RESUMO
OBJECTIVE: To analyze the correlation between circulating homocysteine (Hcy) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and poststroke depression (PSD). MATERIALS AND METHODS: Chinese (Chinese National Knowledge Infrastructure, Wanfang, and VIP) and English (PubMed, EMBASE, MEDLINE, and Cochrane Library) databases on the correlation between circulating Hcy and Lp-PLA2 and PSD were collected. Meta-analysis was performed to compare the distinctions in circulating Hcy and Lp-PLA2 levels between PSD and non-PSD groups. Meta-analysis was conducted by using STATA 15.0 software. RESULTS: A total of 20 literatures were included in this study. The level of circulating Lp-PLA2 in the PSD group was obviously higher than that in the non-PSD group (weighted mean differences: 2.75, 95%CI: 0.10-5.39, Pâ =â .002), which was an independent predictor of PSD (effect sizeâ =â 0.05, 95%CI: 0.03, 0.07, Pâ <â .001). The level of circulating Hcy in the PSD group was obviously higher than that in the non-PSD group (weighted mean differencesâ =â 1.41, 95%CI: 1.01, 1.81, Pâ <â .001), which was an independent influencing factor for the occurrence of PSD (effect sizeâ =â 0.07, 95%CI: 0.04, 0.09, Pâ =â .011). CONCLUSION: Circulating Hcy and Lp-PLA2 levels are linked to the development of PSD, and can be applied as predictive or diagnostic indicators.