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1.
Healthcare (Basel) ; 11(18)2023 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-37761749

RESUMO

This paper contributes to the ongoing discussion in the United Kingdom regarding euthanasia and assisted dying, using data specifically related to individuals with dementia. A qualitative approach was taken with data captured via a set of written questions in the form of a Mass Observation Archive Directive. The respondents, known as Observers, provided written responses; there was no limit to the length of the responses and the Observers were able to provide as much or as little detail as they chose. The data were analysed thematically utilising NVivo software. One-hundred and seven responses were received, representing a range of beliefs, and with opinions regarding euthanasia and dementia with pro, anti, and uncertain views being expressed. Five main themes emerged during our data analysis: capacity, legislation, agency and personal philosophies, disquietude, and incumbrance. Consistent with previous research capturing public views regarding euthanasia and assisted dying for people with dementia, the findings suggest policy makers may wish to consult the British public regarding legislation regarding euthanasia and dementia.

2.
BJGP Open ; 7(4)2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37491083

RESUMO

BACKGROUND: Mental ill-health in older adults (aged 60 years and over) is often underdiagnosed and undertreated. Older adults are less likely to access mental health services owing to perceived stigma and fear of being a burden. Non-traditional providers of health care, such as the Fire and Rescue Services (FRS), provide a possible solution to facilitate early detection of problems and help-seeking among older adults, especially in the context of pressured statutory services. AIM: To examine whether and how FRS Home Fire Safety Visits (HFSV) could be optimised to include detection and signposting for mental health problems - particularly anxiety and depression - in older adults. DESIGN & SETTING: This mixed-method qualitative study took place in the West Midlands, UK in 2022. METHOD: This study involved focus groups (n = 24) and interviews with FRS staff (n = 4) to develop an in-depth contextual understanding of he acceptability and feasibility of expanding HFSV to include identification of anxiety and depression. RESULTS: FRS staff were open to expanding their HFSVs to include mental health, provided they had sufficient training and support from partner agencies in primary and social care settings to accept referrals for service users presenting with symptoms of anxiety and/or depression. CONCLUSION: The positive reputation of FRS staff and engagement with older adults suggests that HFSV could support the detection of anxiety and depression in older adults, and appropriate signposting to other services including primary care.

3.
Bull World Health Organ ; 100(4): 268-275, 2022 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-35386551

RESUMO

Preventing noncommunicable diseases is a global priority, for which the World Health Organization has recommended policies to reduce the consumption of tobacco products, alcohol and unhealthy foods. However, regulation has been strongly opposed by affected industries, who have invoked the provisions of legally binding trade and investment agreements. The aim of this analysis of the legal, economic and public health literature was to present a short primer on the relationship between noncommunicable disease prevention policy and trade and investment agreements to help public health policy-makers safeguard public health policies. The analysis identified opportunities for protecting, and even promoting, public health in trade and investment agreements, including: (i) ensuring exceptions for public health measures are included in agreements; (ii) committing to good regulatory practice that balances transparency and cooperation with the need for governments to limit the influence of vested interests; (iii) ensuring trade and investment agreement preambles acknowledge the importance of public health; (iv) excluding investor-state dispute settlement mechanisms from agreements; and (v) limiting the scope and definition of key provisions on investor protection to reduce the risk of investment disputes. This synthesis of the multidisciplinary literature also provides support for greater strategic and informed engagement between the health and trade policy sectors. In addition, ensuring a high level of health protection in trade and investment agreements requires cooperation between disciplines, engagement with experts in law, economics and public health policy, and fully transparent policy processes and governance structures.


La prévention des maladies non transmissibles constitue une priorité mondiale. Dans ce contexte, l'Organisation mondiale de la Santé a recommandé des politiques visant à réduire la consommation de produits du tabac, d'alcool et d'aliments nocifs pour la santé. Néanmoins, cette régulation s'est heurtée à une forte opposition de la part des industries concernées, qui ont invoqué les dispositions prévues dans les accords juridiquement contraignants en matière de commerce et d'investissement. La présente analyse se penche sur la littérature juridique, économique et de santé publique. Son but: décrire brièvement la relation entre les mesures de prévention des maladies non transmissibles d'une part, et les accords en matière de commerce et d'investissement d'autre part, afin d'aider les législateurs compétents à défendre les politiques de santé publique. Cette analyse a identifié divers moyens de préserver, voire de promouvoir la santé publique dans les accords de commerce et d'investissement, notamment: (i) en veillant à inclure des exceptions pour les mesures de santé publique dans les accords; (ii) en s'engageant à respecter les bonnes pratiques réglementaires, qui concilient la transparence et la coopération avec la nécessité, pour les gouvernements, de limiter l'influence des intérêts en place; (iii) en s'assurant que les accords de commerce et d'investissement mentionnent dans leur préambule l'importance de la santé publique; (iv) en excluant de ces accords les mécanismes de règlement des différends entre États et investisseurs; et enfin, (v) en limitant la portée et la définition des dispositions fondamentales sur la protection des investisseurs afin de diminuer le risque de différend. Cette synthèse de littérature multidisciplinaire contribue également à plus d'engagement stratégique et éclairé entre les politiques sanitaires et commerciales. En outre, garantir un haut niveau de protection sanitaire dans les accords de commerce et d'investissement implique une collaboration entre plusieurs disciplines, la mobilisation d'experts en droit, en économie et en politiques de santé publique, ainsi que des structures de gouvernance et des processus d'élaboration des politiques entièrement transparents.


La prevención de las enfermedades no transmisibles es una prioridad mundial, por lo que la Organización Mundial de la Salud ha recomendado la adopción de políticas para reducir el consumo de productos de tabaco, alcohol y alimentos malsanos. Sin embargo, las industrias afectadas se han opuesto con firmeza a la regulación, invocando las disposiciones de los acuerdos comerciales y de inversión jurídicamente vinculantes. El objetivo de este análisis sobre la documentación jurídica, económica y de salud pública fue presentar una breve introducción sobre la relación entre la política de prevención de las enfermedades no transmisibles y los acuerdos comerciales y de inversión para ayudar a las autoridades responsables de formular las políticas de salud pública a protegerlas. El análisis identificó oportunidades para proteger, e incluso promover, la salud pública en los acuerdos comerciales y de inversión, que incluyen i) garantizar la inclusión de excepciones para las medidas de salud pública en los acuerdos; ii) comprometerse con las buenas prácticas regulatorias que equilibran la transparencia y la cooperación con la necesidad de los gobiernos de limitar la influencia de los intereses creados; iii) garantizar que los preámbulos de los acuerdos comerciales y de inversión reconocen la importancia de la salud pública; iv) excluir de los acuerdos los mecanismos de resolución de disputas entre inversores y Estados; y v) limitar el alcance y la definición de las disposiciones clave sobre la protección de los inversores para reducir el riesgo de disputas sobre las inversiones. Esta síntesis de la documentación multidisciplinar también respalda un mayor compromiso estratégico e informado entre los sectores de la salud y la política comercial. Además, se requiere la cooperación entre las disciplinas, la participación de especialistas en derecho, economía y política de salud pública, y procesos políticos y estructuras de gobernanza totalmente transparentes para garantizar un alto nivel de protección de la salud en los acuerdos comerciales y de inversión.


Assuntos
Doenças não Transmissíveis , Comércio , Política de Saúde , Humanos , Investimentos em Saúde , Doenças não Transmissíveis/prevenção & controle , Saúde Pública , Política Pública
4.
J Elder Abuse Negl ; 34(1): 70-76, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34913852

RESUMO

During the COVID-19 pandemic the risks to older adults of systemic abuse and neglect have become amplified, alongside increasing abuse and neglect in the community. Novel risks have also evolved involving cybercrime and the use of remote technologies in health and social care related to the pandemic. This commentary brings together lessons to be learned from these developments and initial ideas for actions to mitigate future risks.


Assuntos
COVID-19 , Abuso de Idosos , Idoso , Humanos , Pandemias , Fatores de Risco , SARS-CoV-2
5.
Healthcare (Basel) ; 9(8)2021 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-34442138

RESUMO

The research aim was to evaluate the rationale of undergraduate final-year student nurses to undertake paid clinical placements during COVID-19 (Wave 1). The nursing profession reacted innovatively to meet demands placed on the National Health Service during COVID-19. Temporary changes to professional regulation enabled final-year United Kingdom nursing students to voluntarily undertake paid placements in the National Health Service. Neither full-time employees nor full-time students, volunteers undertook a unique hybrid role bolstering the front-line health workforce. Using reflective qualitative inquiry, 17 volunteers evaluated reasoning for entering practice in acute hospitals. Online surveys based around the UK Nursing and Midwifery Council Competency Framework (NMC 2012) were completed weekly for 6 weeks. Data were thematically analysed. Six themes were identified, including sense of duty, and opting-in or out. These highlighted the importance of collaboration and the tripartite relationship between University, host and student during placement, and the influence of these on the learning experience. Several significant insights emerged for nurse education and curricula during pandemics related to patient safety, safety climate and governance. The insights were used to develop a "Student Nurses Placement Framework" with recommendations for Pre-During-Post placement, offering a guide for future nursing workforce recruitment and retention.

6.
J Adv Nurs ; 77(1): 23-46, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33022791

RESUMO

AIM: To identify, evaluate and summarize evidence from qualitative, quantitative and mixed method studies conducted using age suits or other age simulation equipment, with health and social care students. DESIGN: Convergent segregated mixed method review design as outlined by the Johanna Briggs Institute. DATA SOURCES: CINAHL (+ with Full Text), MEDLINE, PsycINFO, PubMed, SocINDEX, Web of Science, Cochrane Library, Emerald Insight, Proquest nursing, Science Direct, Wiley Online and BioMed Central (January 2000-January 2020). REVIEW METHODS: Convergent segregated synthesis was used to synthesize evidence from the studies and the MERSQI checklist used to appraise quality. RESULTS: A total of 23 studies were reviewed: one randomized control, two post-test only randomized control, three quasi-experimental, 15 one-group pre/post studies and two qualitative studies. Of the seventeen studies carrying out inferential statistics on attitude scores post intervention, 11 reported an improvement, three indicated no significant change and three reported worsening scores. Key themes included use of appropriate scales, type of equipment used, location and length of interactions, debriefing and contextualization of interventions in broader teaching. CONCLUSION: The impact of ageing simulation interventions on health and social care student's attitudes to older people was predominantly positive. However, further high-quality research is warranted to understand the optimal use of such interventions in the context of health care for a growing ageing population. IMPACT: It is important health and social care staff have appropriate knowledge and training to enable them to provide high-quality care to older people and challenge potential ageism in the system. This review adds to the body of work around the use of simulation and experiential learning to educate health and social care students about ageing and ageism. It also offers recommendations for using ageing simulations effectively to inform attitudes of prospective professionals who will influence future health and social care.


Assuntos
Envelhecimento , Atenção à Saúde , Idoso , Humanos , Estudos Prospectivos , Pesquisa Qualitativa , Apoio Social
7.
Dementia (London) ; 19(8): 2804-2820, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31291784

RESUMO

Over 850,000 people living in the United Kingdom have been diagnosed with dementia, yet knowledge about this condition amongst the general population remains relatively poor. Many studies have evaluated the level of public knowledge and understanding about dementia from a research and professional service perspective; however, none have considered this condition from the perspective of the wider public. In this preliminary overview, we analyse and describe high-level narratives collected from 143 respondents to a Dementia Directive commissioned to the Mass Observation Project. These narratives present a perspective on the public knowledge and understanding about dementia not previously considered, where respondents have written openly about their own experiences, and reflected on their perception of the wider public's knowledge and understanding about dementia. This unique perspective importantly enhances our knowledge about the public's understanding and awareness of dementia, and informs the main areas of public concern found in the analysis: care responsibilities, impact on relationships, and fears about developing dementia.


Assuntos
Demência , Opinião Pública , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Narração , Reino Unido
9.
Exp Cell Res ; 367(1): 24-29, 2018 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-29453974

RESUMO

Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-ß3), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model. Twenty-four rabbits with surgically-induced full-thickness cutaneous wounds created on the external ear (1.5 × 1.5 cm, two wounds/ear) were randomized into four groups: (G1), wounds with no special treatment but common serum-free culture medium as negative controls; (G2), topically-applied recombinant adenovirus, expressing TGF-ß3/GFP; (G3), topically-applied BMSCs alone; (G4), topically-applied BMSCs transfected with Ad-TGF-ß3/GFP (BMSCsTGF-ß3); and (G5), an additional normal control (n = 2) with neither wound nor treatment on the external ear skin. The sizes of wounds on the ear tissues were grossly examined, and the scar depth and density of wounds were histologically evaluated 21, 45, and 90 days after surgical wound creation. Our results demonstrated that G4 significantly reduced the wound scar depth and density, compared to G1~3. Numbers of cells expressing GFP significantly increased in G4, compared to G2. The protein expression of TGF-ß3 and type III collagen in G4 significantly increased, while the ratio of type I to type III collagen was also significantly reduced, which is similar to the tissue architecture found in G5, as compared the other treatment groups. In conclusion, transplantation of BMSCsTGF-ß3 remarkably improves wound healing and reduces skin scar tissue formation in an animal model, which may potentially provide an alternative in the treatment of extensive scar tissue formation after soft tissue injury.


Assuntos
Cicatriz/terapia , Terapia Genética , Células-Tronco Mesenquimais/metabolismo , Fator de Crescimento Transformador beta3/genética , Cicatrização , Adenoviridae/genética , Animais , Colágeno Tipo I/metabolismo , Colágeno Tipo III/metabolismo , Modelos Animais de Doenças , Células-Tronco Mesenquimais/virologia , Plasmídeos/genética , Coelhos
10.
Mar Environ Res ; 129: 219-228, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28622847

RESUMO

Despite its long history of hydrocarbon exploitation, the United Kingdom lacks scientific protocols to monitor ecological impacts of drill cuttings (mixtures between rocky material excavated from wells and drilling mud). The present study used the UK Benthos industry database to apply standardised variance partitioning and measure the scale and persistence of these effects at 19 sites across the UK sector of the North Sea. Generally, effects were limited to within 1 km from the platform, but two platforms historically drilled with oil-based mud were impacted up to 1.2 km away. Impacts persisted for at least 6-8 years in the northern and central North Sea, but were undetectable in the south where cuttings piles do not accumulate. This study underpins new recommendations to implement regional, phase-based approaches to drill cuttings monitoring, and to apply a precautionary approach in considering decommissioning options that will minimise disturbance to cuttings piles.


Assuntos
Monitoramento Ambiental , Mineração , Poluentes Químicos da Água/análise , Poluição Química da Água/estatística & dados numéricos , Hidrocarbonetos , Indústrias , Mar do Norte , Petróleo , Reino Unido
11.
Dementia (London) ; 16(8): 985-1003, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26787748

RESUMO

This research aimed to ascertain the impact of a pragmatic Cognitive Stimulation Therapy course of 10 sessions on the cognitive function of people living with dementia and whether attending a concomitant carers support group was beneficial to carers. A mixed method quasi-experimental approach was adopted; data were collected pre- and post-intervention. The quantitative arm utilised three validated questionnaires rated by the carers. Qualitative data were collected via semi-structured interviews with carers regarding their perceptions of the impact of Cognitive Stimulation Therapy and the carers support group. Quantitative data analysis found no statistically significant differences within or between groups. The qualitative data demonstrated that carers perceived Cognitive Stimulation Therapy had some benefits for the people living with dementia, especially social benefits. Carers also perceived that attending the carers support group was beneficial for them in terms of gaining a better understanding of dementia, developing coping skills and having peer support. The study was limited in scale and further research with a larger sample, using direct measures of the impact of Cognitive Stimulation Therapy with people living with dementia and supplementary research exploring which characteristic of carers support groups are effective would be worthwhile.


Assuntos
Cuidadores/psicologia , Terapia Cognitivo-Comportamental/métodos , Demência/terapia , Grupos de Autoajuda , Adaptação Psicológica , Cognição , Demência/psicologia , Feminino , Humanos , Masculino , Qualidade de Vida/psicologia , Inquéritos e Questionários
12.
Sociol Health Illn ; 39(2): 212-226, 2017 02.
Artigo em Inglês | MEDLINE | ID: mdl-27891627

RESUMO

The concept of personhood developed by Tom Kitwood highlights that the experience of dementia has relational dimensions that transcend the neurodegenerative impacts of the condition. This relational focus, however, has been narrowly conceptualised, with the impact of broader sociocultural factors on experience underplayed. The empirical exploration of interaction also requires reinforcement: a tendency for dyadic studies to portray findings in an individualised format hinders the interrogation of interpersonal negotiations. This article draws upon qualitative research that employed a joint interview approach, interviewing men with dementia and their spousal carers together. The focus on a dyadic case study from this research enables methodical exploration of the experience of living with dementia. This is realised by considering the socially-framed perspective of each person, and then how their perspectives are interwoven within interactional exchanges. This provides a platform for the evaluation of the current decontextualised notion of personhood and its implications. It is concluded that a sociologically-informed perspective can help to reinforce the academic understanding of personhood.


Assuntos
Demência/psicologia , Narração , Pessoalidade , Cuidadores/psicologia , Feminino , Humanos , Entrevistas como Assunto , Masculino , Casamento , Pessoa de Meia-Idade , Pesquisa Qualitativa
13.
Iran J Basic Med Sci ; 19(3): 265-71, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27114796

RESUMO

OBJECTIVES: Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-ß (TGF-ß). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGFß1 modulator. In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromodulin on TGF-ß1 expression on diabetic nephropathy were assessed. MATERIALS AND METHODS: Forty-eight Sprague-Dawley rats were divided into 4 groups: STZ-induced diabetic rats (diabetic-control), fibromodulin adenovirus vector treated STZ rats (Ad- fibromodulin), and Ad-lacZ-treated STZ rats (Ad-lacZ), and vehicle control (PBS-control). At 10 weeks after STZ treatment, we measured urinary albumin excretion (UAE), urine creatinine was measured by Jaffe method. We also measured kidney TGF-ß1 levels by reverse transcription polymerase chain reaction and Real-time PCR. RESULTS: Urine albumin to creatinine ratio or UAE level were listed in four groups. UAE difference between healthy and diabetic rats in all three groups were significant (P≤0.005) and between the control group and treated groups were not significant. Our results indicated that TGF-ß1gene expression in diabetic rats were increased and difference between normal group and diabetic group were significant (P≤0.001). Fibromodulin gene transfection mediated by a recombinant adenovirus decreased TGF-ß1 level in STZ-induced diabetic rats and TGF-ß1 mRNA in diabetic kidney were reduced 2 weeks after Ad-fibromodulin injection. CONCLUSION: Intraperitoneal injection of adenoviral vectors expressing fibromodulin reduced TGF-ß1 level in diabetic rat models. The molecular mechanisms involved in this process require further study.

14.
Dementia (London) ; 15(5): 1034-52, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25249009

RESUMO

BACKGROUND: This research investigated narrative production and use with families living with dementia. We hypothesised that the process of narrative production would be beneficial to people with dementia and carers, and would elicit important learning for health and social care professionals. METHOD: Through third sector partners, we recruited community-dwelling people with dementia and carers who consented to develop written, audiotaped or videotaped narratives. Audio-taped narratives were transcribed verbatim and handwritten narratives word-processed. After checking by participants, completed narratives were analysed thematically using qualitative data analysis computer software. A summary of the analysis was circulated to participants, inviting feedback: the analysis was then reviewed. A feedback questionnaire was subsequently circulated to participants, and responses were analysed thematically. RESULTS: Twenty-one carers and 20 people with dementia participated in the project. Four themes of support were identified: 'relationships', 'services', 'prior experience of coping' and having an 'explanation for the dementia'. Three themes were identified as possible additional stresses: 'emotions', 'physical health' and 'identity'. We suggest a model incorporating all these themes, which appeared to contribute to three further themes; 'experience of dementia', 'approaches to coping' and 'looking to the future'. In participant feedback, the main themes identified were 'emotions', 'putting things in perspective', 'sharing or not sharing the narrative' and 'actions resulting'. CONCLUSIONS: Producing a narrative is a valuable and engaging experience for people with dementia and carers, and is likely to contribute to the quality of dementia care. Further research is needed to establish how narrative production could be incorporated into routine practice.


Assuntos
Cuidadores/psicologia , Demência/psicologia , Demência/terapia , Narração , Idoso , Idoso de 80 Anos ou mais , Relações Familiares/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
15.
J Med Internet Res ; 17(10): e241, 2015 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-26519106

RESUMO

BACKGROUND: The doubling of the number of people with dementia in the coming decades coupled with the rapid decline in the working population in our graying society is expected to result in a large decrease in the number of professionals available to provide care to people with dementia. As a result, care will be supplied increasingly by untrained informal caregivers and volunteers. To promote effective care and avoid overburdening of untrained and trained caregivers, they must become properly skilled. To this end, the European Skills Training and Reskilling (STAR) project, which comprised experts from the domains of education, technology, and dementia care from 6 countries (the Netherlands, Sweden, Italy, Malta, Romania, and the United Kingdom), worked together to create and evaluate a multilingual e-learning tool. The STAR training portal provides dementia care training both for informal and formal caregivers. OBJECTIVE: The objective of the current study was to evaluate the user friendliness, usefulness, and impact of STAR with informal caregivers, volunteers, and professional caregivers. METHODS: For 2 to 4 months, the experimental group had access to the STAR training portal, a Web-based portal consisting of 8 modules, 2 of which had a basic level and 6 additional modules at intermediate and advanced levels. The experimental group also had access to online peer and expert communities for support and information exchange. The control group received free access to STAR after the research had ended. The STAR training portal was evaluated in a randomized controlled trial among informal caregivers and volunteers in addition to professional caregivers (N=142) in the Netherlands and the United Kingdom. Assessments were performed with self-assessed, online, standardized questionnaires at baseline and after 2 to 4 months. Primary outcome measures were user friendliness, usefulness, and impact of STAR on knowledge, attitudes, and approaches of caregivers regarding dementia. Secondary outcome measures were empathy, quality of life, burden, and caregivers' sense of competence. RESULTS: STAR was rated positively by all user groups on both usefulness and user friendliness. Significant effects were found on a person-centered care approach and on the total score on positive attitudes to dementia; both the experimental and the control group increased in score. Regarding empathy, significant improvements were found in the STAR training group on distress, empathic concern, and taking the perspective of the person with dementia. In the experimental group, however, there was a significant reduction in self-reported sense of competence. CONCLUSIONS: The STAR training portal is a useful and user-friendly e-learning method, which has demonstrated its ability to provide significant positive effects on caregiver attitudes and empathy.


Assuntos
Demência/reabilitação , Internet/estatística & dados numéricos , Telemedicina/métodos , Cuidadores , Empatia , Feminino , Humanos , Países Baixos , Qualidade de Vida , Inquéritos e Questionários , Reino Unido
16.
Dementia (London) ; 13(2): 193-206, 2014 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-24599813

RESUMO

This paper evaluates how emergent age-based factors may impact upon the experience of dementia. A review of selected literature is undertaken to explore how personhood has been conceptualised in relation to dementia. It is then highlighted that very little literature explicitly addresses personhood with reference to young onset dementia. Young onset dementia is defined, and evaluation is then undertaken of the distinctive age-based factors that might shape the experience of the condition. It is noted that whilst there are separate literatures on both personhood and young onset dementia, there appears to be little endeavour to draw these two strands of thought together. The distinctive factors that shape young onset dementia suggest that a more heterogeneous perspective should be developed that accounts more appropriately for how personal characteristics shape the lived experience of dementia. The paper concludes that further research should be undertaken that has an explicit focus on personhood and young onset dementia.


Assuntos
Demência/epidemiologia , Demência/psicologia , Pessoalidade , Fatores Etários , Idade de Início , Humanos
17.
Hum Gene Ther ; 25(5): 443-51, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24483849

RESUMO

Transforming growth factor-ß1 (TGF-ß1) has been shown unequivocally to enhance neointima formation in carotid and ileo-femoral arteries. In our previous studies, however, TGF-ß1 expression in coronary arteries actually reduced neointima formation without affecting luminal loss postangioplasty, while expression of a TGF-ß1 antagonist (RIIs) in balloon-injured coronary arteries reduced luminal loss without affecting neointima formation. These observed effects may be a consequence of the mode of coronary artery gene transfer employed, but they may also represent differences in the modes of healing of coronary, carotid, and ileo-femoral arteries after endoluminal injury. To help clarify whether a gene therapy strategy to antagonize TGF-ß might have application within the coronary vasculature, we have investigated the effect of high-level periluminal expression of RIIs using stent-based adenovirus-mediated intracoronary gene transfer. Porcine coronary arteries were randomized to receive a custom-made CoverStent preloaded with saline only, or with 1×10(9) infectious units of adenovirus expressing RIIs or ß-galactosidase (lacZ). Vessels were analyzed 28 days poststenting, at which time angiographic in-stent diameter was significantly greater in RIIs-treated arteries, and in-stent luminal loss significantly reduced. Computerized morphometric minimum in-stent lumen area was ~300% greater in RIIs-exposed vessels than in lacZ or saline-only groups. This was because of significantly reduced neointima formation in the RIIs group. RIIs had no demonstrable effect on cellular proliferation or apoptosis, but greater normalized neointimal/medial collagen content was observed in RIIs-exposed arteries. These data highlight the qualitatively similar effect of TGF-ß antagonism on neointima formation in injured coronary and noncoronary arteries, and suggest that since cellular proliferation is unaffected, TGF-ß1 antagonism might prevent in-stent restenosis without the delayed healing that is associated with drug-eluting stents in current clinical use.


Assuntos
Adenoviridae/metabolismo , Vasos Coronários/metabolismo , Vasos Coronários/patologia , Técnicas de Transferência de Genes , Neointima/patologia , Proteínas Serina-Treonina Quinases/metabolismo , Stents , Animais , Colágeno/metabolismo , Angiografia Coronária , Vasos Coronários/diagnóstico por imagem , Vasos Coronários/efeitos dos fármacos , Expressão Gênica/efeitos dos fármacos , Células HEK293 , Humanos , Vison , Receptor do Fator de Crescimento Transformador beta Tipo II , Receptores de Fatores de Crescimento Transformadores beta , Sus scrofa , Fator de Crescimento Transformador beta1/farmacologia , Transgenes
18.
Dementia (London) ; 12(1): 29-44, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24336661

RESUMO

One of the biggest challenges facing health and social care in the United Kingdom is the projected increase in the number of older people who require dementia care. The National Dementia Strategy (Department of Health, 2009) emphasizes the critical need for a skilled workforce in all aspects of dementia care. In the West Midlands, the Strategic Health Authority commissioned a project to develop a set of generic core competencies that would guide a competency based curriculum to meet the demands for improved dementia training and education. A systematic literature search was conducted to identify relevant frameworks to assist with this work. The core competency framework produced and the methods used for the development of the framework are presented and discussed.


Assuntos
Competência Clínica/normas , Educação Baseada em Competências/organização & administração , Demência/terapia , Conhecimentos, Atitudes e Prática em Saúde , Ocupações em Saúde/educação , Mão de Obra em Saúde/normas , Desenvolvimento de Pessoal/organização & administração , Currículo , Humanos , Desenvolvimento de Programas , Reino Unido
19.
Dementia (London) ; 12(2): 268-79, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24336773

RESUMO

Dementia is a common illness that is increasing in frequency and set to challenge the resources and expertise of health and social care services over the coming years. Increasingly, there has been interest in the management of behavioural and psychological symptoms of dementia (BPSD), as they are both common and associated with a range of negative outcomes. BPSD are associated with the admission of people with dementia to care homes. Limited resources and lack of knowledge in permanent care settings often lead to BPSD being managed with antipsychotic medications, which are associated with significant morbidity and mortality. There is evidence for the benefits of exercise within care home settings, although only a few studies include those with cognitive impairment. Tai Chi is a mind-body exercise combining relaxed physical movement and meditation, and has been suggested to have many health benefits. This article discusses the rationale and available options for treating BPSD and the current practice and reviews the literature regarding the benefits of exercise and, in particular, Tai Chi in the management of BPSD.


Assuntos
Demência/reabilitação , Instituição de Longa Permanência para Idosos , Casas de Saúde , Qigong , Tai Chi Chuan , Idoso , Humanos
20.
J Ment Health ; 22(5): 402-11, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24020849

RESUMO

BACKGROUND: Following the introduction of the No Secrets (Department of Helath, (2000). No Secrets: Guidance on Developing and Implementing Multi-agency Policies and Procedures to Protect Vulnerable Adults from Abuse. London: HMSO) guidance, the implementation and development of adult safeguarding practices and procedures across national services has become an ongoing endeavour. Despite existing research highlighting practice improvements in many services, NHS mental health services are persistently criticised for their lack of engagement with the national adult safeguarding agenda ( Department of Health (2009) . Safeguarding Adults: Report on the Consultation on the Review of 'No Secrets'. London: HMSO). AIM: To investigate the organisational structure, implementation and development of adult safeguarding in NHS mental health services. METHOD: A cross-sectional survey was distributed on-line to 79 (72 NHS Mental Health Trusts in England and seven Health Boards in Wales) NHS mental health services. Results Thirty-three completed surveys were returned, yielding a response rate of 41%. The results highlight adequate arrangements for adult safeguarding in many services; however, it appears implementation is in its initial stages. Responses suggest that staff attitudes and uptake of training are the greatest barrier to practice; however, barriers are also indicated at a strategic and operational level. CONCLUSION: The importance of adult safeguarding must be recognised at all levels and there is an immediate need for improvement to staff training and engagement to ensure future effective practice in this area.


Assuntos
Serviços de Saúde Mental/organização & administração , Programas Nacionais de Saúde , Adulto , Estudos Transversais , Inglaterra , Humanos , Populações Vulneráveis , País de Gales
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