations, and (compared with control values) did not significantly decrease the time to standing (41 minutes) or the time until the animals resumed eating (68 minutes). Yohimbine and 4-aminopyridine in combination rapidly antagonized xylazine-induced sedation in llamas, whereas doxapram was ineffective as an antagonist of xylazine-induced sedation.