1.
Pure Appl Chem
; 70(2): 263-6, 1998 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11542721
RESUMO
A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.
Assuntos
DNA/química , Biologia Molecular/tendências , Ácidos Nucleicos/química , Oligonucleotídeos/síntese química , Catálise , Códon , Estrutura Molecular , Ácidos Nucleicos/síntese química , Oligonucleotídeos/química , Fosfatos/química , Sulfonas/química
2.
Nucleic Acids Res
; 23(16): 3349-50, 1995 Aug 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7667115