Transarterial chemoembolisation for palliative treatment of renal cell carcinoma in two dogs with pulmonary metastasis.

Two dogs with anorexia and rapid weight loss were referred to our hospital due to a right renal mass and several pulmonary nodules. Both dogs underwent needle core biopsy of the mass, followed by transarterial chemoembolisation of the renal mass. A catheter was inserted from the femoral artery and advanced into the right renal artery. A suspension of carboplatin (100 mg/m2 ) and equivalent lipiodol was administered via the inserted multipurpose catheter. Immediately after, under fluoroscopic guidance, pulse injections of small amounts of gelatin particles (diameter 1 mm) dissolved in iohexol were administered until complete embolisation of the renal artery. Histopathologic diagnosis was renal cell carcinoma in both dogs. Clinical signs improved for 134 and 358 days after transarterial chemoembolisation. In addition, postoperative radiographs demonstrated a decrease in the tumour size. The dogs died 215 and 525 days after the initial evaluation, respectively. As a palliative treatment, transarterial chemoembolisation might help reduce the tumour volume and improve the quality of life in dogs with renal cell carcinoma and distant metastases.

A serological comparison of 4 Japanese isolates of porcine enteroviruses with the international reference strains.

The reference strains of four serotypes (J6, J8, J9 and J10) of porcine enterovirus isolated in Japan were compared with the international reference strains of 11 serotypes (W1 to W11) by cross neutralization tests. No cross reactions were observed between the two groups, although there were minor one-way crosses between W10 and J10, W11 and J9, and W4 and J9. This leads to our conclusion that all 4 Japanese serotypes can be newly added to 11 international serotypes. J9 virus produced type 1 of CPE (CPE I), J6 and J8 did CPE II, and J10 did CPE III. J10 grew in Vero, HeLa cells, and the primate cells, but J6, J8 and J9 did not.

Sero- and CPE-types of porcine enteroviruses isolated from healthy and diarrheal pigs: possible association of CPE type II with diarrhea.

Porcine enteroviruses (PEV) were isolated from feces of healthy and diarrheal domestic Japanese pigs, and examined for their serotypes. Each virus of the isolates corresponded not only to the Japanese version of the reference serotype, but also to its corresponding world version of the reference serotype. Twenty-two samples (75.9%) of 29 isolates from the feces of healthy pigs exhibited a characteristic of CPE I. On the other hand, 69.2% (27/39) of all diarrheal pigs showed a characteristic of CPE II. This would suggest the PEV with CPE II has a closer association with the enteric pathogenicity than that with CPE I.