RESUMO
Daily exposure of mouse recipients of Ehrlich ascites carcinoma to electromagnetic radiation of the microwave range leads to a change in the dynamics of tumor growth by decreasing the total number of cells. The number of tumor cells with blebbing morphological signs after microwave radiation increases gradually with tumor growth. The maximum content of tumor cells in the state of blebbing is observed during active proliferation in tumor-recipient mice of the control group (without irradiation).
Assuntos
Carcinoma de Ehrlich/patologia , Carcinoma de Ehrlich/fisiopatologia , Proliferação de Células/efeitos da radiação , Campos Eletromagnéticos , Micro-Ondas , Animais , Apoptose/efeitos da radiação , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos da radiação , Relação Dose-Resposta à Radiação , Masculino , Camundongos , Camundongos Endogâmicos ICR , Doses de Radiação , Irradiação Corporal TotalRESUMO
It is shown that the transport of oxygen through the surface of the isolated perfused rat liver is an energy-dependent process that requires the energy of ATP hydrolysis.
Assuntos
Trifosfato de Adenosina/metabolismo , Fígado/metabolismo , Consumo de Oxigênio , Oxigênio/metabolismo , Animais , Transporte Biológico Ativo/efeitos dos fármacos , Transporte Biológico Ativo/fisiologia , Fármacos Cardiovasculares/farmacologia , Cobalto/farmacologia , Simulação por Computador , Difusão , Técnicas In Vitro , Fígado/efeitos dos fármacos , Masculino , Modelos Biológicos , Consumo de Oxigênio/efeitos dos fármacos , Ratos WistarRESUMO
The paper deals with an approach to the description of the age and temporal dynamics of cancer, based on the model describing the dynamics of the age of cancer as a second order phase transition. This approach is widely used for studying physical systems. This model of cancer development as second order phase transitions is in a good agreement with medical statistics. The cancer incidence dynamics is described only with two free parameters, easily verified according to statistics and well interpreted. The applicability of the second order phase transition model for description of a non-physical system defines the universal nature of the processes occurring during phase transitions.
Assuntos
Modelos Estatísticos , Neoplasias/diagnóstico , Neoplasias/epidemiologia , Dinâmica Populacional/estatística & dados numéricos , Adulto , Distribuição por Idade , Fatores Etários , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oriente Médio/epidemiologia , Neoplasias/classificação , Neoplasias/patologia , Federação Russa/epidemiologia , Fatores Sexuais , Estados Unidos/epidemiologiaRESUMO
One of the possible mechanisms of initiation of local phase transitions and formation of nonuniform structure of biological and model lipid membranes is suggested. It is based on anisotropic electrohydrodynamic instability of Kupershtokh and Medvedev in strong electric field relative to density perturbations. This mechanism may clarify initial stages of formation of membrane domains and pores, some aspects of cell signalization and influence of microwave irradiation of nonthermal intensity on living organisms.
Assuntos
Bicamadas Lipídicas/química , Microdomínios da Membrana/química , Eletroquímica , Campos Eletromagnéticos , Bicamadas Lipídicas/efeitos da radiação , Microdomínios da Membrana/efeitos da radiação , Potenciais da Membrana , Micro-Ondas , Transição de Fase , Eletricidade Estática , TermodinâmicaRESUMO
An experimental dosage form of rubomycin is developed: the drug is incorporated in absorbable polymeric (polyhydroxybutyrate) matrix in the form of microparticles. Antitumor efficiency of this rubomycin dosage form was studied in laboratory mice with transplanted Ehrlich ascitic carcinoma. Rubomycin deposited in polymeric microparticles exhibited pronounced antitumor activity, inhibited the proliferative activity of Ehrlich ascitic carcinoma, and improved survival of mice with tumors. This dosage form of the drug can be used for local injections.
Assuntos
Antibióticos Antineoplásicos/administração & dosagem , Antibióticos Antineoplásicos/uso terapêutico , Daunorrubicina/administração & dosagem , Daunorrubicina/uso terapêutico , Microesferas , Absorção , Animais , Carcinoma de Ehrlich/tratamento farmacológico , Carcinoma de Ehrlich/mortalidade , Hidroxibutiratos , Camundongos , Camundongos Endogâmicos BALB C , PoliésteresRESUMO
A new approach based on local interaction between cancer and tissue cells was applied to the problem of the onset and growth of solid tumors in homogeneous tissues and effects associated with dramatic changes in tumor growth after crossing the boundary between different tissues. The characteristic sizes and growth rates of spherical tumors, the points of the beginning and the end of spherical growth, and the further development of complex structures from the spherical ones (rough interface between the tumor and the host tissue, elongate outgrowths, dendritic structures, and metastases) were inferred assuming that the reproduction rate of a population of cancer cells is a nonmonotone function of their local concentration and thus of the local curvature of the tumor surface.
Assuntos
Modelos Biológicos , Neoplasias/fisiopatologia , Animais , Progressão da Doença , Humanos , Neoplasias/metabolismoRESUMO
A model consisting of two blocks (equations) was proposed for the analytical study of the biosphere-climate system over great periods of time. The first equation describes the balance of carbon dioxide in the atmosphere and represents the biological block of the model. The second equation is the equation of the energy balance or the physical block of the system. The model is based on the most general conceptions of living matter and the evolution process. A possible interpretation of some events and phenomena in the earth history in terms of the model is given.
Assuntos
Evolução Biológica , Clima , Modelos Teóricos , Ecologia/métodosAssuntos
Comportamento Competitivo/fisiologia , Ecossistema , Modelos Biológicos , Dinâmica Populacional , Animais , Simulação por Computador , Insetos/crescimento & desenvolvimento , Insetos/fisiologia , Plâncton/fisiologia , Crescimento Demográfico , Controle de Qualidade , Especificidade da EspécieRESUMO
This paper shows it possible to use geoinformational systems for mapping and analyzing medical statistical data on those with malignant laryngeal neoplasms. The fact that the distribution of the patients can be shown on the map of a town in relation to the location of their houses (if they have an address) allows differentiation of the ecological living conditions of these patients, which in turn makes it possible to put not only high morbidity areas on the map of a town, but also to consider the characteristics of the environment in these areas.