THE STUDY OF LIVER AND KIDNEY FUNCTION WITHIN COVID-19 PATIENTS.

Goal -the existing data on the coronavirus disease 2019 (COVID-19) revealed the impact of the disease on different organs such as the liver, the heart, the kidneys, etc. In our study, we evaluated the clinical characteristics of COVID-19 in patients with abnormal liver and kidney test results in recovered and dead patients. The number of the covid-19 patients was - 289. The gold standard method of polymerase chain reaction (PCR) was used to detect the infection of Covid-19. Blood plasma was used as research material. For The Determination of ALT, AST, and Creatinine, the Analyzer was the Prestige 24i - optimized, modified method according to the International Federation of Clinical Chemistry (IFCC), without pyridoxal phosphate; For the statistical analysis were used the Graphed Prism (Version 8.0). Studies have revealed an increase in AST and ALT compared with the reference value. A small difference was also found between those who died and those who recovered; A change in creatinine levels was also found. Men have a high level of Creatinine (~4.28 times) compared to the reference level, and in women, the level of Creatinine is ~2.18 times higher than the reference level. We have thought that according to our results, the high creatinine levels may have some risk impact for the severity of COVID-19 disease.

THE STUDY OF VDR FOKI RS2228570 SNP IN AUTOIMMUNE THYROIDITIS.

Autoimmune thyroid disease (AITD) is a common organ-specific autoimmune disease. A strong influence of genetic and epigenetic modifications has been demonstrated to take part in the development and progression of autoimmune thyroid diseases. The linkage between the Vitamin D receptor (VDR) polymorphism and several autoimmune disorders, including the AITD. In this article, we aim to investigate the Frequency of VDR Fokl (rs2228570) genotypes (CC, CT, TT) and alleles (C,T) in autoimmune thyroiditis. The investigation of VDR Fokl (rs2228570) was conducted on 150 samples (control (75 healthy women) and diseased women (75 diseased with autoimmune thyroiditis)) patients from the Adjara (Georgia) Population. It also examined some clinical and laboratory characteristics of the study population. Autoimmune thyroiditis's disease was diagnosed by measuring blood antibodies, determining the level of thyroperoxidase, and conducting an ultrasound examination. Anti-TPO and TSH were studied using the ELISA method. The genomic DNA was extracted from the peripheral blood. The polymerase chain reaction was evaluated to examine the VDR Fokl rs2228570 SNP polymorphism. According to VDR Fokl (rs2228570) genotypes (CC; CT, TT) frequency, in the control group, the Frequency of CC-genotype is 48%, CT-heterozygous genotype is 29.33%, and TT-genotype is 22.67%; in the diseased population, the Frequency of CC-genotype is 57.33%, CT-genotype is 34.67%, and TT-genotype is 8%. According to VDR Fokl (rs2228570) alleles (C, T), the Frequency of the C-allele is high, and the Frequency of the T-allele is low in both populations. The Frequency of the CC and CT genotypes of VDR Fokl (rs2228570) is high in the population with autoimmune thyroiditis compared to the control group; the TT genotype is relatively low in the population suffering from autoimmune thyroiditis; According to VDR Fokl (rs2228570) alleles (C, T), the Frequency of C-allele is high both population.