RESUMO
It is becoming progressively more understandable that different phytochemicals isolated from edible plants interfere with specific stages of carcinogenesis. Cancer cells have evolved hallmark mechanisms to escape from death. Concordant with this approach, there is a disruption of spatiotemproal behaviour of signaling cascades in cancer cells, which can escape from apoptosis because of downregulation of tumor suppressor genes and over- expression of oncogenes. Genomic instability, intra-tumor heterogeneity, cellular plasticity and metastasizing potential of cancer cells all are related to molecular alterations. Data obtained through in vitro studies has convincingly revealed that curcumin, EGCG, resveratrol and quercetin are promising anticancer agents. Their efficacy has been tested in tumor xenografted mice and considerable experimental findings have stimulated researchers to further improve the bioavailability of these nutraceuticals. We partition this review into different sections with emphasis on how bioavailability of curcumin, EGCG, resveratrol and quercetin has improved using different nanotechnology approaches.
Assuntos
Catequina/análogos & derivados , Curcumina/farmacologia , Neoplasias/tratamento farmacológico , Quercetina/farmacologia , Estilbenos/farmacologia , Animais , Anticarcinógenos/farmacologia , Antineoplásicos/farmacologia , Antioxidantes/farmacologia , Apoptose/efeitos dos fármacos , Catequina/farmacologia , Proliferação de Células/efeitos dos fármacos , Transformação Celular Neoplásica , Portadores de Fármacos/farmacologia , Humanos , Ácido Láctico/química , Ácido Láctico/farmacologia , Camundongos , Nanopartículas , Compostos Fitoquímicos/farmacologia , Ácido Poliglicólico/química , Ácido Poliglicólico/farmacologia , Poli-Hidroxietil Metacrilato/química , Poli-Hidroxietil Metacrilato/farmacologia , Copolímero de Ácido Poliláctico e Ácido Poliglicólico , Resveratrol , Dióxido de Silício , Ensaios Antitumorais Modelo de XenoenxertoRESUMO
Increasingly it is being realized that despite considerable advancements in therapeutic interventions related to treatment of cancer, satisfactory results are still difficult to achieve. Rapidly accumulating evidence has started to shed light on the fact that cancer cells escape from death via constitutive activation of pro-survival signaling cascades. Cell biology and genetics have extensively enhanced our current understanding of the molecular mechanisms that underlie loss of apoptosis in cancer cells. This review is focused on ionizing radiation mediated restoration of TRAIL mediated apoptosis as evidenced by cell culture and animal model studies. Moreover, we also bring to the limelight radiation induced expression of miRNAs and how miRNAs further control response of cancer cells to radiation.