RESUMO
BACKGROUND: Betel-nut use is associated with metabolic syndrome and obesity. However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. The present study was conducted to determine the association between betel-nut chewing and CKD in men. METHODS: We retrospectively reviewed health-check records of 3264 men in a hospital-based cross-sectional screening programme from 2003 to 2006. CKD was defined as estimated glomerular filtration rate less than 60 ml/min/1.73 m2 calculated by the Modification of Diet in Renal Disease formula. Risk factors for CKD including diabetes, hypertension, BMI, smoking, alcohol consumption and age were also considered. RESULTS: A total of 677 (20.7 %) men were found to have CKD and 427 (13.1 %) participants reported a history of betel-nut use. The prevalence (24.8 %) of CKD in betel-nut users was significantly higher than that (11.3 %) of participants without betel-nut use (P = 0.026). In multivariate logistic regression analysis with adjustments for age, hypertension, diabetes and hyperlipidaemia, betel-nut use was independently associated with CKD (P < 0.001). The adjusted odds ratio for betel-nut use was 2.572 (95 % CI 1.917, 3.451). CONCLUSIONS: Betel-nut use is associated with CKD in men. The association between betel-nut use and CKD is independent of age, BMI, smoking, alcohol consumption, hypertension, diabetes and hyperlipidaemia.
Assuntos
Areca/efeitos adversos , Nefropatias/induzido quimicamente , Nefropatias/epidemiologia , Doença Crônica , Comorbidade , Estudos Transversais , Taxa de Filtração Glomerular , Hospitais , Humanos , Nefropatias/diagnóstico , Modelos Logísticos , Masculino , Mastigação , Prontuários Médicos , Prevalência , Fatores de Risco , Taiwan/epidemiologiaRESUMO
OBJECTIVE: This study was conduced to access the association between betelnut chewing and chronic kidney disease (CKD) in adults. METHODS: We retrospectively reviewed 3,552 participants (1,418 men and 2,134 women) younger than 65 in this hospital-based cross-sectional study from 2003 to 2006. RESULTS: A total of 198 (5.6%) participants were found to have CKD and 287 (8.1%) participants (268 male and 19 female) reported a history of betelnut use. The prevalence (9.4%) of CKD in betelnut users was significantly higher than that (5.2%) of participants without betelnut use (P = 0.003). In multivariate logistic regression with adjustment for age, sex, hypertension, and diabetes, betelnut use and body mass index were independently associated with CKD (P = 0.026 and P = 0.038). CONCLUSIONS: Betelnut use is associated with chronic kidney disease in adults younger than 65.