Investigation of miscibiliy and physicochemical properties of synthetic polypeptide with collagen blends and their wound healing characteristics.

A suitable condition is needed to foster a rapid recovery of wounds, which is a dynamic and intricate process. The development and characterization of mats of plastic-like peptide polymer (PLP) with collagen for wound healing applications are reported in this work. Viscosity parameters such as the Huggins coefficient [KH], the intrinsic viscosity [η], α by Sun, ∆[η]m by Garcia ∆B and µ suggested by Chee, ∆K, and ß advocated by Jiang and Han, recommend the miscibility of the polypeptide in solution phase. Fourier transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray diffraction (XRD) methods in a solid phase. Thermal characteristics using a differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA) showed higher stability for the blends than the pure polymers. The collagen and PLP blends showed exceptional in vitro cytocompatibility, and the in vivo wound-healing studies on the Sprague-Dawley rats demonstrated faster wound healing within two weeks compared to the cotton gauze-treated injuries. Therefore, these membranes can be a possible alternative for treating skin injuries.

Miscibility studies of plastic-mimetic polypeptide with hydroxypropylmethylcellulose blends and generation of non-woven fabrics.

In the current investigation, the results of viscometric measurements, thermal property, SEM, XRD and FTIR of the polymer blends containing synthetic plastic-based polypeptide (PLP) with hydroxypropylmethylcellulose (HPMC) on miscibility is discussed. Various interaction parameters; KH, Δ[η]m, ΔB, µ, α, ß and ΔK indicated the miscibility of polypeptide/HPMC up to 40% of the PLP in the blend at room temperature. The calorimetric results a single glass transition event for miscible systems. Further, the results were aligned with the scanning electron microscope and XRD analysis. Details concerning the nature of interactions in these systems and how they are influenced by the peptide proportion in the blends are discussed. The thermo gravimetric analysis manifested the improved thermal stability of the blends than their individual polymers. Additionally, the blend solutions were fabricated into non-woven fabrics with electrospinning technique, which may be a good candidate for pharmaceutical and biomedical applications.