[The immunological indices of diabetic patients following the transplantation of a pancreatic islet cell culture]. / Deiaki imunolohichni pokaznyky u khvorykh na tsukrovyi diabet pislia transplantatsiï ïm kul'tury ostrivtsevykh klityn pidshlunkovoï zalozy.

Some indices of cell-mediated and humoral immunity were studied in 35 patients with insulin-dependent diabetes mellitus before and 7, 14 days, 3, 6, and 12 months after transplantation of pancreatic islet cell culture obtained from newborn pigs into m. rectus abdominis. It was established that the transplantation does not affect number of T- and B-lymphocytes, T-helpers, T-suppressors and level of antibodies to insulin. Clinical effect depended on the base level of transplantation immunity. Favourable results, such as liquidation of hypoglycaemia and reduction of exogenic insulin at the background of improved general condition may be expected in cases with high of heterophilic haemagglutinins low cytotoxicity index and increased number of sensibilized leukocytes.

[The level of glycosylated hemoglobin A1c in the erythrocytes of patients with diabetic angio- and polyneuropathies]. / Uroven' glikozilirovannogo gemoglobina A1c v éritrotsitakh bol'nykh s diabeticheskimi angio- i polineiropatiiami.

The level of glycosylated Hb A1c in erythrocytes of 173 patients with types I and II diabetes mellitus was analyzed with regard to compensation of disease, the presence and a degree of expression of diabetic angiopathies. An elevated level of Hb A1c in decompensation of diabetes decreased after achieving normoglycemia and aglycemia without reaching the normal level. The development of severe diabetic angiopathies, especially nephro- and retinopathies was accompanied by a decrease in the level of Hb A1c in decompensation up to values which could be observed during compensation of diabetes mellitus. A conclusion is that the level of Hb A1c in erythrocytes of patients with diabetes mellitus as an indicator of carbohydrate metabolic compensation can be used only in persons with unaffected vessels or at the early stages of the development of vascular affection.

[Certain metabolic and vascular changes in the relatives of patients with diabetes mellitus]. / Nekotorye metabolicheskie i sosudistye izmeneniia u rodstvennikov bol'nykh sakharnym diabetom

On the basis of instrumental and biochemical study of 186 relatives suffering from diabetes mellitus it was revealed that the diabetic type of sugar curve was encountered in 17.2% of cases, doubltful--in 15.6%; at the same time there was revealed an increase in the immunoreactive insulin level both on fasting stomach and after the glucose load, and a distrubance of fat-lipoid metabolism. Functional changes in the vessels of different calibre independent of the GTT character, accompanied by a reduction of vascular permeability and tissue circulation were revealed in some of the persons examined.