RESUMO
A new experimental fluorescent lamp emitting UVB mainly in a narrow peak around 311 nm was compared with a conventional broad band UVB lamp in the treatment of psoriasis with the Ingram regimen. In 20 patients one arm was treated with the new lamps and the other arm with conventional lamps. In 12 patients the results were same, but the new lamp was more effective in 8 patients. In another trial, 53% of 17 patients treated with the new lamp showed good results compared with 30% of 23 patients treated with conventional lamps. In conclusion, the 311 nm UVB lamp is at least as effective as the conventional broad band UVB lamps in the treatment of psoriasis with the Ingram regimen.
Assuntos
Psoríase/radioterapia , Terapia Ultravioleta , Humanos , Dosagem RadioterapêuticaRESUMO
To investigate the mechanisms of non-immunologic contact urticaria (NICU), the effects of 1g + 1g of acetylsalicylic acid (ASA) on contact reactions to methyl nicotinate, diethyl fumarate, benzoic acid, cinnamic acid, cinnamic aldehyde and dimethyl sulfoxide were studied in 21 test subjects. Erythema and edema reactions were observed visually, and the changes in the skin blood flow were monitored using laser-Doppler flowmetry. ASA had a significant inhibitory effect on erythema from all 6 agents and also on edema from all substances except dimethyl sulfoxide. The mechanism of the effect may be a result of the inhibitory influence of ASA on prostaglandin bioformation. Thus, to avoid false negative test results, non-steroidal anti-inflammatory drugs should not be used during NICU tests.
Assuntos
Aspirina/farmacologia , Irritantes/antagonistas & inibidores , Urticária/etiologia , Acroleína/análogos & derivados , Acroleína/antagonistas & inibidores , Adulto , Benzoatos/antagonistas & inibidores , Ácido Benzoico , Cinamatos/antagonistas & inibidores , Dimetil Sulfóxido/antagonistas & inibidores , Feminino , Fumaratos/antagonistas & inibidores , Humanos , Masculino , Ácidos Nicotínicos/antagonistas & inibidores , UltrassonografiaRESUMO
Fifteen patients with chronic urticaria were treated with ultraviolet light B (UVB) for 1-3 months during the spring 1984 and a follow-up study was performed in November 1984-January 1985. Patients with cold urticaria, cholinergic urticaria and dermographism became clearly better or got rid of their symptoms more often than those with "non-specific" chronic urticaria. The good results achieved during the phototherapy held during the summer but in the autumn urticaria became worse in one third of the cases. The result suggests that UV-therapy might be worth trying in many patients with chronic urticaria.