1.
Chem Commun (Camb)
; 55(48): 6850-6853, 2019 Jun 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31123731
RESUMO
PAGE and UV melting analysis revealed that longer LNA-based splice-switching oligonucleotides (SSOs) formed secondary structures by themselves, reducing their effective concentration. To avoid such secondary structure formation, we introduced 7-deaza-2'-deoxyguanosine or 2'-deoxyinosine into the SSOs. These modified SSOs, with fewer secondary structures, showed higher exon skipping activities.